Arthrotek - instructions for use, reviews, analogs and formulations (tablets 50 mg / 200 μg and 75 mg / 200 μg) of the drug for the treatment of rheumatoid arthritis, arthrosis, headache, dental and other pain in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Arthrotek. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Artroteka in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of the Artrotheque in the presence of existing structural analogues. Use for the treatment of rheumatoid arthritis, arthrosis, headache, dental and other pain in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Arthrotek combined preparation. Diclofenac (the first active substance of the drug Arthrotek) is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties. The mechanism of action of diclofenac is related to its ability to selectively inhibit cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes.

Misoprostol (the second active substance of the preparation Arthrotek) is a synthetic analogue of prostaglandin E1, which enhances the effect of factors involved in the protection of the mucous membrane of the stomach and duodenum. Misoprostol supports the blood supply to the gastric mucosa, reduces the secretion of pepsin and hydrochloric acid in the stomach, promotes the formation of bicarbonates in the duodenum.

Composition

Diclofenac + Misoprostol + excipients.

Pharmacokinetics

The pharmacokinetics of diclofenac and misoprostol in combination are similar to the pharmacokinetics of these products when administered as separate tablets. Misoprostol is rapidly absorbed and metabolized to the active metabolite - misoprostol acid, the latter has a decay period of about 30 minutes.70% of the administered dose of misoprostol is excreted in the urine as inactive metabolites. Diclofenac sodium is also rapidly and almost completely absorbed, reversibly binds to plasma proteins; from 40 to 60% is excreted in the urine, the rest - with bile and feces. Pharmacokinetic interaction between these two substances is not observed. After repeated administration of Arthrochet, no cumulation of diclofenac, misoprostol or misoprostol acid occurs.

Indications

• rheumatoid arthritis;
• osteoarthritis (arthrosis);
• ankylosing spondylitis;
• arthritis of various etiologies;
• arthralgia (pain in the joints);
• myalgia (pain in the muscles);
• postoperative and post-traumatic pain;
• algodismenorea (painful menstruation);
• toothache;
• headache.

Forms of release

Tablets coated with 50 mg / 200 μg and 75 mg / 200 μg.

Instructions for use and dosing regimen

The drug is taken orally while eating, without chewing; tablets can not be broken or dissolved.

Arthrotheca is recommended for use in the following doses: tablets containing a dose of 50 mg / 200 mcg - 1 tablet 2-3 times a day; tablets containing a dose of 75 mg / 200 mcg - 1 tablet 2 times a day.

Side effect

• stomach ache;
• nausea, dyspepsia;
• flatulence (bloating);
• diarrhea;
• reduction of platelet aggregation, prolongation of bleeding time;
• fluid retention and edema (especially in predisposed patients);
• menorrhagia (prolonged, longer than 7 days, and abundant, over 100 ml, menstruation with the continuity of the menstrual cycle) and metrorrhagia (the appearance of uterine bleeding in the intermenstrual period) in women at pre- and post-menopausal age;
• headache, dizziness;
• skin rash.

Contraindications

• hypersensitivity to the components of the drug;
• bleeding (including gastrointestinal).

Application in pregnancy and lactation

Contraindicated in the use of Artrothe during pregnancy and lactation (breastfeeding). Women of childbearing age should not be treated with Artrothek until pregnancy is excluded; they also need to use reliable contraceptive measures throughout the therapy period. If pregnancy is expected, then this drug should be canceled.

Use in children

Data on the safety and efficacy of Arthrochet in children under the age of 18 years are absent.

Application in elderly patients

Use with caution in elderly patients. In patients aged 65 years and older, the profile of adverse reactions of diclofenac / misoprostol is similar to that in younger patients with a single clinically significant difference in that patients 65 years of age or older are more likely to have adverse effects of the Artrochet on the gastrointestinal tract (GI tract).

special instructions

Arthrothec with caution is prescribed for patients with congestive heart failure, impaired renal function, predisposition to fluid retention in the body.

Impact on the ability to drive vehicles and manage mechanisms

During the period of treatment with Artrothek, the speed of psychomotor reactions may decrease.

Drug Interactions

Diclofenac is displaced by Acetylsalicylic acid from the sites of its binding to albumins, which leads to a decrease in the concentration of diclofenac in plasma, and also to a decrease in its maximum concentration in plasma. In this regard, the simultaneous use of arthrochet and acetylsalicylic acid is not recommended.

In patients who received both Digoxin and diclofenac, an increased level of digoxin was recorded.Therefore, patients receiving both digoxin and Arthrotek should be under medical supervision to detect the toxic effect of digoxin.

Since simultaneous use of Arthrochet with potassium-sparing diuretics may increase potassium levels in serum, in such cases it is necessary to monitor the level of this indicator.

With the simultaneous administration of an arthrothe with angiotensin-converting enzyme (ACE) inhibitors, renal function may worsen.

Arthrochet should be administered with caution to patients receiving insulin.

Caution should be exercised when concomitantly with NSAIDs, including Arthrochet, methotrexate, because NSAIDs may increase plasma Methotrexate levels.

Diclofenac reduces renal clearance of lithium and increases the concentration of lithium in plasma. Therefore, patients receiving lithium, Arthrochet should be administered with caution.

Antacids can slow the absorption of diclofenac. Magnesium-containing antacids can provoke an exacerbation of diarrhea associated with misoprostol.

Analogues of Arthrotek

There are no structural analogs to the active substance of the drug Arthrotek.

Analogues for the pharmacological group (NSAIDs - derivatives of acetic acid and related compounds in combinations):

• Diklogen;
• Dicloran plus;
• Dolaren;
• Indovazin;
• Neurodiclavitis;
• Panoxen;
• Trixymethacin.

Analogues on the curative effect (means for relief of pain in the joint):

• Actasulide;
• Ambien;
• Amelotex;
• Antigrippin;
• Apizarthron;
• Arkoxy;
• Arthrosan;
• Ascofen;
• Aspirin;
• Aflubin;
• Aertal;
• Brustan;
• Brufen;
• Viprosal;
• Voltaren;
• Voltaren Emulgel;
• Diklobene;
• Diqlovit;
• Diclofenac;
• Dimexide;
• Dolgit;
• Ibuklin;
• Ibufen;
• Capsicam;
• Caffetin;
• Ketanov;
• Ketonal Duo;
• Ketoprofen;
• Ketorolac;
• Ketorol;
• Meloksikam;
• Menovazine;
• Migrenol;
• Movix;
• Naisylate;
• Nyz;
• Next;
• Nimesil;
• Niflugel;
• Novigan;
• Paracetamol;
• Pentalgin;
• Pliwalgin;
• Prohodol;
• Spasgan;
• Spazmalgon;
• Tempalgin;
• Teraflex Advance;
• Fendivia;
• Finalgon;
• Flamadex;
• Flamax;
• Flamax forte;
• Fleksen;
• Hyrumat;
• Celebrex;
• Yunispaz.

Response of a rheumatologist

Arthrotek tablets I use in the complex treatment of rheumatoid arthritis, arthritis of another origin, arthrosis. The main purpose of this drug is the relief of joint pain.And, according to the patients, the medicine really removes pain very well. But at the same time, almost all of them complain that almost from the first day of treatment there are disorders of the gastrointestinal tract, expressed to a greater or lesser extent. Most often it is diarrhea, less often - bloating. It is for this reason that I assign Artrotek not as often as it could be done.

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