Benzobarbital - instructions for use, reviews, analogs and formulations (tablets 50 mg and 100 mg) drugs for the treatment of epilepsy, seizures and insomnia in adults, children and pregnancy. Composition and alcohol

In this article, you can read the instructions for using the drugBenzobarbital. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of benzobarbital in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Benzobarbital analogues in the presence of existing structural analogues. Use for the treatment of epilepsy, seizures, insomnia and hyperbilirubinemia in adults, children, as well as during pregnancy and lactation. The composition of the drug and its interaction with alcohol.

Benzobarbital - a drug with anticonvulsant, hypnotic and sedative effect. Strengthens inhibitory GABA-ergic (GABA-gamma-aminobutyric acid) effects on the central nervous system (CNS), especially in the thalamus, the ascending activating reticular formation of the brainstem at the level of intercalary neurons. Reducing the permeability of nerve fiber membranes for sodium ions, reduces the spread of impulses from the focus of epileptic activity. The effect occurs 20-60 minutes after oral administration.

Composition

Benzobarbital + auxiliary substances.

Pharmacokinetics

Metabolized Benzobarbital with the formation of phenobarbital, which has antiepileptic effect. Binding to blood plasma proteins is weak. High concentrations are found in the brain, liver and kidneys. Penetrates through the histogematic barriers, excreted in breast milk. It is excreted by the kidneys both in unchanged form and in the form of metabolites.

Indications

• epilepsy of various genesis, generalized and partial seizures;
• hyperbilirubinemia;
• hemolytic disease of newborns;
• insomnia.

Forms of release

Tablets of 50 mg and 100 mg.

Instructions for use and dosing regimen

Install individually. Inside - 100 mg 3 times a day. The maximum dose: single dose - 300 mg, daily - 800 mg. Treatment begins with a single dose of a single dose. After 2-3 days, gradually increase the dose to achieve a clinical effect (reducing the frequency or complete cessation of seizures). Treatment is long.

Children aged 3-6 years - 25-50 mg per reception (100-150 mg per day), 7-10 years - 50-100 mg per reception (150-300 mg per day), 11-14 years - on 100 mg on reception (300-400 mg a day). The maximum dose for children (older age): single dose - 150 mg, daily - 450 mg.

Side effect

• drowsiness;
• lethargy, inhibition;
• headache;
• ataxia (partial or complete loss of coordination of voluntary muscle movements);
• nystagmus (involuntary vibrational movements of the eyes of high frequency);
• speech difficulties (in these cases, dose adjustment or caffeine administration is required);
• photophobia;
• thrombocytopenia, anemia;
• lowering of blood pressure (BP);
• thrombophlebitis (inflammation of the veins);
• deterioration of appetite;
• allergic reactions;
• bronchospasm (contraction of the smooth muscles of the bronchi and a decrease in their lumen);
• addiction, drug dependence;
• withdrawal syndrome;
• impaired liver and kidney function.

Contraindications

• severe impairment of kidney and / or liver function;
• chronic heart failure 2-3 stages;
• porphyria (hereditary impairment of pigmentary metabolism with increased content of porphyrins in the blood and tissues and enhanced excretion in urine and feces);
• anemia (decrease in the concentration of hemoglobin in the blood, more often with a simultaneous decrease in the number of erythrocytes or the total volume of erythrocytes);
• bronchial asthma;
• respiratory insufficiency;
• diabetes;
• adrenal insufficiency;
• hyperkinetic (pathological sudden involuntary movements in one, or a whole group of muscles, by an erroneous command of the brain);
• Depressive conditions (with suicidal attempts);
• hypersensitivity to benzobarbital.

Application in pregnancy and lactation

Do not prescribe Benzobarbital during pregnancy and breastfeeding.

Use in children

When appointing children, it is necessary to strictly follow the recommendations for dosing.

special instructions

In patients who have previously taken barbiturates, when switching to benzobarbital treatment, sleep disturbances are possible. In these cases, prescribe for the night Phenobarbital (50-100 mg) or other sleeping pills.

Impact on the ability to drive vehicles and manage mechanisms

During the treatment with benzobarbital, one should refrain from engaging in potentially dangerous activities requiring increased attention and speed of psychomotor reactions (driving vehicles or working with mechanisms).

Drug Interactions

Strengthening the effects of opioid analgesics, anesthetics, antipsychotics, anxiolytics, tricyclic antidepressants, ethanol (alcohol), hypnotic drugs.

With simultaneous use, a decrease in the effectiveness of paracetamol, anticoagulants, tetracyclines, griseofulvin, glucocorticosteroids (GCS), mineralocorticoids, cardiac glycosides, quinidine, vitamin D, xanthines is observed.

With simultaneous use with drugs that have a mielodepressivnoe effect, there is an increase in hematotoxicity.

Analogues of the drug Benzobarbital

Structural analogs for the active substance:

• Benzonal.

Analogues of the drug Benzobarbital by pharmacological group (antiepileptic drugs):

• Actinerval;
• Algerian;
• Acetazolamide;
• Benzon;
• Briviak;
• Valopixime;
• Valparin;
• Wimpat;
• Gabagamma;
• Gabapentin;
• Gapentec;
• Depakin;
• Diazepam;
• Dipromal;
• Diphenine;
• Zagreton;
• Zenicetam;
• Zeptol;
• Inovevelon;
• Carbamazepine;
• Carbapine;
• Caten;
• Keppra;
• Clonazepam;
• Convilept;
• Convulex;
• Convulsofin;
• Lameptil;
• Lamyctal;
• Lamotriks;
• Levetinol;
• Levetiracetam;
• Lethiram;
• Mazepine;
• Maliazine;
• Mysolin;
• Neuronthin;
• Paglyuferal;
• Prabiegin;
• Pregabio;
• Primidone;
• Relium;
• Rivotril;
• Ropimat;
• Sabril;
• Seizar;
• Sibazon;
• Suxilep;
• Tebantin;
• Tegretol;
• Topalepsin;
• Topamax;
• Topiramate;
• Thoreal;
• Torapimat;
• Trileptal;
• Ficomp;
• Phenobarbital;
• Finlepsin;
• Chloracon;
• Exalieff;
• Eltator;
• Enkorat;
• Epial;
• Epimax;
• Epitera;
• Epitropil.

Review of the neurologist's doctor

In the treatment of patients with epilepsy, I do not often, but I use the drug Benzobarbital. Against the background of therapy with this anticonvulsant, the frequency of epileptic seizures decreases, the patients feel better. But I note that adverse reactions during the treatment with benzobarbital develop quite often. This is drowsiness, and a marked decrease in blood pressure, and changes in blood tests. In this regard, most patients had to cancel the drug and select other antiepileptic drugs.For the treatment of insomnia drug Benzobarbital I do not use.

Similar medicines:

Other medicines: