Carboxim - instructions for use, analogs, reviews and release forms (injections in ampoules for injections of 150 mg) of a drug for the treatment of organophosphorous poisoning in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Carboxym. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Carboxime in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues Carboxime in the presence of existing structural analogs.Use to treat poisonings with insecticides and other organophosphorus compounds in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Carboxyme - belongs to the group of cholinesterase reactivators of the pyridinium series. It has a pronounced antidote effect in the treatment of lesions with organophosphorus compounds (OPC). Timely application of carboxyme significantly accelerates the recovery of cholinesterase activity, inhibited by FOS. It also has a positive effect on some other manifestations of poisoning (reduces bronchospasm, motor disorders, etc.). Carboxyme has low toxicity, almost no cholinolytic action.

Composition

Carboxyme + auxiliary substances.

Indications

• appearance of initial signs of poisoning FOS (agitation, miosis - narrowing of the pupil, salivation and others) in the provision of medical care, starting with the health center;
• Detection in persons under observation after being in the focus of infection, decreased activity of cholinesterase.

Forms of release

Injections in ampoules for injection 150 mg.

Instructions for use and dosing regimen

Intramuscularly 1 ml. The total dose of carboxymethylate used in the provision of care depends on the severity of the lesion.

For lesions of WCF of mild degree (anxiety, miosis, drooling, sweating) after administration of preparations of holinolitic type of action, carboxyme is used in one therapeutic dose. In some cases, repeated administration of the drug in the same dose is possible.

For lesions of FOS of moderate severity (exacerbation, myofibrillation, bronchospasm, cyanosis, tachycardia, less often bradycardia), as a rule, two applications of carboxime in one treatment dose with an interval of 2-3 hours will be required.

For lesions of WCF of severe degree (convulsions, coma, respiratory and cardiovascular insufficiency), the dose of carboxyme can be increased to 3-4 ml. This dose is given by 1 ml of the drug at intervals of 1-2 hours.

Side effect

In the recommended dose, carboxymethylsulfate does not cause side effects. However, when using large doses of carboxymethy, the following can be noted:

• deterioration of well-being;
• muscle weakness;
• dizziness;
• headache;
• nausea;
• tachycardia;
• transient paresthesia (tingling, numbness, crawling), mainly in the face;
• the phenomenon of intracardiac conduction disturbance and an increase in the systolic index.

Contraindications

If there are symptoms of intoxication, OPC contraindications for the use of carboxymethacid.

Application in pregnancy and lactation

Not described.

Use in children

Not described.

special instructions

Carboxyme is used against the background of antidote (atropine, Athens, P-10M) and other agents used in the treatment of poisonings of OP. After the introduction of a therapeutic antidote, carboxymose is administered after 1-2 hours.

Treatment of affected OPC with the use of carboxyme in all cases is carried out with a systematic control of cholinesterase activity.

Drug Interactions

Significant drug interaction in treatment with other drugs is not described.

Analogues of the drug Carboxim

The preparation has no structural analogs for the active substance.

Analogues for the pharmacological group (detoxifying agents, including antidotes):

• Anexam;
• Antakson;
• Artamine;
• Acisol;
• Bianodine;
• Brydan;
• Gepa Merz;
• Dalizol;
• Desferal;
• Digitalis;
• Ionostigmine;
• Calcium phosphinate;
• Carbactin;
• Carbopect;
• Carbosorb;
• Cardiosan;
• Kuprenil;
• Lamisplat;
• Larnamine;
• Levulose;
• Leucovorin;
• Lignin;
• Medetopect;
• Mesna;
• The mukonist;
• Naloxone;
• Naltrexone;
• Natriopholin;
• Ornilatex;
• Ornithine;
• Ornitsetil;
• Pelixim;
• Pentacin;
• Povidone;
• Polyplasdone;
• Polyphane;
• Polyphepan;
• Reamberin;
• Sanfinate;
• Sorbeks;
• Trekresan
• Ultra-Absorbant;
• Uni thiol;
• Uromitexan;
• Ferrocin;
• Filter;
• Fosrenol;
• Ceruloplasmin;
• Cystamine;
• Eksidzhad;
• Extranil;
• Entereroz;
• Epilapton.

Response of a toxicologist

Carboxyme is an effective tool used to alleviate the state of patients with intoxication after poisoning with organophosphorus compounds. Often it is necessary to use the drug for patients who have been poisoned with insecticide pairs - the drugs used to control harmful insects on personal plots, in homes and apartments. Carboxyme effectively reduces feelings of anxiety, drooling, sweating, bronchial spasm, eliminates motor disorders and other manifestations of intoxication, significantly easing the patient's condition.

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