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Leucomax - instructions for use, reviews, analogs and forms of release (injections in ampoules for injection of lyophilizate) drugs for the treatment of leukopenia in oncology, HIV infection, aplastic anemia in adults, children and pregnancy. Composition

Leucomax - instructions for use, reviews, analogs and forms of release (injections in ampoules for injection of lyophilizate) drugs for the treatment of leukopenia in oncology, HIV infection, aplastic anemia in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Leucomax. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of medical experts on the use of Leucomax in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Leucomax in the presence of existing structural analogues.Use to treat leukopenia in oncology, HIV infection, aplastic anemia in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

 

Leucomax - recombinant human granulocyte-macrophage colony-stimulating factor, similar in effect to the corresponding endogenous compound. It is a non-glycosylated water-soluble protein. Stimulates proliferation and differentiation of myeloid precursors of blood cells, accelerates the formation of granulocytes and macrophages, increases their functional activity. Increases the content of leukocytes in the blood, mainly neutrophils.

 

Composition

 

Molgraimost + auxiliary substances.

 

Pharmacokinetics

 

After subcutaneous administration, the maximum serum albumin concentration is achieved after 3-4 hours. With a single administration, the effect develops after 1-4 hours; the maximum is reached within the range of 6 to 18 hours. Half-life of the mnogramostim after intravenous administration is 1-2 hours and after subcutaneous administration - 2-3 hours.

 

Indications

 

Treatment and prevention of leukopenia, including agranulocytosis and neutropenia:

  • when carrying out anti-tumor chemotherapy;
  • in patients with myelodysplastic syndrome;
  • in patients with aplastic anemia;
  • when bone marrow transplantation;
  • with various infections (including HIV infection);
  • with neutropenia caused by ganciclovir, in the treatment of cytomegalovirus retinitis in AIDS patients.

 

Forms of release

 

Liofilizate for solution for injection 50 mcg, 150 mcg, 300 mcg, 400 mcg, 700 mcg, 1500 mcg (injections in ampoules).

 

Instructions for use and dosing regimen

 

Leukomax injected intravenously or subcutaneously - from 1 to 10 μg per 1 kg of body weight per day. The maximum daily dose is 10 μg per 1 kg. The solution is prepared immediately before administration by dissolving the powder in pyrogen-free or sterile water.

 

Side effect

  • anorexia (obsessive desire to lose weight, fear of obesity);
  • nausea, vomiting;
  • diarrhea;
  • stomach ache;
  • stomatitis (inflammation of the oral mucosa);
  • convulsions;
  • myalgia (pain in the muscles);
  • asthenia (increased fatigue with extreme mood instability, weakened self-control, sleep disturbance, loss of ability for prolonged mental and physical stress, intolerance of loud sounds, bright light, sharp odors;
  • headaches, dizziness;
  • confusion of consciousness;
  • increased intracranial pressure;
  • disorders of cerebral circulation;
  • arterial hypotension;
  • fainting;
  • heart rhythm disturbances;
  • heart failure;
  • pulmonary edema;
  • increased capillary permeability;
  • exudative pericarditis (inflammation of the outer shell of the heart);
  • exudative pleurisy (inflammation of the membrane covering the lungs);
  • shortness of breath, bronchospasm (decrease of bronchial lumen);
  • edema;
  • fever;
  • pain in the bones;
  • nonspecific pain in the chest;
  • increased sweating;
  • decrease in the number of platelets, hemoglobin and serum albumin level;
  • rash, itching;
  • angioedema (edema of Quincke);
  • anaphylactic shock;
  • pain in the injection site.

 

Contraindications

  • myeloid leukemia;
  • increased sensitivity to molgamostimu.

 

Application in pregnancy and lactation

 

In pregnancy, the use of Leukomax is possible only on strict indications. If it is necessary to use molgamostim during lactation, it is recommended to stop breastfeeding.

 

Use in children

 

Contraindicated for children and adolescents under 18 years.

 

Specials indications

 

Caution is used in patients with leukomax autoimmune diseases, lung diseases.

 

Treatment with a molramostim should be carried out under the supervision of a doctor who has experience in the use of such drugs. In the process of treatment, control of the picture of peripheral blood, control of the level of albumin in the blood is necessary.

 

If severe hypersensitivity reactions develop (anaphylactic shock, angioedema, bronchospasm), exudative pleurisy, exudative pericarditis, treatment is discontinued.

 

Drug Interactions

 

The decrease in the albumin level in the plasma, caused by the action of the molramostim, can be exacerbated by its simultaneous use with preparations characterized by high binding to albumin.

 

Analogues of medicinal preparation Lejkomaks

 

Structural analogs for the active substance:

  • Neostimium.

 

Analogues of Leucomax on pharmacological group (stimulators of hemopoiesis):

  • Irondekst;
  • Actyferrin;
  • Argeferr;
  • Aeprin;
  • Betaleukin;
  • Binocrit;
  • Biofer;
  • Venofer;
  • Wialfer;
  • Vitamin B12;
  • Hemofer;
  • Granogen;
  • Granocyte;
  • Grazalva;
  • Deoxynate;
  • The iron fumarate;
  • Zarcio;
  • The Immigra;
  • CosmoFer;
  • Leukogen;
  • To the Leichest;
  • Lonquex;
  • Maltofer;
  • Mamifol;
  • Myelastra;
  • Mozobail;
  • Monofer;
  • Neupogen;
  • Neutrostim;
  • Unstable;
  • Normosang;
  • Panagen;
  • Pentoxyl;
  • Polydane;
  • The Revolade;
  • Recormon;
  • Sorbitrim;
  • Sorbifer;
  • Tardiferon;
  • Tevagrastim;
  • Totem;
  • Fenyuls;
  • Ferinzhekt;
  • Ferlatum;
  • Ferretab;
  • Ferrinate;
  • Ferro-Folgamma;
  • Ferrograduum;
  • Ferronal;
  • Ferroplex;
  • Ferrum Lek;
  • Filgrastim;
  • Fitin;
  • Folacin;
  • Heferol;
  • Ceruloplasmin;
  • Cyanocobalamin;
  • Epokrin;
  • Eporati;
  • Epoetin;
  • Eprex;
  • Eralfon;
  • Erythropoietin.

 

Review of a hematologist

 

The preparation Lejkomaks I appoint or nominate to patients with oncologic diseases which it is necessary to pass or take place a course of a chemotherapy. The purpose of this medication is the prevention of leukopenia, which often develops in patients during the administration of chemotherapeutic agents. But to prevent a decrease in the number of neutrophils in the blood can not always be, so you have to use Leukomax and to fight with leukopenia. Carry the drug all in different ways. But adverse reactions occur in almost every case. This and nausea with pain in the abdomen, and pain in the muscles and bones, and heart rhythm disturbances.

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