Pipem - instructions for use, analogs, testimonials and release forms (capsules or tablets 200 mg) of the drug for the treatment of pyelonephritis, cystitis, urethritis and prostatitis in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Pipem. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Pipema in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Pipem in the presence of existing structural analogs. Use for the treatment of pyelonephritis, cystitis, urethritis and prostatitis in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Pipem - uroantiseptic, a derivative of 4-quinolone.Has a bactericidal effect due to the binding of ferrous ions and inhibition of the enzyme systems of the microbial cell.

It is active against most Gram-negative bacteria: Pseudomonas aeruginosa, Escherichia coli (E. coli), Proteus spp. (Proteus), Klebsiella spp. (Klebsiella), Shigella spp. (Shigella), Salmonella spp. (salmonella).

It is also active against certain gram-positive bacteria, in particular Staphylococcus aureus (staphylococcus).

Composition

Pipemidic acid + auxiliary substances.

Pharmacokinetics

Pipem is rapidly absorbed in the gastrointestinal tract (GIT), its bioavailability is 30-50%. The maximum concentration in the blood is reached after 70-80 minutes after ingestion at a dose of 400 mg. High concentrations are created in the kidneys and the prostate gland. Passes through the fetoplacental barrier and penetrates into breast milk in trace amounts. It is excreted mostly by the kidneys in unchanged form (50-85%).

Indications

• acute and chronic urinary tract infections caused by microorganisms sensitive to the drug, including urethritis (inflammation of the urethra), cystitis (inflammation of the bladder), pyelonephritis (inflammation of the kidneys), prostatitis (inflammation of the prostate gland);
• prevention of infections with instrumental interventions on the organs of the genitourinary system (catheterization, endoscopy and others).

Forms of release

Capsules 200 mg (sometimes mistakenly called pills).

Instructions for use and dosing regimen

Pipem is taken orally, before eating. The average dose for adults is 400 mg twice a day (morning and evening), in the presence of resistant microorganisms, the dose is doubled. With staphylococcal infections, the interval between doses should not exceed 8 hours. The course of treatment - 10 days (if necessary, prolonged by a doctor). With kidney diseases - 3-6 weeks, with prostatitis - 6-8 weeks. With frequent acute infections of the urinary tract in women, concomitant with oral treatment are administered intravaginally.

Side effect

• headache, dizziness;
• impaired vision;
• weakness;
• depressive disorders;
• hallucinations;
• psychosis;
• large convulsive seizures;
• hemolytic anemia (in patients with deficiency of glucose-6-dihydrogenase);
• nausea, vomiting;
• diarrhea;
• muscle weakness;
• Myalgia (pain in the muscle);
• photosensitivity (increased sensitivity of the body, more often the skin and mucous membranes, to the action of ultraviolet radiation);
• erythema (severe reddening of the skin caused by the expansion of capillaries);
• rash, hives;
• itching.

Contraindications

• severe renal dysfunction (creatinine clearance less than 10 ml per minute);
• severe liver dysfunction;
• 1 and 3 trimesters of pregnancy;
• childhood;
• hypersensitivity to pipemidic acid.

Application in pregnancy and lactation

Pipem is contraindicated in 1 and 3 trimesters of pregnancy. Use in the 2 trimester of pregnancy and lactation (breastfeeding) should be done with caution, only in cases where the expected therapeutic effect for the mother exceeds the potential risk of side effects in the fetus or child.

Use in children

Pipem is contraindicated in childhood.

Application in elderly patients

With caution should appoint Pipem to patients older than 70 years.

special instructions

When developing allergic reactions should stop taking Pipem.

During long-term therapy, it is necessary to monitor the state of peripheral blood, liver and / or kidney function, and to conduct repeated antibioticograms.

Pipem with caution is prescribed for patients with cerebral circulation, including history, cerebral vasospasm, convulsions, epilepsy, impaired renal function.

Patients with epilepsy Pipem should be prescribed, strictly following the indications and with the observance of precautionary measures.

It is not recommended to prescribe in severe oliguria and anuria, as well as in pediatric practice because of the possible increase in muscle tone, including in newborns, and the adsorption of pipemidic acid in the cartilage tissue during development.

In the process of treatment, Pipem should increase the amount of fluid consumed (under the control of diuresis) and avoid ultraviolet irradiation due to the high risk of photosensitization.

Drug Interactions

Pipem inhibits cytochrome P450, inhibits metabolism and increases the likelihood of side effects of theophylline and caffeine.

With simultaneous use with drugs that alkalinize urine, the activity of pipemidic acid is enhanced.

Analogues of the drug Pipem

Structural analogs for the active substance:

• Palin;
• Pipegan;
• Pipelin;
• Pipemidic acid;
• Uropimide;
• Urotraktin.

Analogues of Pipem on the pharmacological group (quinolones / fluoroquinolones):

• Abaktal;
• Avelox;
• Aquamox;
• Basijen;
• Betaciprol;
• Vigamox;
• Gatispan;
• Gatifloxacin;
• Glaoufos;
• Dancyl;
• Zanotsin;
• Zarquin;
• Zimar;
• Ivacin;
• Isfipro;
• Quintor;
• Quipro;
• Xenacvin;
• Lebel;
• Levostar;
• Levofloxacin;
• Liprokhin;
• Lomacin;
• Matlevo;
• Maxiflox;
• Mossimak;
• Moflaxia;
• Nevigramon;
• The Negroes;
• Normax;
• Norfloxacin;
• Okatsin;
• Oflo;
• Oftakwix;
• Oftotsipro;
• Palin;
• Pipegan;
• Remedy;
• Renor;
• Signictsef;
• Siflox;
• Tavanik;
• Taricin;
• Ultramox;
• Uniflox;
• Uropimide;
• Factual;
• Flexine;
• Hayleflex;
• Ceprova;
• Ciloxane;
• Ciprobide;
• Ciproxyl;
• Cipromed;
• Cipropane;
• Ciprofloxacin;
• Cytar;
• Cifloxinal;
• Tsifran;
• Cyphrazide;
• Chibroxin;
• Ecology;
• Eleflox;
• Enoksor;
• Unikpef;
• Utibid.

Feedback from a urologist

I work in a hospital where patients with problems from the organs of the urinary system are examined and treated. With the preventive purpose, I prescribe the drug Pipem to the patient, who are going to have any instrumental research. This significantly reduces the incidence of infections after such interventions.With the therapeutic purpose I use Pipem in the complex treatment of patients with acute pyelonephritis, acute cystitis. The drug has always shown good results. And thus the frequency of development of by-effects is very small. Sometimes patients complain of weakness, nausea, diarrhea, which occur immediately after the end of the course of treatment.

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