Mizo - instructions for use, analogs, reviews and release forms (drops for ingestion of 60 mg in 1 ml) drugs for the treatment of chronic alcoholism in adults, children and pregnancy. Composition and alcohol

In this article, you can read the instructions for using the drug Mizo. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Mizo in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Mizo in the presence of existing structural analogs. Use for the treatment of chronic alcoholism in adults, children, as well as during pregnancy and lactation.Composition and interaction of the drug with alcohol.

Mizo - drug with anti-alcohol effect. Cyanamide (an active ingredient in the Mizo drug) inhibits acetaldehyde dehydrogenase and blocks the oxidation of alcohol to carbon dioxide and water. Increases sensitivity to alcohol, but reduces incentive motivation for its use. Accumulation of acetaldehyde (after drinking alcohol) causes nausea, vomiting, redness of the face, sensation of noise in the head and heat in the upper part of the trunk, chest tightness, difficulty breathing, palpitation, fear, convulsions, chills, etc. Re-drinking alcohol on the background of Mizo contributes the development of a negative conditioned reflex to the taste and smell of alcoholic beverages.

Composition

Cyanamide + auxiliary substances.

Pharmacokinetics

The sensitizing effect of cyanamide on alcohol appears earlier (about 45-60 minutes) and lasts shorter (about 12 hours) than the action of disulfiram. Also, unlike disulfiram, cyanamide does not give an antihypertensive effect. In addition, cyanamide has a greater specificity of action: unlike Disulfiram it blocks only acetaldehyde dehydrogenase and does not affect other enzymes,in particular to dopamine-beta-hydroxylase.

Indications

• chronic alcoholism (treatment and prevention of relapses).

Forms of release

Drops for ingestion of 60 mg in 1 ml, 4 bottles of a dropper for 15 ml.

Instructions for use and dosing regimen

The drug Mizo is prescribed internally for 12-25 drops (36-75 mg cyanamide) 2 times a day with an interval of 12 hours according to the individual scheme.

Side effect

• increased fatigue;
• drowsiness;
• skin rashes;
• noise in ears;
• transient leukocytosis;
• with simultaneous administration with ethanol (alcohol): skin hyperemia, pulsation in the head and neck, nausea, tachycardia, difficulty breathing, weakness, blurred vision, profuse sweating, chest pain; in more severe cases, vomiting, lowering blood pressure (BP), suppressing the respiratory center, collapse (the nature and severity of the symptoms depend on the amount of ethanol taken and the dose of the drug).

Contraindications

• increased individual sensitivity;
• severe heart disease;
• diseases of the respiratory tract and kidneys (with reduced function);
• severe liver disease;
• pregnancy;
• the period of breastfeeding.

Application in pregnancy and lactation

The use of Mizo during pregnancy and during breastfeeding is contraindicated.

Use in children

In pediatric practice, Mizo is not used.

special instructions

Treatment of Mizo is appointed after careful examination of the patient and warning him of the possible consequences and complications. For successful treatment, it is absolutely necessary that the patient has adequate motivation.

Treatment should be started no earlier than 12 hours after the last intake of alcohol.

With caution appoint Mizo to patients with hyperthyroidism, diabetes, epilepsy, cardiovascular disease, kidney disease. With prolonged admission should be at least 1 time in six months to monitor the function of the thyroid gland.

Cyanamide is not heat-stable and is destroyed by hot food.

Impact on the ability to drive vehicles and manage mechanisms

During the treatment of Mizo patients should refrain from driving vehicles and occupations that require an increased concentration of attention and speed of psychomotor reactions.

Drug Interactions

Alcohol contributes to the development of reactions caused by the blockade drug Mizo acetaldehyde dehydrogenase.

The effect is enhanced by inhibitors of acetaldehyde dehydrogenase (metronidazole, isoniazid, phenytoin, etc.), so co-administration with them should be avoided.

It is not recommended to prescribe simultaneously with disulfiram or before 10 days after its cancellation.

Mizo is not compatible with preparations of the aldehyde group (paraldehyde and chloral products).

Analogues of Mizo drug

Structural analogs for the active substance:

• Colme.

Analogues of Mizo drug on the pharmacological group (means for correcting disorders in alcoholism, toxic and drug addiction):

• 2-ethyl-6-methyl-3-hydroxypyridine succinate;
• Akofil;
• Antabus;
• Anti-E;
• Anti-wolf;
• Astrox;
• Biotredin;
• Butyroxane;
• Vivitrol;
• Deltaran;
• Disulfiram;
• Colme;
• Lidevin;
• Limonar;
• Mexidol;
• Mexiprim;
• Mexicin;
• Metadoxyl;
• Metostabil;
• Naltrexone FV;
• Niquitine;
• Nicomel;
• Nicoretta;
• Nicotine USP;
• Nicotinell;
• Orvagil;
• Peptide delta sleep;
• Protexoxone;
• Proproten 100;
• Selincro;
• Sulfalong;
• Teturam;
• Cytisine;
• Champix;
• Esperal;
• Ethyl methylhydroxypyridine succinate.

Recall of a narcologist

The effectiveness of Mizo drug depends largely on the mood of the patient, on his desire to get rid of alcohol dependence. If a person has made a final, firm decision, then he and drops may not be required. Of course, he begins to accept Mizo, but quickly refuses to, so to speak, drug support, because the motivation is clear in his head. And if the patient, having come to the reception, disingenuous and hopes only for magical drops, then the effect is, as a rule, zero. Many of these patients continue to drink alcohol, knowing about the possible consequences.

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