Heferol - instructions for use, analogs, reviews and release forms (capsules or tablets 350 mg) drugs for the treatment and prevention of iron deficiency, anemia in pregnancy, bleeding, chronic diarrhea in adults and children. Composition and alcohol
In this article, you can read the instructions for using the drugHeferol. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Heferol in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Heferol in the presence of existing structural analogues.Use for the treatment and prevention of iron deficiency, anemia in pregnancy and breastfeeding, bleeding, chronic diarrhea in adults and children. The composition of the drug and its interaction with alcohol.
Heferol - antianemic agent, contains ferrous iron in the form of iron fumarate. Iron is a microelement that stimulates erythropoiesis. When iron is used in the form of salts, its deficiency in the body is rapidly replenished, which leads to a gradual regression of clinical (weakness, fatigue, dizziness, tachycardia, tenderness and dry skin) and laboratory symptoms of anemia.
Composition
Iron fumarate + excipients.
Pharmacokinetics
When ingestion has a high absorption and bioavailability. It is absorbed mainly in the duodenum and the proximal part of the jejunum. Binding to proteins is 90% or more (mainly with hemoglobin). Deposited in the form of ferritin or hemosiderin in hepatocytes and reticuloendothelial system, a small amount - in the form of myoglobin in the muscles. In healthy people about 10-15% of the dose taken internally is absorbed. With iron deficiency, the absorption increases to 25-30%.From the body is excreted in minimal amounts by the kidneys, as well as with feces and bile. In the lactation period, about 0.25 mg per day enter the mother's milk.
Indications
Latent or clinically pronounced iron deficiency (iron deficiency anemia), developed as a result of:
- bleeding, including ulcerative lesions of the mucous membrane of the gastrointestinal tract (GIT);
- menorrhagia (severe bleeding during menstruation);
- metrorrhagia (bloody discharge, not associated with menstruation);
- bleeding with hemorrhoids;
- nasal bleeding;
- blood loss during surgical interventions;
- increased need for an organism in the gland (during pregnancy, breastfeeding, during intensive growth and puberty);
- violations of iron absorption from the digestive tract (with chronic diarrhea);
- inadequate intake of iron from food;
- donations.
Forms of release
Capsules 350 mg (sometimes mistakenly called pills).
Instructions for use and dosing regimen
Hepherol should be taken orally, on an empty stomach, 30 minutes before breakfast, with plenty of liquid. Adults and children over 12 years of age - 1 capsule per day (prophylaxis), 2 capsules per day in 1-2 doses (treatment). The course of treatment is 6-12 weeks.The drug is continued for 3-4 months after the normalization of the blood picture.
Side effect
- nausea, vomiting;
- hyperemia of the face;
- headache, dizziness;
- feeling of pressure behind the sternum;
- weakness, malaise;
- pain or discomfort in the epigastric (below the sternum) area;
- staining the feces black;
- diarrhea or constipation;
- transient (transient) decrease in blood pressure (BP);
- tachycardia (increased heart rate);
- allergic reactions of varying severity (rash, itching, anaphylactic shock);
- with prolonged unjustified use - hemosiderosis (excessive deposition of hemosiderin in the tissues of the body).
Contraindications
- hypersensitivity to iron preparations;
- hemosiderosis;
- sideroachrestic anemia (including lead anemia);
- anemia not related to iron deficiency (eg, hemolytic anemia, megaloblastic anemia caused by a lack of vitamin B12);
- diverticulum of the intestine, intestinal obstruction;
- regular blood transfusion;
- simultaneous therapy with parenteral iron preparations.
Application in pregnancy and lactation
There are no negative effects of Heferol on the fetus (per child) when the drug is used during pregnancy and breastfeeding.
Use in children
Contraindicated in children under 12 years.
special instructions
With caution apply for peptic ulcer disease of the stomach and duodenum, inflammatory bowel diseases (enteritis, diverticulitis, ulcerative colitis, Crohn's disease), alcoholism, bronchial asthma, hepatic or renal insufficiency, rheumatoid arthritis, blood transfusion.
To avoid the appearance of constipation, the drug should be washed down with plenty of liquid.
If taking the drug causes pain in the epigastrium, it should be taken with food.
Reception of Heferol and Tetracycline (or ciprofloxacin) is recommended to be divided in time.
Drug Interactions
Specific antidote of Heferol - deferoxamine.
Antacids, calcium preparations, ethidron, drugs that reduce the acidity of gastric juice (including histamine H2-receptor blockers, M-cholinolytics, proton pump inhibitors, preparations containing carbonates, bicarbonates, phosphates, oxalates), pancreatin,pancrelipase reduce the absorption of Hepherol, so it should be taken 1 hour before or 2 hours after their use.
Ascorbic acid increases absorption.
Iron fumarate reduces the absorption of fluoroquinolones, penicillamine, tetracyclines (they are recommended to be taken 2 hours before or 2 hours after taking iron preparations).
Large doses of iron drugs reduce intestinal absorption of zinc preparations (the latter is recommended to be taken 2 hours after taking iron preparations).
Ethanol (alcohol) increases absorption and the risk of toxic complications.
Eggs, milk, coffee, tea reduce the absorption of iron from the digestive tract.
Analogues of the drug Heferol
Structural analogs for the active substance:
- The iron fumarate;
- Ferronat.
Analogues of the drug Heferol by pharmacological group (stimulators of hemopoiesis):
- Irondekst;
- Actyferrin;
- Aloe syrup with iron;
- Aranesp;
- Argeferr;
- Aeprin;
- Biofer;
- Venofer;
- Wialfer;
- Hemofer;
- Granogen;
- Deoxynate;
- Iron gluconate;
- The iron fumarate;
- Iron sulfate;
- Zarcio;
- Cosmofer;
- Lonquex;
- Maltofer;
- Maltofer Foul;
- Mamifol;
- Mircera;
- Monofer;
- Neutrostim;
- Neostimium;
- Panagen;
- Pentoxyl;
- Polydane;
- The Revolade;
- Recormon;
- Sorbitrim;
- Sorbifer;
- Tardiferon;
- Tevagrastim;
- Totem;
- Fenyuls;
- Ferinzhekt;
- Ferlatum;
- Ferretab;
- Ferrinate;
- Ferro Folgamma;
- Ferronal;
- Ferronat;
- Ferroplex;
- Ferrum Lek;
- Filerim;
- Folic acid;
- Cyanocobalamin;
- Epokrin;
- Epomax;
- Eporati;
- Epostim;
- Epoetin;
- Eprex;
- Eralfon;
- Erythropoietin.
Response of a therapist
The drug Heferol - a good affordable tool for the treatment of iron deficiency anemia, the causes of which are very often bleeding nasal, uterine, during surgery and others. Therefore, I appoint Heferol to patients suffering from diseases with ulcerative lesions of the intestinal mucosa, to women with dysfunctional uterine bleeding. With anemia of mild and moderate severity, the hemoglobin level usually rises to the age norm by the end of the first month of taking the drug. But I advise my patients to take the medicine for another two months after the normalization of blood counts. This is necessary to fix the effect and to prevent the recurrence of iron deficiency.
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