Lanzoptol - instructions for use, analogs, reviews and release forms (capsules or tablets 30 mg) of the drug for the treatment of stomach and duodenal ulcers, GERD, Zollinger-Ellison syndrome in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Lansoptol. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Lanzoptol in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Lansoptol in the presence of existing structural analogues.Use for the treatment of stomach and duodenal ulcers, gastroesophageal reflux disease or GERD, Zollinger-Ellison syndrome in adults, children, as well as in pregnancy and lactation. Composition of the preparation.

Lansoptol - antiulcer, specific proton pump inhibitor, hydrogen-potassium adenosine triphosphatase (H / K-ATPase) enzyme. Metabolized in parietal cells of the stomach to active sulfonamide derivatives that inactivate the sulfhydryl groups of H + / K + -ATPase. It blocks the final stage of synthesis of hydrochloric acid, reducing basal and stimulated secretion, regardless of the nature of the stimulus. The inhibition of production of hydrochloric acid at a dose of 30 mg - 80-97%. Does not affect the motility of the gastrointestinal tract (GIT). Inhibitory effect increases in the first 4 days of admission. After stopping the intake, the acidity remains below 50% basal level for 30 hours, there is no ricochetial increase in secretion. Secretory activity is restored 3-4 days after the end of the drug. In patients with Zollinger-Ellison syndrome, lanzoptol acts more persistently.

Composition

Lansoprazole + auxiliary substances.

Pharmacokinetics

After ingestion, absorption is high. Eating lowers absorption of Lansoptol and bioavailability, but the inhibitory effect on gastric secretion remains the same regardless of food intake. Binding to plasma proteins - 97,7-99,4%. It is actively metabolized by the "first pass" through the liver. It is excreted by the kidneys in the form of metabolites (14-23%) and through the intestines. With hepatic insufficiency and in elderly patients, excretion slows down.

Indications

• peptic ulcer of the stomach and duodenum;
• GERD (gastroesophageal reflux disease);
• reflux-esophagitis, erosive-ulcerative esophagitis;
• erosive and ulcerative lesions of the stomach and duodenum associated with the use of non-steroidal anti-inflammatory drugs (NSAIDs);
• stress ulcers;
• peptic ulcers;
• erosive and ulcerative lesions of the stomach and duodenum, associated with Helicobacter pylori (Helicobacter pylori) (as part of complex therapy);
• Zollinger-Ellison syndrome.

Forms of release

Capsules 30 mg (sometimes mistakenly called pills).

Instructions for use and dosing regimen

The drug is taken orally.With a single admission, it is preferable to take the drug in the morning, before breakfast, but it is possible to take the drug also in the evening, before supper. If necessary, twice the drug is prescribed before breakfast and before dinner. Capsules should be swallowed whole, not liquid. If you can not swallow a whole capsule, its contents can be mixed with a small amount of apple juice (about 1 full tablespoon) and swallowed without chewing. Possible introduction through the gastric tube.

With duodenal ulcer in the phase of exacerbation appoint 30 mg per day for 2-4 weeks, in resistant cases - up to 60 mg per day.

With gastric ulcer in the phase of exacerbation and erosive-ulcerative esophagitis - 30-60 mg per day for 4-8 weeks.

With erosive and ulcerative lesions of the gastrointestinal tract caused by the intake of NSAIDs, 30 mg per day for 4-8 weeks.

To eradicate Helicobacter pylori - 30 mg twice a day for 10-14 days in combination with antibacterial agents.

For anti-relapse treatment of peptic ulcer of the stomach and duodenum - 30 mg per day.

For anti-relapse treatment of reflux-esophagitis - 30 mg per day for a long time (up to 6 months).

In Zollinger-Ellison syndrome, the dose is set individually until the level of basal secretion is less than 10 mmol per hour. A starting dose of 60 mg once a day is recommended. If you need to take a daily dose of 120 mg it is recommended to divide it into 2 divided doses. The duration of Lanzoptol therapy is determined by the doctor.

