Bystrumcaps - instructions for use, analogs, reviews and release forms (capsules or tablets 200 mg) medication for pain relief in neuralgia, arthrosis, lumbago, menstruation in adults, children and pregnancy. Composition and alcohol

In this article, you can read the instructions for using the drug Bystrumcaps. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Bystrumkaps in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues Bystrumkapsa with existing structural analogues. Use for pain relief in neuralgia, arthrosis, lumbago, menstruation in adults, children, as well as during pregnancy and lactation.Composition and interaction of the drug with alcohol.

Bystrumcaps - non-steroidal anti-inflammatory drug (NSAID) from the group of propionic acid derivatives. Has anti-inflammatory, analgesic, antipyretic effect. It inhibits the aggregation of platelets. All of the above properties are a consequence of the reduction of prostaglandin synthesis, by a non-selective inhibition of the activity of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes.

Composition

Ketoprofen + auxiliary substances.

Pharmacokinetics

The release of Ketoprofen from granules with controlled release of the active substance occurs gradually in the gastrointestinal tract (GIT). After oral administration ketoprofen is almost completely absorbed from the digestive tract, it has the effect of "first passage" through the liver. Do not cum in the body. Eating does not affect the overall bioavailability of ketoprofen. Ketoprofen binds to plasma proteins by 99%, penetrates into the synovial fluid, where it reaches a higher concentration than in plasma. In a small amount, it penetrates the placental barrier.Metabolized in two main ways: by hydroxylation and by combining with glucuronic acid. It is excreted by the kidneys in the form of metabolites (up to 99%), of which 65-75% are metabolites of glucuronic acid, and with feces (1-8%).

Indications

Diseases of the musculoskeletal system and pain syndrome of different genesis:

• symptomatic treatment of inflammatory-degenerative diseases of the musculoskeletal system (bursitis, synovitis, capsulitis, tendinitis, periarthritis);
• articular syndrome (rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, spondylarthrosis) - for symptomatic therapy, pain and inflammation decrease at the time of use, the progression of the disease is not affected;
• pain in the lower back and spine (neuralgia, myalgia, sciatica, lumbago, lumboschialgia);
• post-traumatic pains (uncomplicated injuries, in particular sports, ligament and tendon injuries, bruises);
• postoperative pain;
• pain with dysmenorrhea.

Forms of release

Capsules 200 mg of prolonged action (sometimes mistakenly called pills).

Instructions for use and dosing regimen

Adults and adolescents over 15 years of age are prescribed 1 capsule (200 mg) once a day with meals.

Side effect

• NSAID-gastropathy;
• heartburn;
• nausea, vomiting;
• diarrhea, constipation;
• flatulence (bloating);
• decreased appetite;
• stomatitis (inflammation of the oral mucosa);
• stomach ache;
• changes in the activity of transaminases (hepatic enzymes);
• change in taste;
• hepatitis (inflammation of the liver);
• ulceration of the mucosa of the gastrointestinal tract;
• gingival, nasal, hemorrhoidal, vaginal bleeding;
• perforation (perforation) of the intestine;
• cystitis (inflammation of the bladder);
• urethritis (inflammation of the urethra);
• impaired renal function;
• acute renal insufficiency;
• interstitial nephritis (inflammation of the kidney tissue);
• nephrotic syndrome;
• hematuria (blood in the urine);
• edema (especially in patients with hypertension);
• excitation, nervousness;
• drowsiness;
• depression, asthenia;
• headache, dizziness;
• sleep disturbance, insomnia;
• noise in ears;
• confusion or loss of consciousness;
• forgetfulness;
• migraine;
• peripheral neuropathy (peripheral nerve damage);
• heart failure;
• increased blood pressure (BP);
• tachycardia (increased heart rate);
• allergic reactions: rhinitis, angioedema, anaphylactic shock, rash, itching, urticaria,asthmatic attack, especially in patients with hypersensitivity to acetylsalicylic acid, as well as to other drugs from the NSAID group;
• dermatological reactions: photosensitization, alopecia, erythema multiforme, erythema multiforme exudative, including Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome);
• anemia, leukopenia, thrombocytopenia, agranulocytosis, pancytopenia, hemolytic anemia (rarely);
• reversible toxic amblyopia (decreased vision, in which one of the two eyes is almost (or in general) not involved in the visual process;
• unclear vision or double vision;
• conjunctivitis, dryness of the eye mucosa;
• Pain in the eyes;
• hearing loss;
• increased sweating;
• hemoptysis;
• muscle twitching;
• dyspnea;
• thirst.

