Treksil - instructions for use, reviews, analogs and form of release (tablets 60 mg) of the drug for the treatment of allergic rhinitis, bronchial asthma and eczema in adults, children and pregnancy. Composition and alcohol

In this article, you can read the instructions for using the drug Trexile. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of experts on the use of Trexile in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Trexile in the presence of existing structural analogues. Use for the treatment of allergic rhinitis, bronchial asthma,neurodermatitis and eczema in adults, children, as well as during pregnancy and lactation. Composition and interaction of the drug with alcohol.

Trexile - blocker of histamine H1 receptors. Has anti-allergic effect. Does not penetrate the blood-brain barrier (BBB) ​​and does not affect the central nervous system (CNS). The effect of the drug develops 1-2 hours after admission, reaches a maximum after 3-4 hours. The duration of the action is 12 hours.

Composition

Terfenadine + excipients.

Pharmacokinetics

Well absorbed from the gastrointestinal tract (GIT); binding to plasma proteins - 97%; most of it is converted into active metabolites in the liver. After oral administration (60 mg) the maximum concentration in the plasma of terfenadine is reached after 1 hour, active metabolites - after 2-3 hours. The action begins in 1-2 hours, reaches a maximum in 3-4 hours and lasts more than 12 hours. It is distributed in all tissues, accumulates in the liver and lungs. It is excreted by the intestine (60% of the administered dose) and by the kidneys (40%), mainly in the form of metabolites.

Indications

• allergic rhinitis;
• allergic conjunctivitis;
• allergic skin lesions with pruritus and erythema (redness);
• angioedema (edema of Quincke);
• allergic diseases of the digestive tract;
• in prophylactic purposes before the introduction of radiopaque substances;
• bronchial asthma (as part of complex therapy);
• atopic dermatitis (neurodermatitis, eczema);
• allergic contact dermatitis;
• simple irritant contact dermatitis;
• simple chronic lichen (limited neurodermatitis);
• coin-like eczema.

Forms of release

Tablets of 60 mg.

Instructions for use and dosing regimen

Inside adults and children over 12 years of age - 60 mg 2 times a day or 120 mg 1 time in the morning. The maximum daily intake for adults is 480 mg.

Children from 6 to 12 years - 30 mg 2 times a day. Taking into account the body weight, the maximum daily dose for children is 2 mg per 1 kg of body weight.

Side effect

• dyspeptic disorders;
• dryness of the mucous membranes of the mouth, nose, pharynx;
• cough;
• sore throat;
• epistaxis (nasal bleeding);
• increased level of transaminases;
• alopecia (baldness);
• angioedema;
• photosensitization (increasing the sensitivity of the body (often the skin and mucous membranes) to the action of ultraviolet or visible radiation;
• rash;
• extrasystole (in patients with impaired liver function).

Contraindications

• pregnancy and lactation (breastfeeding);
• hypersensitivity to terfenadine.

Application in pregnancy and lactation

Trexile is contraindicated in pregnancy and lactation.

Use in children

Use is possible in children from 6 years of age according to the dosing regimen.

special instructions

When overdosage Treksila recommended removal of non-sucking drug (gastric lavage), cardiomonitoring for at least 24 hours (may occur extrasystole), symptomatic and supportive therapy.

Impact on the ability to drive vehicles and manage mechanisms

Treksil can be used in patients whose work requires increased attention, but not for drivers of transport.

Drug Interactions

Treksil does not affect the depressive effects of ethanol (alcohol) and benzodiazepines, enhances the action of corticosteroids and sodium cromoglycate, is compatible with bronchodilators and H2 receptor antagonists.

Analogues of the drug Treksil

Structural analogs for the active substance:

• Bronal;
• Tamagon.

Analogues of the drug Treksil on the pharmacological group (antihistamines):

• Aviamarin;
• Azelastine;
• Alerza;
• Alerpriv;
• Allegra;
• Allervay;
• Allergen;
• Allergodyl;
• Allertec;
• Allergies;
• Bonin;
• Bronal;
• Visallergol;
• Vizin;
• Gismanal;
• Histaglobin;
• Gifast;
• Glencet;
• Dezal;
• Desloratadine;
• Diazoline;
• Diphenhydramine;
• Donormil;
• Dramina;
• Zirtek;
• Zodak;
• Kestin;
• Claritin;
• Clarifer;
• Clarotadine;
• Clemastine;
• Levocetirizine;
• Lomilan;
• Loratadine;
• Lordestin;
• Mebhydrogen;
• Mibyron;
• Nalorius;
• Nixar;
• Olopatallerg;
• Opatanol;
• Parliamentary;
• Peritol;
• Pipolphen;
• Primalan;
• Reactin;
• The Raslip;
• Rivtagil;
• Rupafin;
• Semprex;
• Sirep;
• Sowentol;
• Stemise;
• Suprastinex;
• Suprastin;
• Tavegil;
• Tamagon;
• Tyrror;
• Fexadine;
• The fexophagus;
• Fenistil;
• Fenkarol;
• Fenspiride;
• Chloropyramine;
• Cezer;
• Cetirizine;
• Cetrin;
• Ebastin;
• Ezlor;
• Eladon;
• Erespal;
• Erispirus;
• Erius.

Review of the allergist doctor

The effectiveness of the drug Treksil, as an antiallergic agent, is quite high. I assigned it to patients with eczema, neurodermatitis, allergic rhinitis. But the incidence of adverse reactions during treatment made me gradually give up using this drug. The most pronounced undesirable reactions were noted from the upper respiratory tract: sore throat, dryness of the oral mucous membranes, nasal cavity and pharynx, an obsessive cough.And the patients began to make similar complaints already in the first week of therapy. There are enough analogues for this medicine, so at present I do not prescribe Trexil to my patients.

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