Vizophryn - instructions for use, reviews, analogs and forms of release (eye drops and nose 2.5%) drugs for the treatment of colds, allergies, conjunctivitis in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Vizophrene. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Vizofrin in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Vizofrin in the presence of existing structural analogues. Use to treat colds, allergies, conjunctivitis and pharyngitis in adults, children, as well as during pregnancy and lactation.Composition of the preparation.

Visofrin - adrenomimetic. It has a direct stimulating effect mainly on alpha-adrenergic receptors. With systemic application, it causes narrowing of the arterioles, increases the overall peripheral vascular resistance (OPSS) and blood pressure (BP). Cardiac output does not change or decrease, which is associated with reflex bradycardia (increased vagal tone) in response to arterial hypertension. Phenylephrine (an active substance of the drug Vizophrene) raises blood pressure not so dramatically as norepinephrine and epinephrine, but it lasts longer. This is apparently due to the fact that phenylephrine is more stable and does not collapse under the influence of catechol-O-methyltransferase (COMT). With topical application phenylephrine has a pronounced vasoconstrictive effect, causes mydriasis (dilated pupil), can lower the intraocular pressure with open-angle glaucoma. In average therapeutic doses, it practically does not affect the central nervous system (CNS).

Composition

Phenylephrine hydrochloride + excipients.

Pharmacokinetics

After ingestion, phenylephrine is poorly absorbed from the digestive tract.Metabolized with the participation of MAO (monoamine oxidase inhibitors) in the intestinal wall and "first pass" through the liver. Bioavailability of phenylephrine is low. After topical application, it undergoes systemic absorption.

Indications

Inside and locally

• to reduce swelling of the mucous membrane of the nasopharynx;
• conjunctivitis for colds and allergic diseases (mainly in combination preparations).

Parenterally

• to increase blood pressure during collapse and arterial hypotension due to a decrease in vascular tone.

Forms of release

Eye drops and in the nose 2.5%

Instructions for use and dosing regimen

When taken orally and topically applied, the dose depends on the indications and the dosage form used.

When administered subcutaneously or intramuscularly, a single dose is 2-5 mg, then, if necessary, 1-10 mg. When administered intravenously, a single-dose (slow) single dose is 100-500 μg. With intravenous infusion, the initial rate is 180 μg per minute, then, depending on the effect, it is reduced to 30-60 μg per minute.

Maximum doses

• for adults, when taken orally, a single dose of 30 mg, daily - 150 mg;
• subcutaneous or intramuscular single dose - 10 mg, daily - 50 mg;
• when administered intravenously, a single dose of 5 mg, daily - 25 mg.

Side effect

• undesirable prolonged blood pressure;
• tachycardia (increased heart rate);
• reflex bradycardia (decrease in heart rate);
• irritating effect on mucous membranes.

Contraindications

• arterial hypertension;
• severe atherosclerosis;
• propensity to spasms of coronary vessels;
• hypersensitivity to phenylephrine.

Application in pregnancy and lactation

Adequate and strictly controlled clinical studies of the safety of the use of Vizofrin during pregnancy and lactation were not conducted.

Use in children

With topical application after suction through the mucosa, Vizophrene can cause systemic effects. In this regard, the use of phenylephrine in the form of 10% eye drops in infants should be avoided.

special instructions

Avoid the use of Vizofrin in patients with severe hyperthyroidism. Use with caution in coronary heart disease (ischemic heart disease).

With topical application after absorption through the mucosa, phenylephrine can cause systemic effects. In this regard, the use of phenylephrine in the form of 10% eye drops in infants and elderly patients should be avoided.

Drug Interactions

When phenylephrine is used against a background of general anesthesia caused by halothane or cyclopropane, ventricular fibrillation may develop.

When used simultaneously with MAO inhibitors, potentiation of the effects of phenylephrine (including in topical application) is observed.

Phenothiazines, alpha-adrenoblockers (phentolamine), Furosemide and other diuretics reduce the vasoconstrictor effect of phenylephrine.

Guanethidine increases the mydriatic effect of phenylephrine (with systemic absorption).

Oxytocin, ergot alkaloids, tricyclic antidepressants, furazolidone, procarbazine, selegiline, sympathomimetics increase the pressor effect, and the latter - and arrhythmogenicity.

With simultaneous use of beta-adrenoblockers reduce cardiostimulating activity; against reserpine is possible arterial hypertension (due to the depletion of catecholamine stores in adrenergic neurons, the sensitivity tosympathomimetics).

Analogues of the drug Visofrin

Structural analogs for the active substance:

• Mesatone;
• Relief;
• Irifrin;
• Nasol;
• Neosinephrine;
• Irifrin;
• Phenylephrine;
• Stelphrine.

Analogues for the pharmacological group (alpha-adrenomimetics):

• Aldomet;
• Alfagan;
• Afrin;
• Bebifrin;
• Berberil;
• Briisolin;
• Vizin;
• Halazolin;
• Hemiton;
• Gutron;
• Dopanol;
• Dopegit;
• Influrin;
• Xylen;
• Xilobene;
• Xylometazoline;
• Ximelin;
• Lazolvan;
• Luxphen;
• Methyldopa;
• Montevizine;
• Nazivin;
• Naphthysine;
• Nesopin;
• Knoxprey;
• Oxymetazoline;
• Oxifrin;
• Otrivin;
• Risaxyl;
• Rhinomaris;
• Rinonorm;
• Rhinorus;
• Rhinostop;
• Sanorin;
• Tisaloud;
• Tizanidine;
• Tizanil;
• Tysine;
• Triméks;
• Fazin;
• Fatal;
• Pharmazoline;
• Eucazoline;
• Espazolin;
• Estulik.

Response of a therapist

Vizofrin is an effective drug for removing the symptom complex accompanying rhinitis, pharyngitis, conjunctivitis of various nature. The use of drops facilitates the condition with a cold, removes inflammation and swelling, effectively eliminates nasal congestion. Assign it to patients with chronic and allergic rhinitis, with colds.The use of the drug can cause systemic effects, so drops can not be used to treat infants, elderly patients. At pregnancy and feeding by a breast them too do not appoint or nominate.

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