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Magvit - instructions for use, analogs, reviews and release forms (capsules or tablets 5 mg + 350 mg) drugs for the treatment of deficiency or lack of magnesium and hypomagnesemia in adults, children and pregnancy. Composition

Magvit - instructions for use, analogs, reviews and release forms (capsules or tablets 5 mg + 350 mg) drugs for the treatment of deficiency or lack of magnesium and hypomagnesemia in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Magwith. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Magvita in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Magwith Analogues in the presence of existing structural analogs. Use to treat deficiency or lack of magnesium and hypomagnesemia in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

 

Magwith - a preparation of magnesium.Pharmacological properties of the drug are due to the pharmacological properties of magnesium and pyridoxine hydrochloride (active substances of the drug Magvit).

 

Magnesium is involved in the transport, storage and utilization of energy, the synthesis of proteins and nucleic acids in a number of mitochondrial processes; is a cofactor of many enzymatic reactions; Controls the balance of intracellular potassium. Magnesium is an obligatory participant in the synthesis of all neuropeptides in the brain. He is a member of metalloproteins 13, more than 300 enzymes, including glutationsintetazy which converts glutamate to glutamine. Magnesium is involved in the synthesis of nucleic acids and proteins in the nucleus and ribosomes, involved in the replication of deoxyribonucleic acid (DNA) transcription and ribonucleic acid (RNA). Deficiency of magnesium in the body is manifested by muscle weakness, tremors, tetany, ataxia, increased reflex excitability, irritability, sleep disorders, heart rhythm disorders, and diarrhea. With secondary magnesium deficiency, clinical symptoms are diverse and often have a nonspecific character.

 

Pyridoxine hydrochloride (vitamin B6) participates as a coenzyme in protein metabolism and synthesis of neurotransmitters, improves lipid metabolism in atherosclerosis. Entering the body, it is phosphorylated, converted to pyridoxal-5-phosphate, is part of the enzymes that perform decarboxylation and reamination of amino acids and facilitates the transport of amino acids through the cell membrane. It plays an important role in the metabolism of tryptophan, glutamic acid, cysteine, methionine. Pyridoxine is necessary for the activation of phosphorylase, for the formation of neurotransmitters, gamma-aminobutyric acid, glycine, serotonin. It is involved in the metabolism of vitamin B12, folic acid, in the synthesis of porphyrins, in the exchange of unsaturated fatty acids.

 

The use of a combined preparation containing magnesium and vitamin B6 is justified for the following reasons:

  • vitamin B6 and magnesium supplement each other's pharmacological action;
  • vitamin B6 increases the concentration of magnesium in plasma and in erythrocytes and reduces the amount of magnesium withdrawn from the body;
  • pyridoxine improves the absorption of magnesium from the gastrointestinal tract (GIT) and its penetration into cells;
  • magnesium activates the process of transformation of pyridoxine into its active metabolite pyridoxal-5-phosphate in the liver;
  • vitamin B6 helps to increase and fix intracellular magnesium.

 

Composition

 

Magnesium citrate + Pyridoxine hydrochloride + excipients.

 

Pharmacokinetics

 

The absorption of magnesium in the gastrointestinal tract is 50% of the ingested dose. In the body, magnesium is distributed mainly in the intracellular space (about 99%). The main way to excrete magnesium is the urinary system. Excretion obeys the circadian rhythm with preferential excretion at night and is regulated by the digestive tract, kidneys and bone tissue. Pyridoxine hydrochloride is absorbed in the small intestine, with blood flow spread to tissues and, penetrating into cells, is phosphorylated with the participation of adenosine triphosphate (ATP) and pyridoxal kinases. The decomposition of coenzymes is carried out by dephosphorylation and oxidation in tissues. The main product of catabolism is 4-pyridoxic acid, which is excreted in urine.

 

Indications

  • a fixed deficiency (deficiency) of magnesium, isolated or associated with other conditions;
  • hypomagnesemia (low magnesium content in the blood).

 

Forms of release

 

Capsules 5 mg + 350 mg (sometimes mistakenly called pills).

 

Instructions for use and dosing regimen

 

Before taking the drug, Magwitt should consult a doctor.

