Ibuprom - instructions for use, reviews, analogs and forms of release (capsules or tablets 200 mg) of the drug for the treatment of colds, headaches and toothaches, lowering the temperature in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Ibuprom. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Ibuprom in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Ibuprom in the presence of existing structural analogues. Use to treat colds, headaches and toothaches, reduce temperature in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Ibuprom - a non-steroidal anti-inflammatory drug (NSAID), a derivative of phenylpropionic acid. Has anti-inflammatory, analgesic and antipyretic effect. The mechanism of action is associated with oppression of the activity of COX, the main enzyme of arachidonic acid metabolism, which is the precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever. The analgesic effect is caused both by peripheral (indirectly, through suppression of prostaglandin synthesis) and by the central mechanism (inhibition of the synthesis of prostaglandins in the central and peripheral nervous system). Suppresses the aggregation of platelets. Reduces the morning stiffness, promotes an increase in the volume of movements in the joints.

Composition

Ibuprofen + excipients.

Pharmacokinetics

When ingestion Ibuprofen is almost completely absorbed from the digestive tract. Simultaneous food intake slows down the rate of absorption. Metabolised in the liver (90%). Half-life is 2-3 hours. 80% of the dose is excreted in the urine mainly in the form of metabolites (70%), 10% - in unchanged form, 20% is excreted through the intestine in the form of metabolites.

Indications

• rheumatoid and rheumatoid arthritis;
• ankylosing spondylitis;
• osteoarthritis;
• articular syndrome with exacerbation of gout;
• psoriatic arthritis;
• tendonitis;
• bursitis;
• radiculitis;
• traumatic inflammation of soft tissues and musculoskeletal system;
• neuralgia;
• myalgia;
• pain syndrome in infectious and inflammatory diseases of ENT organs, adnexitis;
• algodismenorea;
• headache and toothache;
• fever in infectious and inflammatory diseases.

Forms of release

Capsules or tablets 200 mg.

Instructions for use and dosing regimen

Established individually, depending on the nosological form of the disease, the severity of clinical manifestations. When administered or rectally for adults, a single dose is 200-800 mg, the frequency of admission is 3-4 times a day; for children - 20-40 mg per kilogram per day in several receptions. The maximum daily intake for adults with oral or rectal administration is 2.4 grams.

Side effect

• nausea, vomiting;
• anorexia (pathological desire to lose weight);
• feeling of discomfort in the stomach;
• diarrhea;
• erosive and ulcerative lesions of the gastrointestinal tract;
• bleeding from the digestive tract;
• violations of the liver;
• headache;
• dizziness;
• sleep disorders;
• excitation;
• visual impairment;
• anemia (low concentration of hemoglobin);
• thrombocytopenia (decrease in the number of platelets);
• agranulocytosis (a decrease in the level of leukocytes due to granulocytes and monocytes, which increases the susceptibility of the organism to bacteria and fungi);
• impaired renal function;
• skin rash;
• Quincke's edema (extensive swelling of the subcutaneous tissue, fasciae, muscles);
• aseptic meningitis (inflammation of the membranes of the brain and spinal cord caused by viruses);
• bronchospasm (lack of air, severe shortness of breath).

Contraindications

• erosive and ulcerative lesions of the gastrointestinal tract in the phase of exacerbation;
• diseases of the optic nerve;
• intolerance to aspirin;
• polyps of the nose;
• bronchial asthma;
• disorders of hematopoiesis;
• severe renal or hepatic impairment;
• third trimester of pregnancy;
• hypersensitivity to ibuprofen.

Application in pregnancy and lactation

The use of Ibuprom in the third trimester of pregnancy is contraindicated. The use in the first and second trimesters of pregnancy is justified only in those cases when the expected benefit for the mother exceeds the possible risk to the fetus.

Ibuprom in small amounts excreted in breast milk. Use in the lactation period for pain and fever is possible. If you need long-term use or use in high doses (more than 800 mg per day), you should decide whether to stop breastfeeding.

