Tiklid - instructions for use, reviews, analogs and formulations (250 mg tablets) of the drug for the prevention of thrombosis and the formation of thrombi, the treatment of angina in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Tyclid. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Tiklid in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Tiklid in the presence of existing structural analogues. Use for the prevention of thrombosis and the formation of blood clots, the treatment of angina in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Tyclid antiplatelet agent.Oppresses adhesion and inhibits 1 and 2 stages of platelet aggregation caused by adenosine phosphate (ADP). Promotes disaggregation. Inhibits also the aggregation of erythrocytes and affects their ability to deform. Reduces the blood levels of factor 4 and beta-thromboglucin. The mechanism of action on aggregation is presumably due to the fact that ticlopidine (the active substance of the drug Tyclide), interacting with glycoprotein 2b / 3a, interferes with the binding of fibrinogen to activated platelets.

Composition

Ticlopidine + excipients.

Pharmacokinetics

Tiklid quickly and almost completely absorbed, creates a maximum level in the plasma 2 hours after injection. The equilibrium concentration in the plasma is reached after 7-10 days. The average half-life in the equilibrium state is about 30-50 hours. Metabolised in the liver. 50-60% is excreted by the kidneys.

Indications

• prevention of thrombosis and the formation of blood clots in ischemic disorders caused by an atherosclerotic process in the vessels of the brain (cerebral atherosclerosis) and lower limbs;
• unstable angina;
• rehabilitation period after myocardial infarction and subarachnoid hemorrhage;
• condition after blood transfusion;
• prophylaxis of thrombus formation after cardiac bypass grafting and with the use of artificial circulation;
• in diabetes mellitus for the prevention of early retinopathy, nephroangiopathy and angiopathy of the lower extremities.

Forms of release

Tablets 250 mg.

Instructions for use and dosing regimen

The therapeutic dose is 250-500 mg per day, take the pill during or after a meal. If necessary, the dose is increased to 1 g per day under the control of the state of the blood coagulation system. The duration of treatment is set individually.

Side effect

• diarrhea;
• pain in the stomach;
• increased level of transaminases;
• Cholestatic (due to stagnation of bile) jaundice;
• hemorrhagic phenomena;
• Thrombocytopenia, leukopenia, agranulocytosis, neutropenia;
• skin rash;
• noise in ears.

Contraindications

• hemorrhagic diathesis;
• blood diseases accompanied by prolonged bleeding time;
• pathological conditions with a tendency to bleeding (peptic ulcer of the stomach and duodenum);
• hemorrhagic strokes in acute and subacute period;
• liver disease;
• leukopenia, thrombocytopenia and agranulocytosis in the anamnesis;
• the use of heparin in high doses;
• hypersensitivity to ticlopidine;
• pregnancy;
• lactation (breastfeeding).

Application in pregnancy and lactation

Tiklid is contraindicated in pregnancy and lactation.

Use in children

In pediatric practice, the drug is not used.

special instructions

Do not use simultaneously with anticoagulants and other antiplatelet agents (including acetylsalicylic acid).

Before the start of treatment, during the therapy (every 2 weeks for the first 3 months) and 15 days after discontinuation of treatment (if therapy is canceled within the first 3 months), a clinical blood test with counting of platelets and other blood elements is necessary. In case of severe neutropenia or thrombocytopenia, as well as in the manifestation of the effects of neutropenia (fever, sore throat, ulceration of the oral mucosa), thrombocytopenia (prolonged or unusual bleeding, bruising, purpura, dark feces) and hemolysis (jaundice,dark urine, lightly colored feces), treatment should be discontinued, and control blood tests should be performed before the normalization of the indices.

Be wary appoint patients with impaired liver function.

Tiklid should be canceled 1 week before scheduled operations.

Drug Interactions

With simultaneous use with antacids, with glucocorticosteroids (GCS), the effect of ticlopidine decreases.

With simultaneous use with anticoagulants, there is a risk of bleeding due to a combination of anticoagulant and antiaggregant activity; with acenocoumarol - it is possible to reduce the anticoagulant effect of acenocoumarol; with Acetylsalicylic acid - antiaggregant activity increases.

With simultaneous application with warfarin, cases of liver damage are described. The anticoagulant effect of Warfarin does not change.

With simultaneous use, it is possible to reduce excretion from the body and increase the concentration of theophylline in the blood plasma.

With simultaneous application, the clearance of phenazone decreases.

With the simultaneous use of Tiklid with phenytoin, the concentration of phenytoin in the blood plasma increases and the risk of its side effect increases.

With simultaneous application, cases of a decrease in the concentration of cyclosporine and Digoxin in blood plasma are described.

Analogues of the drug Tyclid

Structural analogs for the active substance:

• Aclotine;
• Tagren;
• Ticlo.

Analogues of the drug Tiklid on the pharmacological group (antiaggregants):

• Agapurin;
• Agregal;
• Aclotine;
• Alprostadil;
• Arbiflex;
• Aspen;
• Aspirin Cardio;
• Brilint;
• Vixipine;
• Ginkyo;
• Ginos;
• Payment;
• Detromb;
• Dipyridamole;
• Doxylek;
• Zilt;
• Ibustrin;
• Integrilin;
• Cardiocipine;
• Kardogrel;
• Cardutol;
• Klapitaks;
• Clopidex;
• Clopidogrel;
• Clopilet;
• Collorite;
• Complymine;
• Xantinol nicotinate;
• Courantil;
• Lapal;
• Lirta;
• Listab;
• Lopyrel;
• Myristin;
• Monophram;
• Muse;
• Parsedil;
• Pentamon;
• Pentoxifylline;
• Pentomer;
• Persantin;
• Pidogrel;
• Plavix;
• Plagril;
• Plyglare;
• Radomine;
• Ralofect;
• Rutziromab;
• Tagren;
• Target;
• Tikagrelor;
• Ticlo;
• Trental;
• Thrombogard;
• Thromboreductin;
• Thromboreal;
• Flexitale;
• Fluder;
• Cilostazol;
• Eikonol;
• Eyferol;
• Eifitol;
• Emoxibel;
• Emoxipine;
• Effective.

Response of a cardiologist

His patients who underwent an acute myocardial infarction or who suffer from unstable angina pectoris,to prevent the formation of thrombi, I prescribe the drug Tiklid. For the same purpose, it receives three patients who underwent a bypass operation. The daily dose of Tiklid is almost all 500 mg, that is, they take 1 tablet 2 times a day. The patients are well tolerated, no adverse reactions were seen in any of them. In isolated cases there were changes in blood tests: a slight decrease in the number of leukocytes and platelets. But about a month after the end of the treatment, hematological indicators came back to normal.

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