En DE FR ES PL
Hepasol Neo - instructions for use, reviews, analogs and forms of release (injections in ampoules for injections, 8% infusions) of the drug for the treatment of liver cirrhosis, hepatic insufficiency, coma in adults, children and pregnancy. Composition

Hepasol Neo - instructions for use, reviews, analogs and forms of release (injections in ampoules for injections, 8% infusions) of the drug for the treatment of liver cirrhosis, hepatic insufficiency, coma in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drugHepasol Neo. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Hepasol Neo in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Hepasol Neo in the presence of existing structural analogues.Use for the treatment of cirrhosis of the liver, liver failure, coma, protein-energy deficiency in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

 

Hepasol-Neo - combined preparation for parenteral nutrition. It has a hepatoprotective and detoxification effect, takes part in metabolic processes. The composition of the drug includes all 8 essential amino acids, 2 conditionally replaceable amino acids (L-arginine and L-histidine), which are synthesized in insufficient quantities in some pathophysiological conditions, and 5 interchangeable amino acids that provide adequate metabolism in patients with liver diseases. Amino acids are in L-form, which allows their direct participation in the biosynthesis of proteins. Hepasol-Neo allows you to correct amino acid disorders in liver failure, as well as significantly improve the tolerance of proteins in patients with cirrhosis and hepatitis and reduce the severity of symptoms of hepatic encephalopathy.

 

Composition

 

L-valine + L-isoleucine + L-lysine mono-acetate + L-methionine + L-threonine + L-phenylalanine + L-tryptophan + L-alanine + L-arginine + Glycine + L-histidine + L-proline + L-serine + Acetylcysteine ​​+ excipients.

 

Pharmacokinetics

 

Infusion introduced amino acids pass one of two possible metabolic pathways: an anabolic pathway in which amino acids are linked by peptide bonds and form specific proteins, and the catabolic pathway in which transamination of amino acids occurs.

 

Introduced in the framework of complete parenteral nutrition along with glucose and fats (ratio of carbohydrates and fats 70 to 30) at a rate of 10.5 mg of Nitrogen per kilogram per hour, the amino acids reach a balanced concentration in the blood after 3 hours.

 

Metabolism of amino acids occurs in all tissues of the body. The degree of their splitting depends on the severity of the stress to which the organism is exposed. Stress accelerates the metabolism of amino acids and enhances the dysfunction of the liver, which for its part reduces the metabolism of amino acids. Sepsis also speeds up their metabolism, and a decrease in kidney function - suppresses.

 

Amino acids can be excreted unchanged with a rapid increase in their concentration in the blood. The half-life of amino acids (in healthy people) is 5-15 minutes (in this short time period, amino acids should be used for the synthesis of proteins).Remains of amino acids, unused during the synthesis of proteins, are subject to deamination, during which urea is formed, which is excreted from the body. With the infusion of Hepasol-Neo, the percentage of assimilation of essential acids is 99%, and the interchangeable - 97%. In this case, the total and renal clearance of essential amino acids is 0.5 liters per minute, that is, 1.5 ml per minute, and for most substitutable amino acids - 0.6 liters per minute, that is, 3 ml per minute. Arginine is almost completely reabsorbed in the renal tubules.

 

Indications

  • therapy and parenteral nutrition (partial or complete - with the addition of solutions of carbohydrates and fatty emulsions);
  • if liver function (liver failure) is disturbed with or without brain function (hepatic encephalopathy);
  • therapy of hepatic coma and precomatric states.

 

Forms of release

 

Injections in ampoules for injections, infusions 8% 500 ml.

 

Instructions for use and dosing regimen

 

Set individually, taking into account the concentration of ammonia in the blood and the severity of the disease.

 

Hepasol Neo is injected intravenously at a rate of 1-1.25 ml per kilogram of body weight per hour (30-35 drops per minute), which corresponds to 0.08-0.1 g of amino acids per kilogram per hour).The maximum rate of administration is 1.25 ml per kg per hour (0.1 g of amino acids per kg per hour, respectively).