Use in children

Using Ibuprom for children requires strict adherence to the dosing regimen.

special instructions

Used with caution during concomitant liver and kidney diseases, congestive heart failure, with dyspeptic symptoms before treatment immediately after surgery, with indications of a history of bleeding from the gastrointestinal tract and gastrointestinal diseases, allergic reactions associated with taking NSAIDs.

In the process of treatment, systematic monitoring of liver and kidney functions, and peripheral blood patterns are necessary.

Drug Interactions

With simultaneous use of ibuprofen reduces the effect of antihypertensive drugs (ACE inhibitors, beta-blockers), diuretics (furosemide, hydrochlorothiazide).

With simultaneous use with anticoagulants, it is possible to enhance their effect.

With simultaneous application with GCS (glucocorticosteroids), the risk of side effects from the gastrointestinal tract increases.

With the simultaneous use of ibuprofen may displace from the compounds with blood plasma proteins, indirect anticoagulants (acenocumarol), hydantoin derivatives (phenytoin), oral hypoglycemic drugs derivatives of sulfonylureas.

With simultaneous use with amlodipine, a slight decrease in the antihypertensive effect of Amlodipine is possible; with Acetylsalicylic acid - the concentration of ibuprofen in blood plasma decreases; with Baclofen - a case of increasing the toxic effect of baclofen is described.

With simultaneous use with warfarin, an increase in bleeding time may be possible, microhematuria, hematomas were also observed; with Captopril - it is possible to reduce the antihypertensive effect of captopril; with colestyramine - a moderate decrease in absorption of ibuprofen.

With simultaneous application of lithium carbonate, the concentration of lithium in the blood plasma increases.

With the simultaneous use of magnesium hydroxide, the initial absorption of ibuprofen increases; with Methotrexate - the toxicity of methotrexate is increased.

Analogues of the drug Ibuprom

Structural analogs for the active substance:

• Advance;
• ArthroCam;
• Bonifen;
• Brudol;
• Brufen;
• Burana;
• Deblock;
• Motrin;
• Dolgit;
• Ibuprom Sprint Caps;
• Ibuprofen;
• Ibusan;
• Ibutop;
• Ibufen;
• Iprene;
• MOMENT;
• Maxiokold;
• Neboline;
• Next;
• Nurofen;
• Pedee;
• Sedalgin;
• Solpaflex;
• Faspik.

Analogues on the curative effect (means for relief of pain in the joint):

• Actasulide;
• Ambien;
• Amelotex;
• Anopyrine;
• Apizarthron;
• Arkoxy;
• Arthroxane;
• Arthrosan;
• Askalcin;
• Ascofen;
• Aspirin;
• Acifein;
• Aertal;
• Bengai
• Betalgon;
• Bethanicomylon;
• Biopin;
• Brustan;
• Beliefed;
• Viprosal;
• Voltaren;
• Grippostad;
• Humisol;
• Diklobene;
• Diclofenac;
• Dimexide;
• Capsicam;
• Ketanov;
• Ketonal;
• Ketoprofen;
• Ketorolac;
• Ketorol;
• Maxigan;
• Meloksikam;
• Migrenol;
• Naisylate;
• Nyz;
• Nemux;
• Nimesil;
• Oxadol;
• Oxycamox;
• Panadol;
• Paracetamol;
• Pentalgin;
• Pliwalgin;
• Protradon;
• Prohodol;
• Revalgine;
• Remetan;
• Spasgan;
• Spazmalgon;
• Teraflex;
• Tiapride;
• Tobitil;
• Upsarin of the UPSA;
• Feldoral;
• Flamadex;
• Flamax;
• Fleksen;
• Floiled;
• Flugalin;
• Hotemin;
• Citramon;
• Citrapar;
• Efferalgan;
• Yunispaz.

Response of a rheumatologist

Ibuprom is an effective analgesic. Its active ingredient ibuprofen well removes inflammation, anesthetizes, is characterized by a good antipyretic effect. I appoint Ibuprom at various degenerative-dystrophic diseases of joints and a backbone. This allows you to effectively remove the pain syndrome and improve the patient's quality of life. The preparation has many side effects, therefore it is forbidden to use it to avoid complications without the appointment of a doctor. Strict adherence to the dosing regimen is mandatory.

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