Gerperax - instructions for use, reviews, analogs and forms of release (200 mg tablets, 5% ointment) for the treatment of herpes, chicken pox, cytomegalovirus and shingles in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Gerperax. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Herperax in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Gerperax in the presence of existing structural analogues.Use for the treatment of herpes, chicken pox, shingles and cytomegalovirus infection in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Gerperax antiviral agent. Thymidine kinase of virus-infected cells actively converts Acyclovir (the active substance of the Herperax preparation) through a series of consecutive reactions into the mono-, di- and triphosphate of acyclovir. The latter interacts with the viral DNA polymerase and is embedded in DNA, which is synthesized for new viruses. Thus, "defective" viral DNA is formed, which leads to suppression of replication of new generations of viruses.

Acyclovir is active against the Herpes simplex virus types 1 and 2, the Varicella zoster virus, the Epstein-Barr virus and cytomegalovirus. With herpes, prevents the formation of new elements of the rash, reduces the likelihood of cutaneous dissemination and visceral complications, accelerates the formation of crusts, reduces pain in the acute phase of herpes zoster. It has an immunostimulating effect.

Composition

Acyclovir + excipients.

Pharmacokinetics

When administered, the bioavailability is 15-30%.Widely distributed in tissues and body fluids. Binding to plasma proteins is 9-33%. Metabolised in the liver. It is excreted in the urine, in a small amount - with feces.

Indications

• infections caused by viruses of herpes simplex (Herpes simplex) types 1 and 2 (oral and genital herpes);
• infections caused by the virus Varicella zoster (chickenpox and herpes zoster);
• cytomegalovirus disease;
• keratitis and other eye injuries caused by the Herpes simplex virus;
• skin infections caused by viruses Herpes simplex and Varicella zoster;
• prevention of infections caused by the viruses Herpes simplex and Varicella zoster (including in patients with reduced immunity);
• complex therapy with severe immunodeficiency (including in the clinical picture of HIV infection) and in patients who underwent bone marrow transplantation;
• prevention of cytomegalovirus infection after bone marrow transplantation.

Forms of release

Tablets 200 mg: 30 pieces.

Ointment for external use 5%: tube 5 g.

Instructions for use and dosing regimen

Inside adults and children over 2 years - 200-400 mg 3-5 times a day, if necessary - 20 mg per kg (up to 800 mg per reception) 4 times a day. Children under 2 years of age are given a dose equal to half the dose for adults.Duration of treatment - 5-10 days. In case of renal failure, correction of the dosing regimen is recommended.

Locally and externally apply 5 times a day. The dose and duration of treatment depend on the indications and the dosage form used.

Side effect

Pills:

• nausea, vomiting;
• diarrhea;
• abdominal pain;
• skin rash;
• headache;
• dizziness;
• increased fatigue;
• decreased concentration of attention;
• hallucinations;
• drowsiness or insomnia;
• fever;
• loss of hair (rarely);
• transient increase in blood concentrations of bilirubin, urea, creatinine, activity of hepatic enzymes;
• lymphocytopenia (low number of lymphocytes in the blood);
• erythropenia (low number of erythrocytes in the blood);
• leukopenia (a decrease in the number of leukocytes per unit volume of blood).

Ointment:

• burning of the skin in the place of application (application of ointment);
• superficial point keratitis (inflammation of the cornea of ​​the eye);
• blepharitis (inflammation of the eyelids);
• conjunctivitis (inflammation of the conjunctiva of the eye);
• skin rash, itching;
• erythema (redness);
• dry skin, peeling;
• inflammation (on contact with mucous membranes).

Contraindications

• increased sensitivity to acyclovir or valacyclovir.

Application in pregnancy and lactation

The use of Herperax during pregnancy is possible in cases where the intended use for the mother exceeds the potential risk to the fetus. In experimental animal studies, it has been shown that acyclovir penetrates the placental barrier.

