Mildronate - instructions for use, reviews, analogs and forms of release (capsules or tablets 250 mg and 500 mg, injections in injections, syrup) of a medicament for the treatment of heart attacks and strokes in adults, children and in pregnancy
In this article, you can read the instructions for using the drug Mildronate. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Mildronate in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Mildronate in the presence of existing structural analogues.Use to treat heart attacks and strokes and improve metabolism in tissues in adults, children, as well as in pregnancy and lactation.
Mildronate - a drug that improves metabolism. Meldonium (the active ingredient of Mildronate) is a structural analogue of gamma-butyrobetaine, a substance that is found in every cell of the human body.
In conditions of increased stress, Mildronate restores the balance between delivery and the need for cells in oxygen, eliminates the accumulation of toxic metabolic products in cells, protecting them from damage; has also a tonic effect. As a result of its use, the body acquires the ability to withstand the load and quickly restore energy reserves. Due to these properties, Mildronate is used to treat various disorders of the cardiovascular system, blood supply to the brain, and increase physical and mental performance.
As a result of a decrease in the concentration of carnitine, gamma-butyrobetaine, which has vasodilating properties, is synthesized intensively.In acute ischemic injury of the myocardium, Mildronate slows the formation of the necrotic zone, shortens the rehabilitation period.
With heart failure, the drug increases myocardial contractility, increases exercise tolerance, reduces the incidence of angina attacks.
In acute and chronic ischemic disorders of cerebral circulation improves blood circulation in the ischemic focus, promotes redistribution of blood in favor of the ischemic site.
Effective in vascular and dystrophic pathology of the fundus.
The drug eliminates functional disorders of the nervous system, developing against a background of long-term alcohol intake in patients with chronic alcoholism with withdrawal syndrome.
Pharmacokinetics
After ingestion, the drug is rapidly absorbed from the digestive tract. Metabolized in the body with the formation of two major metabolites, which are excreted by the kidneys.
Indications
- in the complex therapy of IHD (angina pectoris, myocardial infarction), chronic heart failure, dyshormonal cardiomyopathy;
- in the complex therapy of acute and chronic disorders of the brainblood circulation (strokes and cerebrovascular insufficiency);
- reduced working capacity;
- physical overexertion (including athletes);
- Abstinence syndrome with chronic alcoholism (in combination with specific therapy of alcoholism);
- hemophthalmus, hemorrhages in the retina of various etiologies;
- thrombosis of the central vein of the retina and its branches;
- retinopathy of various etiologies (diabetic, hypertonic).
Forms of release
Capsules 250 mg and 500 mg (sometimes mistakenly called tablets, but the tablet form of Mildronate does not exist)
Solution for intravenous, intramuscular and parabulbar injections (injections in ampoules).
Syrup.
Instructions for use and dosing regimen
Capsules
In connection with the possibility of developing an exciting effect, the drug is recommended for use in the first half of the day.
In cardiovascular diseases, as part of a complex therapy, the drug is administered orally at a dose of 0.5-1 g per day, the frequency of application is 1-2. The course of treatment is 4-6 weeks.
With cardialgia against the background of dyshormonal dystrophy of the myocardium, Mildronate is administered orally 250 mg twice a day. The course of treatment is 12 days.
When cerebral circulation is disturbed in the acute phase, the drug is administered intravenously (in a suitable dosage form - 500 mg once a day for 10 days), then they switch to taking the drug inside 0.5-1 g per day. The general course of therapy is 4-6 weeks.
With chronic disorders of cerebral circulation, the drug is taken orally 0.5-1 g per day. The general course of therapy is 4-6 weeks. Repeated courses are prescribed individually 2-3 times a year.
With mental and physical exertion appoint inside 250 mg 4 times a day. The course of treatment is 10-14 days. If necessary, the therapy is repeated after 2-3 weeks.
Athletes are recommended to use 0.5-1 g 2 times a day before training. The duration of the course in the preparatory period is 14-21 days, during the competition - 10-14 days.
In chronic alcoholism, the drug is administered orally 500 mg 4 times a day. The course of treatment is 7-10 days.
Ampoules
In cardiovascular diseases, as part of complex therapy, the drug is prescribed in a dose of 0.5-1 g per day intravenously (5-10 ml of injection for 500 mg / 5 ml), 1-2 times a day. The course of treatment is 4-6 weeks.
When cerebral circulation is disturbed in the acute phase, the drug is administered iv every 500 mg once a day for 10 days,then switch to taking the drug inside (in a suitable dosage form - 0.5-1 g per day). The general course of therapy is 4-6 weeks.
In vascular pathology and dystrophic retinal diseases, Mildronate is injected parabulbar by 0.5 ml of an injection solution with a concentration of 500 mg / 5 ml for 10 days.
With mental and physical exertion appoint IV in 500 mg once a day. The course of treatment is 10-14 days. If necessary, the therapy is repeated after 2-3 weeks.
In chronic alcoholism, the drug is administered IV for 500 mg twice a day. The course of treatment is 7-10 days.
Side effect
- tachycardia;
- changes in blood pressure;
- psychomotor agitation;
- headache;
- dyspeptic symptoms;
- allergic reactions (redness of the skin, rashes or rashes, itching, swelling);
- general weakness;
- edema.
Contraindications
- increased intracranial pressure (including with violation of venous outflow, intracranial tumors);
- children and adolescents under 18;
- hypersensitivity to the drug.
Application in pregnancy and lactation
The safety of Mildronate in pregnancy is not proven. To avoid possible adverse effects on the fetus, the drug should not be administered during pregnancy.
It is not known whether the drug is excreted in breast milk. If you need to use Mildronate during lactation, breastfeeding should be discontinued.
special instructions
Patients with chronic liver and kidney disease should be careful with prolonged use of the drug. If you need a long (more than a month) use of the drug should consult with a specialist.
Many years of experience in the treatment of acute myocardial infarction and unstable angina in cardiac units shows that Mildronate is not a first-line drug in acute coronary syndrome.
Use in Pediatrics
In children and adolescents under the age of 18 years, the effectiveness and safety of Mildronate in the form of capsules and solution for injection is not established.
Impact on the ability to drive vehicles and manage mechanisms
Data on the adverse effect of Mildronate on the rate of psychomotor reaction is not available.
Drug Interactions
When combined, Mildronate enhances the effect of antianginal drugs, certain antihypertensive drugs, cardiac glycosides.
Mildronate can be combined with antianginal drugs, anticoagulants and antiaggregants, antiarrhythmics, diuretics, bronchodilators.
When combined with Mildronate, nitroglycerin, nifedipine, alpha-adrenoblockers, antihypertensive drugs and peripheral vasodilators may develop moderate tachycardia, arterial hypotension (caution should be exercised when using this combination).
Analogues of the drug Mildronate
Structural analogs for the active substance:
- 3- (2,2,2-Trimethylhydrazinium) propionate dihydrate;
- Vazomag;
- Idrinol;
- Cardion;
- Medatern;
- Meldonius;
- Meldonius-Eskom;
- Meldonium dihydrate;
- Melfor;
- Midolat;
- Trimethylhydrazinium propionate dihydrate.
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