If any side effects occur, stop taking the medication immediately.

Contraindications

• bronchial asthma, rhinitis or urticaria in history caused by ketoprofen, acetylsalicylic acid or other NSAIDs;
• peptic ulcer of the stomach and duodenum in the phase of exacerbation;
• ulcerative colitis in the phase of exacerbation;
• Crohn's disease;
• diverticulitis (an intestinal disease characterized by inflammation of blindly terminating protrusions of its wall - diverticula);
• peptic ulcer;
• hemophilia and other disorders of blood clotting;
• active gastrointestinal, cerebrovascular and other bleeding (or suspicion of bleeding);
• severe renal failure (creatinine clearance (CK) less than 30 ml per minute);
• progressive kidney disease;
• severe hepatic impairment or active liver disease;
• condition after aortocoronary bypass surgery;
• confirmed hyperkalemia;
• inflammatory bowel disease;
• children's age till 15 years;
• 3 trimester of pregnancy;
• lactation period (breastfeeding);
• hypersensitivity to ketoprofen, other NSAIDs, or to any component of the drug.

Application in pregnancy and lactation

The drug Bystrumkaps is contraindicated in the third trimester of pregnancy and during lactation. With caution should prescribe the drug in the 1 and 2 trimesters of pregnancy.

Use in children

Contraindicated in children and adolescents under 15 years.

Application in elderly patients

Elderly Bystrumkaps should be used with caution.

special instructions

With caution: anemia, bronchial asthma, alcoholism, tobacco smoking, alcoholic liver cirrhosis, hyperbilirubinemia, hepatic insufficiency, dehydration, sepsis, chronic heart failure, edema, arterial hypertension, blood diseases (including leukopenia), stomatitis, ischemic heart disease (CHD ), cerebrovascular diseases, dyslipidemia / hyperlipidemia, diabetes mellitus, peripheral arterial disease, CC less than 60 ml per minute, ulcerative gastrointestinal lesions in history, the presence of Helicobacter pylori infection (Helicobacter pylori pylori), prolonged use of NSAIDs, severe somatic diseases, simultaneous administration of oral glucocorticosteroids (including PKN) (including prednisolone), anticoagulants (including warfarin), antiaggregants (including clopidogrel), selective serotonin reuptake inhibitors (including number of citalopram, fluoxetine, paroxetine, sertraline), elderly age, pregnancy (1 and 2 trimesters).

During treatment, it is necessary to monitor the picture of peripheral blood and the functional state of the liver and kidneys.

If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the test.

Reception of ketoprofen can mask signs of an infectious disease.

If the kidney and liver function is impaired, a dose reduction and careful monitoring is necessary.

To reduce the risk of developing adverse events from the gastrointestinal tract, the minimum effective dose should be used as short a course as possible.

Impact on the ability to drive vehicles and manage mechanisms

During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Drug Interactions

When used simultaneously with other NSAIDs (including salicylates in high doses), oral anticoagulants, heparin, ticlopidine increases the risk of bleeding.If ketoprofen is needed, careful monitoring of the patient's condition should be carried out.

With a simultaneous application with lithium, the toxic level of lithium in the plasma rises. If necessary, during simultaneous use of lithium and ketoprofen preparations, and also after its termination, careful monitoring of lithium concentration in plasma should be made.

When used simultaneously with Methotrexate (at a dose of more than 15 mg per week), the risk of hematotoxicity increases. Intervals before and after taking methotrexate should be at least 12 hours from taking ketoprofen.