 

The maximum daily dose is 18.75 ml per kg of body weight (1.5 g of amino acids per kg per day), that is, 1300 ml for patients with a body weight of 70 kg.

 

The duration of therapy is set individually until the complete disappearance of the neurological symptomatology.

 

Side effect

 

When used according to the indications in the recommended doses, the side effects of this drug are unknown.

 

Contraindications

  • disorders of metabolism (metabolism) of amino acids;
  • hyperhydration (excess water content in the body);
  • hyponatremia (low sodium in the blood);
  • hypokalemia (low concentration of potassium ions in the blood);
  • renal failure (in hepatic coma in patients with renal insufficiency, it is necessary to consider which of the two conditions threatens the life of the patient);
  • heart failure (in the stage of decompensation);
  • pregnancy;
  • lactation period;
  • children and adolescents under 18 years of age (efficacy and safety not established);
  • hypersensitivity to the components of the drug.

 

Application in pregnancy and lactation

 

Efficacy and safety of the drug Hepasol Neo during pregnancy and lactation are not established. The use of the drug in this category of patients is contraindicated.

 

Use in children

 

Contraindicated in children and adolescents under the age of 18 years (efficacy and safety not established).

 

special instructions

 

The use of a solution of Hepasol Neo is advisable only for the above indications.

 

During the application of this drug, periodic monitoring of the electrolyte and acid-base state, the degree of hydration of the body, the state of kidney function is necessary.

 

Use only a clear solution from an intact vial!

 

Drug Interactions

 

There are data on the interaction of the components of Hepasol Neo with theophylline, which leads to an increase in clearance.

 

There are numerous data on the interaction in vitro, so it is not recommended to add other drugs to the solution of Hepasol-Neo.

 

The solution of Hepasol-Neo is compatible with antibiotics - amikacin, ampicillin, cefotaxime, ceftriaxone, doxycycline, erythromycin, gentamicin, chloramphenicol, clindamycin, netilmicin, penicillin, piperacillin, tetracycline,tobramycin and vancomycin, as well as with aminophylline, cyclophosphamide, cimetidine, cytarabine, digoxin, dopamine, famotidine, phytomenadione, fluorouracil, folic acid, furosemide, heparin, chlorpromazine, insulin, calcium gluconate, lidocaine, methyldopa, methylprednisolone, metoclopramide, methotrexate, morphine , nizatidine, norepinephrine, propranolol, Ranitidine and riboflavin.

 

Analogues of the drug Hepasol Neo

 

Structural analogs for the active substance:

  • Aminoven;
  • Aminoplasmal;
  • Aminosol Neo;
  • Aminosteryl;
  • Dipeptivny;
  • Neframin;
  • Nephrotect;
  • Polyamine;
  • Heimiks.

 

Analogues for the pharmacological group (proteins and amino acids in combinations, agents for enteral and parenteral nutrition in combinations):

  • Aminocrovin;
  • Intralipid;
  • Infuzamine;
  • Inphezole;
  • Ketoaminol;
  • Kabiven;
  • Lipovenosis;
  • Lipoplus;
  • Lipofundin;
  • Moriamin;
  • Neframin;
  • Nutriflex;
  • Oliklinomel;
  • Omegavan.

 

Review of a hepatologist

 

The drug Hepasol Neo is considered the best of the analogs prescribed for liver failure. The drug is characterized by a high Fisher coefficient and high biological value.I apply it for cirrhosis of the liver, hepatic coma, hepatic encephalopathy, acute / chronic form of hepatitis. Included in the composition of Hepasol Neo essential amino acids effectively restore urea synthesis and metabolism. One of the drawbacks of the drug is the inability to use it in pregnancy, breast-feeding and for children under 18 years of age.

Similar medicines:

Other medicines:

Reviews (0):

Rules for publishing reviews and visitor questions