Side effect

• increased or decreased appetite;
• nausea, abdominal pain;
• diarrhea or constipation;
• ulcerative colitis;
• Candidiasis of the gastrointestinal tract;
• increased activity of hepatic enzymes;
• increase of bilirubin in the blood;
• headache;
• malaise, dizziness;
• drowsiness;
• depression, anxiety;
• cough;
• pharyngitis (inflammation of the mucous membrane of the pharynx);
• rhinitis (runny nose);
• upper respiratory infections;
• influenza-like syndrome;
• thrombocytopenia (with hemorrhagic manifestations), anemia;
• skin rash;
• alopecia (baldness);
• Myalgia (pain in the muscles).

Contraindications

• malignant neoplasms in the digestive tract;
• 1 trimester of pregnancy;
• lactation period (breastfeeding);
• age to 18 years;
• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

Lansoptol is contraindicated for use in the first trimester of pregnancy and during lactation.

Caution should be given to the drug during pregnancy (2 and 3 trimesters).

Use in children

Contraindicated in children and adolescents under the age of 18 years.

Application in elderly patients

Caution should be given to elderly patients.

special instructions

Before the start of treatment, it is necessary to exclude the presence of malignant process in the upper GI tract, as taking the drug can mask the symptoms and make diagnosis more difficult. Therefore, mandatory endoscopic control is recommended before and after treatment.

With caution, it is necessary to take Lanzoptol for patients with severe liver disease and elderly people; with a maximum daily dose of 30 mg.

Dose changes for patients with kidney disease are not required.

Lanzoptol contains sucrose, so the drug is not recommended for patients with hereditary intolerance to fructose, glucose malabsorption syndrome and / or galactose, a deficiency of sucrose isomaltase.

Impact on the ability to drive vehicles and manage mechanisms

In recommended doses, the drug does not affect the speed of psychomotor reactions and concentration of attention.

Drug Interactions

With the simultaneous use of lansoprazole slows the excretion of drugs metabolized in the liver by microsomal oxidation (including diazepam, phenytoin, indirect anticoagulants).

Lansoptol reduces the clearance of theophylline by 10%.

Lansoprazole changes the pH-dependent absorption of drugs belonging to weak acid groups (deceleration) and bases (acceleration).

Sucralfate reduces the bioavailability of lansoprazole by 30% (the interval between taking these drugs should be 30-40 minutes).

Antacids slow down and reduce the absorption of Lansoptol, so antacids should be prescribed for 1 hour or 1-2 hours after taking lansoprazole.

Analogues of the drug Lanzoptol

Structural analogs for the active substance:

• Acrylase;
• Lanzabel;
• Lanzap;
• Lansoprazole;
• Lansofed;
• Lancid;
• Loenzar;
• Epicurus.

Analogues of the drug Lanzoptol for the pharmacological group (proton pump inhibitors):

• Acrylase;
• Beret;
• Vimovo;
• Gastrozole;
• Dexylant;
• Demeprazole;
• A zerocide;
• Zipantola;
• Zolser;
• Zulbeks;
• Controllers;
• Chrismel;
• Crosatide;
• Lanzabel;
• Lanzap;
• Lansoprazole;
• Lansofed;
• Lancid;
• Losek;
• Nexium;
• Neo-text;
• Nolpaz;
• Omal;
• Omesol;
• Omez;
• Omeprazole;
• Omepros;
• Omeface;
• Omizak;
• OmiPix;
• Omitox;
• Ontime;
• Ortanol;
• Ozid;
• Pantaz;
• Pantoprazole;
• Panum;
• Parries;
• Pepazol;
• Pepticum;
• Pienenum;
• Pylobact;
• Pomez;
• Puloreph;
• Rabelock;
• Rabeprazole;
• Rabiet;
• Razo;
• Romesque;
• Sunpras;
• Ulzol;
• Ulcozol;
• Ulter;
• Ultop;
• Hirabesol;
• Helithrix;
• Helicid;
• Helol;
• Cisagast;
• Esomeprazole;
• Emanera;
• Emesol;
• Epicurus.

Recall of a gastroenterologist

I prescribe Lanzoptol as part of complex therapy for patients suffering from peptic ulcer and / or duodenal ulcer during the exacerbation of the disease. If the patient faithfully performs medical appointments, observes the dosing regimen of Lanzoptol and the duration of its administration, as a rule, there is always a pronounced positive dynamics. Improves overall health, pain and discomfort disappear in the abdomen, and appetite is restored. Patients well tolerate the treatment of Lansoptol, there were no pronounced side effects on this drug in my practice.

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