Complamine - instructions for use, reviews, analogs and forms of release (injections in ampoules for injections in a solution of 300 mg and 1500 mg, dragees or tablets 500 mg Retard) for the treatment of atherosclerosis and thrombosis in adults, children and pregnancy

In this article, you can read the instructions for using the drug Complymine. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Compline in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Compline with available structural analogues.Use to treat atherosclerosis, hypercholesterolemia, thrombosis and embolism in adults, children, as well as during pregnancy and lactation.

Complymine - a means that improves microcirculation. Combines the properties of theophylline and nicotinic acid. Causes the widening of peripheral vessels, improves collateral circulation, improves microcirculation, improves oxygenation and nutrition of tissues. Has antiaggregant effect, activates the processes of fibrinolysis, improves cerebral circulation, reduces the viscosity of the blood.

Enhances oxidative phosphorylation and the synthesis of adenosine triphosphate (ATP). Blocking adenosine receptors and phosphodiesterase (PDE), increases the content of cyclic adenosine monophosphate (cAMP) in the cell, substrate stimulates the synthesis of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP).

Reducing the overall peripheral vascular resistance (OPSS) and increasing myocardial contractions, contributes to an increase in the minute volume of blood and enhance cerebral circulation, reduces the severity of cerebral hypoxia.

Causes a nicotine-like syndrome, accompanied by hyperesthesia of the mucosa of the nasal cavity and mouth: exacerbates the olfactory and taste sensitivity. In this regard, the smell and taste of alcoholic beverages and dishes offered during the nicotine-like reaction is perceived more harsh and unpleasant.

With prolonged use has antiatherosclerotic effect, activates the processes of fibrinolysis, reduces the concentration of cholesterol and atherogenic lipids, increases the activity of lipoprotein lipase, reduces the viscosity of blood, reduces platelet aggregation.

Composition

Xanthinal nicotinate + auxiliary substances.

Indications

• Raynaud's disease;
• obliterating endarteritis and atherosclerosis of the vessels of the extremities;
• Buerger's disease (obliterating thromboangiitis);
• diabetic angiopathy;
• vascular thrombosis and embolism;
• disorders of cerebral circulation;
• cerebral atherosclerosis (atherosclerosis of the brain vessels);
• atherosclerosis of the coronary vessels;
• hypercholesterolemia;
• hypertriglyceridemia;
• intrauterine and postnatal fetal asphyxia;
• trophic ulcers of the lower leg;
• hard-healing wounds;
• decubitus.

Forms of release

Injections in ampoules for injection in a solution of 300 mg and 1500 mg.

Dragee 500 mg retard (sometimes mistakenly called pills).

Instructions for use and dosing regimen

Dragee Complamine retard is taken orally - 0.5-1 g 2-3 times a day after meals.

The solution is administered intramuscularly at a dose of 0.3-0.6 g 1-3 times a day. Intravenously struino, slowly, in the patient's lying position, in a dose of 0.3-0.8 g 1-3 times a day. Intravenous drip - 0,15-0,9 g in 250-500 ml of physiological solution at a speed of 30-40 drops per minute.

Side effect

• lowering of blood pressure (BP);
• a transitory sensation of heat, redness of the skin;
• weakness;
• dizziness;
• nausea;
• gastralgia (pain in the stomach);
• diarrhea;
• change in glucose tolerance;
• increase in serum levels of transaminases, alkaline phosphatase, uric acid.

Contraindications

• acute bleeding;
• acute myocardial infarction;
• mitral stenosis;
• acute heart failure;
• chronic heart failure in the stage of decompensation;
• arterial hypotension;
• peptic ulcer of the stomach and duodenum in the phase of exacerbation;
• acute renal insufficiency;
• glaucoma;
• pregnancy;
• increased sensitivity to xanthinal nicotinate.

Application in pregnancy and lactation

Complamine is contraindicated in pregnancy and lactation (breastfeeding).

Use in children

The use of the drug Complamine in childhood is not described.

special instructions

Use with caution in labile or unstable blood pressure.

With caution apply simultaneously with antihypertensive drugs.

Impact on the ability to drive vehicles and manage mechanisms

With extreme caution apply to drivers of vehicles, as well as patients involved in potentially hazardous activities.

Drug Interactions

With simultaneous use with drugs that have antihypertensive effects (beta-adrenoblockers, ergot alkaloids, alpha-adrenoblockers, sympatholytic drugs, ganglion blockers), with strophanthin, a sharp increase in their effect is possible.

Analogues of the medicinal drug Complamin

Structural analogs for the active substance:

• Xanthinal nicotinate.

Analogues of the drug Complamine on the pharmacological group (antiaggregants):

• Agapurin;
• Agregal;
• Alprostadil;
• Arbiflex;
• Aspen;
• Brilint;
• Ventavis;
• Vixipine;
• Ginkyo;
• Ginos;
• Payment;
• Detromb;
• Doxylek;
• Zilt;
• Ibustrin;
• Integrilin;
• Cardiocipine;
• Kardogrel;
• Clopidogrel;
• Clopilet;
• Collorite;
• Xantinol nicotinate;
• Courantil;
• Lapal;
• Listab;
• Lopyrel;
• Myristin;
• Monophram;
• Muse;
• Parsedil;
• Pentylin;
• Pentoxifylline;
• Pentomer;
• Persantin;
• Pidogrel;
• Plavix;
• Plagril;
• Plyglare;
• Radomine;
• Ralofect;
• Rutziromab;
• Sanomil;
• Tagren;
• Target;
• Tikagrelor;
• Tyclid;
• Ticlo;
• Trenpental;
• Trental;
• Troken;
• Thrombogard;
• Thromboreductin;
• Thromboreal;
• Flexitale;
• Fluder;
• Cilostazol;
• Eikonol;
• Eyferol;
• Eifitol;
• Emoxibel;
• Emoxipine;
• Effective.

Surgeon's doctor's opinion

I use the drug Complamine as part of complex therapy for the treatment of patients with bedsores, poorly healing wounds and trophic ulcers of the lower limbs. I want to note that after the appointment of Complenin, the positive dynamics during these diseases are observed much earlier than without using it. Patients with severe lesions of the skin and underlying tissues are given parenteral administration of the drug, and for mild ulcers and bedsores they receive the drug in a pellet. Of the side effects most often noted weakness, dizziness and pain in the stomach.

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