 

Adults usually prescribe inside 2 capsules 2-3 times a day. The duration of the course of treatment is 1-2 months. Capsules are taken with food, washed down with a glass of water. Treatment should be discontinued after the normalization of the magnesium concentration in the blood.

 

Side effect

  • allergic reactions to the components of the drug;
  • diarrhea, constipation;
  • nausea, vomiting;
  • stomach ache;
  • flatulence (bloating).

 

Contraindications

  • hypersensitivity to the components of the drug;
  • marked renal failure (creatinine clearance less than 30 ml per minute);
  • phenylketonuria;
  • childhood.

 

Application in pregnancy and lactation

 

During pregnancy, the drug Magwit can be used only on the advice of a doctor. Magnesium penetrates into breast milk. Avoid the use of the drug during breastfeeding.

 

Use in children

 

Magvit is contraindicated in childhood.

 

special instructions

 

In case of concomitant calcium deficiency, magnesium deficiency should be eliminated before the introduction of additional calcium intake.

 

With frequent use of laxatives, alcohol, increased physical and mental stress, the need for magnesium increases, which can lead to the development of magnesium deficiency in the body.

 

With caution apply Magvit in patients with moderate renal failure, as there is a risk of hypermagnesemia.

 

Drug Interactions

 

When using other medicines, you should always inform the doctor about this, or consult a doctor or pharmacist about the possibility of using Magvit.

 

Simultaneous use of drugs containing phosphates or calcium salts can significantly reduce the absorption of magnesium in the gastrointestinal tract. Magnesium preparations reduce the absorption of tetracycline, it is recommended to make an interval of 3 hours before using Magvit.

 

Magnesium weakens the effect of oral thrombolytic agents, worsens the absorption of iron.

 

Analogues of the drug Magwit

 

Structural analogs for the active substance:

  • Magnelis B6 forte;
  • Magne B6 forte.

 

Analogues of the drug Magvit by the pharmacological group (macro- and microelements in combinations):

  • Additive Multivitamins with minerals;
  • Actyferrin;
  • Asparks;
  • Biofer;
  • Wang-e-Day 55 plus;
  • Wi-Mineral;
  • Wi-Fi;
  • Vitaspectrum;
  • Vitrum;
  • Hematogen;
  • Gino-Tardiferon;
  • Glutamavit;
  • Jungle with minerals;
  • Dr. Theiss Multivitamol;
  • Duovit;
  • Potassium and magnesium asparaginate;
  • Calcemin;
  • Kaltsinov;
  • Complivit;
  • Lavita;
  • Magne B6;
  • Magne B6 fort;
  • Magnelis B6;
  • Magnelis B6 forte;
  • Magnesium plus B6;
  • Magnistad;
  • Maxamin forte;
  • Maltofer Foul;
  • Materna;
  • Mega Vita;
  • Megadin Pronatal;
  • Menopace;
  • Multi Sanostol;
  • Multitabs Active;
  • Multimax;
  • Multiproduct;
  • Oligovit;
  • Osteoka;
  • Pamaton;
  • Panangin;
  • Pedivit forte;
  • Pikovit D;
  • Polivit;
  • Pregnavit;
  • Pregnacea;
  • Sideral;
  • Sorbifer Durules;
  • Supradin;
  • Taxophytus;
  • Taufon Tubs Lutein;
  • Teravit;
  • Totem;
  • Three Vee Plus;
  • Fenyuls;
  • Ferretab;
  • Ferro Folgamma;
  • Ferroplex;
  • Centrum;
  • Unicab.

 

Response of a therapist

 

Magnesium deficiency in the body can occur both in isolation and in the background of certain diseases and conditions. When patients with low levels of magnesium in their blood (hypomagnesemia) are diagnosed, I often prescribe Magvit for them.My opinion about this medicine is this: a good, effective and affordable remedy. With an insignificant magnesium deficiency, one month course of therapy is usually enough to restore normal concentration in the blood. In more severe cases, magnesium deficiency takes an average of 2 months of treatment. Adverse reactions develop rarely, and therefore to cancel the reception of Magvite, too, is rare. Usually patients are well tolerated by this medication.

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