Ingavirin - instructions for use, reviews, analogs and forms of release (30 mg capsules, 60 mg and 90 mg capsules) for treatment of influenza and ARVI in adults, children and pregnancy. Composition
In this article, you can read the instructions for using the drug Ingavirin. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Ingavirin in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Ingavirin in the presence of existing structural analogues. Use to treat influenza and ARVI in adults, children, as well as during pregnancy and lactation.
Ingavirin - antiviral drug. Active against influenza A viruses (A / H1N1, incl."Pig" A / H1N1 swl, A / H3N2, A / H5N1) and type B, adenovirus infection, parainfluenza, respiratory syncytial virus infection.
The antiviral mechanism of action is associated with the suppression of virus reproduction at the nuclear phase, delayed migration of the newly synthesized NP virus from the cytoplasm to the nucleus.
Has a modulating effect on the functional activity of Interferon system: cause elevation of blood physiological norm to interferon, stimulates and normalises reduced alpha interferonprodutsiruyuschuyu capacity of blood leukocytes, stimulates gamma interferonprodutsiruyuschuyu ability of leukocytes.
Causes the generation of cytotoxic lymphocytes and increases the content of NK-T cells, which have a high killer activity with respect to virus transformed cells and marked antiviral activity.
The anti-inflammatory effect is due to inhibition of the production of key proinflammatory cytokines (FNOalfa, IL-1beta and IL-6), a decrease of myeloperoxidase activity.
Therapeutic efficacy with influenza and other acute respiratory viral infections (ARVI) manifested in shortening the period of fever, decrease of toxicity (headache, weakness, dizziness), catarrhal symptoms,reduction in the number of complications and duration of the disease.
Pharmacokinetics
When used in recommended doses, the determination of the drug in blood plasma by available techniques is not possible. In experimental studies using a radioactive label, it was found that the drug quickly enters the blood from the digestive tract and is evenly distributed throughout the internal organs. With a 5-day course of oral intake of the drug 1 time per day, it accumulates in the internal organs and tissues. It is not metabolized in the body and is excreted unchanged. The main elimination process occurs within 24 hours. During this time, 80% of the dose is output. 77% of them are excreted in feces, 23% - with urine.
Composition
Imidazolylethanamide pentanedioic acid (vitaglutam) + auxiliary substances.
Indications
- treatment of influenza A and B and other ARI (adenovirus infection, parainfluenza, respiratory syncytial infection).
Forms of release
Capsules 30 mg, 60 mg and 90 mg.
Forms in the form of tablets do not exist in nature, perhaps the drug in this form is a fake of the original Ingavirin.
Instructions for use and dosing regimen
Caspuly 90 mg
The drug should be taken orally, regardless of food intake, 90 mg once a day for 5-7 days (depending on the severity of the condition).
The drug should be taken from the moment the first symptoms appear, preferably no later than 36 hours after the onset of the disease.
Capsules 60 mg
To treat influenza and acute respiratory viral infections, children from 7 to 17 years are prescribed 1 capsule (60 mg) once a day. Duration of treatment is 5-7 days (depending on the severity of the condition). The drug should be taken from the moment the first symptoms appear, preferably no later than 2 days after the onset of the disease.
Side effect
- allergic reactions.
Contraindications
- pregnancy;
- children under 7 years (for capsules 60 mg), children and adolescents under 18 years (for capsules 90 mg);
- deficiency of lactase, lactose intolerance;
- hypersensitivity to the components of the drug.
Application in pregnancy and lactation
The use of the drug in pregnancy has not been studied.
If you need to use the drug during lactation, you should decide whether to stop breastfeeding.
Ingavirin does not affect reproductive function, does not have embryotoxic and teratogenic effects.
special instructions
Experimental toxicological studies have shown a low level of toxicity and a high profile of drug safety (LD50 exceeds the therapeutic dose by more than 3000 times).
The drug does not have mutagenic, immunotoxic, allergic and carcinogenic properties, does not have a local irritant effect.
With regard to the joint administration of the drug and alcohol, standard recommendations, or, more precisely, a ban on simultaneous reception, are in effect. The combined action of ethanol and Ingavirin has not been studied.
Impact on the ability to drive vehicles and manage mechanisms
Ingavirin does not have a sedative effect, does not affect the speed of the psychomotor reaction, the drug can be used in persons of various professions, including. requiring increased attention and coordination of movements.
Drug Interactions
It is not recommended simultaneous use of Ingavirin with other antiviral drugs.
There were no cases of interaction of Ingavirin with other drugs.
Analogues of Ingavirin
Structural analogs for the active substance:
- Vitaglutam;
- Dicarbamine.
On the mechanism of action (antiviral effect):
- Actipol;
- Alpisarin;
- Algiers;
- Alfaferon;
- Amizon;
- Amiksin;
- Arbidol;
- Arpetolide;
- Arpefly;
- Acyclovir;
- Betaferon;
- Bonaphoton;
- Valaciclovir;
- Virazole;
- Gevisos;
- Grippferon;
- Groprinosin;
- Isoprinosine;
- Interferon;
- Inferon;
- Lavomax;
- Midantan;
- Neovir;
- Oxolin;
- Orvire;
- Panavir;
- Relenza;
- Remantadine;
- Ribavirin;
- Tamiflu;
- Thilaxin;
- Tyloron;
- Famciclovir;
- Extavia;
- Erazaban.
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