The drug Bystrumkaps enhances the effect of anticoagulants, antiaggregants, fibrinolytics, ethanol (alcohol), side effects of SCS and mineralocorticosteroids (MCS), estrogens.

Increases the concentration in the plasma of Verapamil and nifedipine.

Myelotoxic drugs increase the manifestation of hematotoxicity of the drug.

Reduces the hypotensive effect of beta-blockers.

Increases the risk of nephrotoxic effect of beta-blockers.

Increases the risk of nephrotoxic effects of cyclosporine and tacrolimus, especially in elderly patients.

Reduces the contraceptive effectiveness of intrauterine spirals.

Increases the risk of bleeding with thrombolytics.

With the simultaneous use of Bystrumcaps with diuretics and angiotensin converting enzyme (ACE) inhibitors, it is possible to reduce diuretic and hypotensive effects and the risk of developing renal failure in patients with circulating blood volume (BCC) deficiency.

When used simultaneously with pentoxifylline, the risk of bleeding increases.

With simultaneous use with zidovudin increases the risk of anemia (affects reticulocytes with the development of anemia).

With simultaneous use reduces the effectiveness of uricosuric drugs.

When used simultaneously with GCS, ethanol (alcohol), corticotropin increases the risk of ulceration and the development of gastrointestinal bleeding and the development of violations of kidney function.

With simultaneous use with cefoperazonom, cefamandol and cefotetan increases the risk of bleeding.

With simultaneous use increases the hypoglycemic effect of insulin and oral hypoglycemic drugs (dose recalculation is necessary).

With simultaneous application increases the production of hydroxylated active metabolites by inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants).

With simultaneous use with sodium valproate, it disrupts the aggregation of platelets.

Antacids and colestyramine reduce the absorption of ketoprofen.

Analogues of drug Bystrumcaps

Structural analogs for the active substance:

• Arketal;
• Arthrosylen;
• Artrum;
• Bystrumgel;
• Valusal;
• Ketonal;
• Ketoprofen;
• Ketosphere;
• OCI;
• Oruvel;
• Pentalgin;
• Profenide;
• Spazgel;
• Fastum;
• Febrofide;
• Flamax;
• Fleksen.

Analogues of the drug Bystrumkaps on the pharmacological group (NSAIDs - derivatives of propionic acid):

• Advance;
• Advance;
• Aliv;
• Apranaks;
• Arthrosylen;
• ArthroCam;
• Artrum;
• Bonifen;
• Brustan;
• Brufen;
• Bystrumgel;
• Vimovo;
• Deblock;
• Dexalgin;
• Dexonal;
• Dolgit;
• Ibuklin;
• Ibuprofen;
• Ibusan;
• Ibutop;
• Ibufen;
• Iprene;
• Ketodexal;
• Ketonal;
• Ketoprofen;
• Ketosphere;
• Maxiokold;
• MOMENT;
• Motrin;
• Nalgezin;
• Nalfon;
• Naprios;
• Naprobeene;
• Naproxen;
• Neboline;
• Next;
• Novigan;
• Novospaz;
• Nurofen;
• Oruvel;
• Pedee;
• Pentalgin;
• Pronaxen;
• Profenide;
• Sanaprox;
• Sedalgin;
• Solpaflex;
• Spazgel;
• Surgham;
• Faspik;
• Fastum;
• Febrofide;
• Flamadex;
• Fleksen;
• Flugalin;
• Hyrumat.

Review of the neurologist's doctor

My patients, suffering from neuralgia and neuritis, lumbago and sciatica, radiculopathy often ask them to prescribe medication that quickly and permanently relieves pain. I prescribe them a drug Bystrumkaps. It is very convenient that you take capsules once a day. Patients say that if they take the medicine in the morning during breakfast, then it is valid for the whole working day. And even in the evening painful sensations do not always appear. There are side effects during treatment with Bystrumcaps. The most frequent of them in my practice is heartburn and nausea, dizziness, insomnia. There were cases of mild skin allergic reactions.

Similar medicines:

Other medicines: