Novosept - instructions for use, reviews, analogs and forms of release (spray 25 ml, lozenges or Forte tablets) medications for the treatment of angina, stomatitis, inflammation of the gums in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Novosept. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of experts on the use of Novosept in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Novosept analogues in the presence of existing structural analogues. Use for the treatment of angina, stomatitis, inflammation of the gums in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Novosept - has a bactericidal, antifungal, and local exhalation effect due to its active components: cetylpyridinium chloride (one of the active substances of Novosept) - antiseptic from the group of quaternary ammonium compounds, refers to cationic detergents. Has a bactericidal action against a wide range of gram-positive and, to a lesser extent, gram-negative bacteria. The antimicrobial activity of cetylpyridinium chloride is due to its non-specific interaction with various components of the bacterial cell: the membrane, ribosomes, proteins and enzymes, as a result of which osmotic balance, respiration, carbohydrate and protein metabolism are violated, and all this leads to the death of the bacterium. Cetylpyridinium chloride also suppresses certain groups of viruses and fungi. Inactive against bacterial spores.

Tetracaine hydrochloride - an effective local anesthetic, quickly removes or reduces the sensation of pain.

Zinc - an oligoelement, has an immunomodulatory effect.

Composition

Tetracaine hydrochloride + cetylpyridinium chloride + zinc sulfate + excipients.

Pharmacokinetics

Cetylpyridinium chloride performs a local antimicrobial effect in the oral cavity as it dissolves. Absorbed in the gastrointestinal tract. It is distributed in the liver, lungs, kidneys. It is excreted through the kidneys and with bile mostly in unchanged form.

Tetracaine is rapidly absorbed when applied to mucous membranes. Like other local anesthetics, tetracaine is primarily concentrated in the lungs, and after 90 minutes in high concentrations it can be found in the liver, kidneys and adrenal glands. Its binding to plasma proteins is 85%.

Indications

Local treatment of inflammation of the mucous membranes of the mouth and pharynx:

• stomatitis;
• gingivitis;
• tonsillitis;
• pharyngitis.

Forms of release

Lozenges 100 μg + 1.5 mg + 13.3 mg Forte (sometimes mistakenly called lollipops or tablets).

Spray for topical application 25 ml.

Medicinal forms in the form of ointments and cream at the time of publication in the Directory did not exist.

Instructions for use and dosing regimen

Use topically.

The spray is sprayed onto the mucous membrane of the mouth and throat when breathing is delayed. For adults - 3 injections at the reception 4-6 times a day with an interval of 2 hours.The usual course of treatment is not more than five days.

The lozenges dissolve without chewing. For adults - 4-6 lozenges a day with an interval of 2 hours. The usual course of treatment is not more than five days.

Side effect

• allergic reactions (hives, itching, anaphylactic shock, impaired swallowing).

Contraindications

• hypersensitivity to the drug components, local anesthetics;
• violation of the integrity of the mucous membranes;
• acute renal or hepatic insufficiency;
• pregnancy, lactation;
• children and adolescence up to 18 years.

Application in pregnancy and lactation

Novosept and Novosept Forte are contraindicated in pregnancy and lactation.

Use in children

Contraindicated in children and adolescents under the age of 18 years.

special instructions

If the disease is accompanied by fever, headache, nausea, and if there is no improvement within five days of treatment, you should consult your doctor.

Long-term treatment (more than 5 days) can cause a disturbance of the balance of the natural microflora of the oral cavity and pharynx with the risk of developing pathogenic bacteria and fungi.

Indication for patients with diabetes mellitus - one lozenge contains 2.5 grams of sugar.

Drug Interactions

Drugs that inhibit cholinesterase (antimiasthenic, cyclophosphamide, demecarium, ecothyophate, insecticides, isoflurafate, thiotepa), reduce the metabolism of tetracaine hydrochloride and increase its toxicity. With simultaneous admission with anticoagulants (dalteparin, enoxaparin, heparin, warfarin), the risk of bleeding increases.

When used with monoamine oxidase inhibitors (furazolidone, procarbazine, selegiline), the risk of lowering blood pressure increases.

Tetracaine hydrochloride enhances and lengthens the effect of myorelaxing drugs.

Beta-adrenoblockers slow down the metabolism of tetracaine hydrochloride, increasing its toxicity (decrease in hepatic blood flow).

Zinc is incompatible with silver salts, quinine, ichthyol, citral (forms poorly soluble compounds), with alkaline-reacting substances (forms zinc oxide hydrate), with Protargol (coagulated).

Zinc reduces the absorption of tetracyclines, copper (should not be used until 2 hours after taking these medicines).

Thiazide diuretics increase the excretion of zinc in the urine.

Folic acid may impair the absorption of zinc to a small extent.

High doses of iron, penicillamine and other complexing drugs significantly reduce zinc absorption (should not be used until 2 hours after taking these medicines).

Cetylpyridinium is not compatible with anionic surfactants.

Analogues of the drug Novosept

Structural analogs for the composition of active substances:

• Novosept Forte.

Analogues for the pharmacological group (local anesthetics in combinations):

• Acrylic;
• Alfacaine;
• Amprovisol;
• Anestesol;
• Anti Angin;
• Articaine;
• Artifrin;
• Aurobin;
• Brilocaine;
• Dent;
• Dentinox;
• Drill;
• Instillagel;
• Kamistad;
• Crate;
• The leader;
• Lidochlor;
• Markain;
• Menovazine;
• Sparrow;
• Otypax;
• Otyrerelax;
• Prilocaine;
• Primacaine;
• Procto-Glivenol;
• Septanest;
• Scandinibs;
• Ubistezin;
• Ultracaine;
• Fastin;
• Folikap;
• Zertacaine;
• Cytokartin;
• Emla.

Feedback from an otolaryngologist

Novosept (including Forte form) is an effective tool for complex treatment of inflammatory pathologies of the larynx and oral cavity of various nature.I often prescribe spray and lozenges to patients with angina. One of the main active substances of the drug acts as an effective antiseptic, showing bactericidal action against many pathogenic invasive microorganisms. In addition, Novosept quickly relieves pain and facilitates swallowing with angina. And zinc, which is part of the medicine, stimulates local immunity, greatly accelerating this recovery.

Similar medicines:

Other medicines: