Triesid - instructions for use, analogs, testimonials and tablet formulations of a medicinal product for the treatment of hypertension or hypertension in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Triesid. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Tiresis in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Tiresis in the presence of existing structural analogues. Use to treat primary and secondary hypertension and reduce high blood pressure in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Triesid - has antihypertensive, diuretic, vasodilating, sedative action. Reserpine (active ingredient of the drug Tiresid) causes depletion of catecholamine stores in the endings of postganglionic sympathetic fibers, depresses the central nervous system (CNS), and decreases the heart rate (HR). Dihydralazine (active ingredient of the drug Tiresid) reduces the tone of the smooth muscles of arterial vessels, causes vasodilation and thereby reduces the overall peripheral vascular resistance (OPSS), increases renal blood flow. Hydrochlorothiazide (active ingredient of the drug Tiresid) promotes the excretion of sodium, chlorine and water, a decrease in the volume of circulating blood (BCC), a decrease in cardiac output and a gradual decrease in OPSS.

Composition

Reserpine + hydrochlorothiazide + dihydralazine sulfate + potassium chloride + excipients.

Indications

• arterial hypertension (high blood pressure).

Forms of release

Tablets 0.1 mg + 10 mg + 10 mg + 350 mg.

Instructions for use and dosing regimen

Inside, after eating. Doses are set individually. Usually start with 1 tablet 1-2 times a day, then (in case of insufficient effect), the dose is increased by 1 tablet every 7-14 days.The maximum daily dose is 5 tablets, supporting - 1-2 tablets per day.

Side effect

• depression;
• headache;
• dizziness;
• impaired vision and hearing;
• drowsiness;
• nasal congestion;
• dyspnea;
• heartburn;
• diarrhea;
• dry mouth;
• arrhythmia (cardiac rhythm disturbance);
• postural hypotension (excessive reduction of blood pressure in an upright position).

Contraindications

• hypersensitivity to any of the components of the drug;
• severe renal failure (creatinine clearance less than 30 ml / min);
• aortic and mitral stenosis;
• constrictive pericarditis;
• isolated right ventricular failure due to pulmonary hypertension;
• hyperuricemia with clinical manifestations;
• pregnancy and lactation;
• children under 12 years.

Application in pregnancy and lactation

It is not recommended to use Tiresid in the last 3 months of pregnancy and during lactation.

Use in children

Triside is not prescribed for children under 12 years of age.

special instructions

Triside should be administered with extreme caution to patients with suspected coronary heart disease, sinus bradycardia, conduction disorders,heart failure, after a recent myocardial infarction, patients with cerebral and coronary atherosclerosis, with bronchial asthma, chronic obstructive pulmonary diseases.

In connection with the possibility of damage to the mucous membranes of the oral cavity, consultation of the dentist is necessary.

When signs of depression appear, the drug should be discontinued because of the risk of suicidal action. Patients who underwent myocardial infarction should not be prescribed a drug until a stabilizing period occurs. It is necessary to systematically monitor the condition of patients with impaired hepatic function due to possible direct adverse effects on the liver of dihydralazine and the possibility of electrolyte exchange disorders when hydrochlorothiazide is administered and the risk of hepatic coma development. In patients with severe renal and hepatic dysfunction, correction of doses or interval between doses is necessary to avoid the risk of cumulation.

Given the property of reserpine to increase the motor skills and secretion of the gastrointestinal tract, care should be taken when prescribing the drug to patients with peptic ulcer, erosive gastritis and cholelithiasis.Triside can exacerbate the manifestations of systemic lupus erythematosus, acute rheumatoid arthritis. It is necessary to determine in these patients the phenotype of the rate of acetylation, to conduct a test for antinuclear antibodies.

The use of the drug before surgical intervention is impossible, since during the operation there may be violations of hemodynamics, as well as possible lowering of arterial pressure, the occurrence of angina attacks, changes on the ECG, which indicates the development of ischemia and, in some cases, myocardial infarction. It is important that the anesthesiologist is aware of the preliminary administration of Tiresid.

The appointment of the drug to people with diabetes can reduce glucose tolerance, increase the concentration in the plasma of cholesterol, triglycerides and uric acid.

In elderly patients, a single dose and the interval between admission should be carefully adjusted, taking into account clinical compliance for treatment and tolerability.

Drug Interactions

The antihypertensive effect of treiside is enhanced with simultaneous use with other antihypertensive agents (beta-blockers, vasodilators, calcium antagonists).When combined with potassium-sparing diuretics and ACE inhibitors, potassium levels in the blood serum may increase.

With simultaneous reception with treeside, the depressing effect on alcohol on the central nervous system, analgesics, antihistamines and psychotropic drugs, antipsychotics, barbiturates, first-generation antihistamines, and tricyclic antidepressants.

The drug weakens the action of levodopa. Possible increased risk of developing extrasystole, bradycardia, other rhythm disturbances when combined with cardiac glycosides. The hypotensive effect of Tricrezide decreases with simultaneous use with non-steroidal anti-inflammatory drugs.

Preparations of anion-exchange resins (colestyramine, cholestinol) worsen the absorption of Tiresid since the latter may increase the sensitivity to allopurinol, while simultaneously increasing the risk of adverse reactions to amantadine and the manifestations of hyperglycemic action of the diazoxide.

Simultaneous reception of Tiresid with calcium preparations may lead to an increase in the concentration of calcium in the blood, and with cyclosporine, an increase in the risk of hyperuricemia.

If you need to take MAO inhibitors, these drugs should be canceled no later than 14 days before the start of taking Tiresid because of the possible development of hypertensive crisis.

Tricyclic antidepressants can weaken the action of Tiresid. Means for anesthesia increase the hypotensive effect of Tricrezide, so the drug must be canceled a few days before surgery.

The appointment of trireside with drugs of digitalis can lead to sinus bradycardia. With simultaneous use with lithium preparations, it is possible to increase the level of lithium in the blood, therefore, a systematic control of the lithium content in the blood is necessary, since in the event of polyuria an antidiuretic effect is possible.

Analogues of drug Tiresid

There are no structural analogs for the composition of active substances.

Analogues for the pharmacological group (diuretics in combinations):

• Adelphan;
• Arifarm;
• Azenozin;
• Brinerdin;
• Brusniver;
• Brusnilan;
• Ginjaleling;
• Diazide;
• The Zocardis;
• Cristepin;
• Lespenefril;
• Moderetik;
• Niebelong;
• Normatens;
• Sinepres;
• Teveten;
• Triazide;
• Triamthesis;
• Triam;
• Triampur;
• Triamtel;
• Triplicksam;
• Tritenzine;
• Phytolysin;
• Phytonefrol;
• Furesis;
• Tzimycycle;
• Edarby;
• Ecapress.

Response of a therapist

Triesid is an effective complex drug used to treat elevated blood pressure of various nature. Tablets well reduce pressure, soothe, show active diuretic and vasodilating effect. I prescribe the drug to patients with both primary and secondary arterial hypertension. It should be noted that a noticeable therapeutic effect of taking tablets does not appear quickly - only two to three weeks after the start of therapy. At the very beginning of treatment, in order to avoid the development of side effects, the dose prescribed by the doctor is strictly forbidden.

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