The drug penetrates into breast milk. Herperax should be administered to nursing women with caution, only if necessary.

Use in children

Inside children older than 2 years - 200-400 mg 3-5 times a day, if necessary - 20 mg per kg (up to 800 mg per reception) 4 times a day. Children under 2 years of age are given a dose equal to half the dose for adults. Duration of treatment - 5-10 days.

Application in elderly patients

Treatment of elderly patients should be carried out with sufficient increase in water load and under the supervision of a physician, since in this category of patients the half-life of acyclovir is increased.

special instructions

It is not recommended for use in severe renal dysfunction.

It should be borne in mind that with the use of Gerperax, the development of acute renal failure is possible due to the formation of a precipitate of acyclovir crystals,which is especially possible with the simultaneous use of nephrotoxic drugs, in patients with impaired renal function and with insufficient water load.

When using acyclovir, it is necessary to monitor the kidney function (determining the level of urea Nitrogen in the blood and creatinine in the blood plasma).

In the treatment of genital herpes, sexual intercourse should be avoided or condoms should be used. the use of acyclovir does not prevent the transmission of the virus to partners.

Ointment Gerperax should not be applied to the mucous membranes of the oral cavity, eyes, vagina. In the treatment of ophthalmic ointment, contact lenses should not be worn.

Drug Interactions

With the simultaneous use of probenecid reduces the tubular secretion of Herperax and thereby increases the concentration in the blood plasma and the half-life of the drug.

With simultaneous application with mycophenolate mofetil increases the total concentration of acyclovir in plasma and the inactive metabolite of mycophenolate mofetil.

With the simultaneous use of acyclovir with nephrotoxic drugs, the risk of developing nephrotoxic action increases (especially in patients with impaired renal function).

Analogues of medicinal product Gerperax

Structural analogs for the active substance:

• Acigerpine;
• Acyclovir;
• Acyclostad;
• Vivorax;
• Virolex;
• Gervirax
• Gerpevir;
• Herpes;
• Zovirax;
• Lysavir;
• The Medovar;
• Provirsan;
• Supperan;
• Cyclouvax
• Cyclovir;
• Cycloviral;
• Cytivir.

Analogues on the curative effect (antiherpetic drugs):

• Allisarin ointment;
• Amiksin;
• Anaferon;
• Anaferon child;
• Antigerpes;
• Antioxidant-lacry;
• Arbidol;
• Acyclovir;
• Valwyr;
• Walogard;
• Valtrex;
• Valtsikon;
• Vectavir;
• Virazole;
• Virdep;
• Virolex;
• Virosept;
• Vitalhardvak;
• Viferon;
• Wobe-Mugos E;
• Galavit;
• Gevisos;
• Gerpevir;
• Herpes;
• Herpferon;
• Groprinosin;
• Devirs;
• Zovirax;
• Isoprinosine;
• Immunomax;
• Interferon alfa-2 recombinant ointment on a hydrogel basis;
• Kagocel;
• Kipferon;
• Lavomax;
• Lysavir;
• Lycopid;
• Lomagherpan;
• Lorinden S;
• Sodium nucleate;
• Neovir;
• Panavir;
• Superantitox 100;
• Supperan;
• Tyqveol;
• Famvir;
• Fenistil Pencivir;
• Ferrovir;
• Cyclovax;
• Cyclovir;
• Cycloviral;
• Cycloferon;
• Cytivir;
• Epigenum sex;
• Erazaban;
• Ergoferon.

Response of a therapist

Not a bad budget product.Assign in the form of tablets with herpetic eruptions on the face, helps reduce the number of exacerbations per year. Ointment is ineffective, it can be used prophylactically, for example, after going to the dentist, when there are micro-trauma in the corners of the mouth. With a severe degree of herpes simplex, with genital localization or shingles, Valtrex shows itself better. Although it is more expensive, it acts stronger and faster.

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