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Protexoxone - instructions for use, analogs, testimonials and release forms (tablets for implantation of 1 gram + 100 mg) of the drug for the treatment of drug addiction and opioid dependence in adults, children and pregnancy. Composition

Protexoxone - instructions for use, analogs, testimonials and release forms (tablets for implantation of 1 gram + 100 mg) of the drug for the treatment of drug addiction and opioid dependence in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Protektoxone. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Protexoxone in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Prodetoxone analogs in the presence of existing structural analogues. Use for the treatment of drug addiction and opioid dependence in adults, children,as well as during pregnancy and lactation. Composition of the preparation.

 

Protexone - a competitive antagonist of opioid receptors. This combination drug, which lasts for 8-10 weeks, contains an antagonist of opioid receptors, Naltrexone (the active ingredient of Prodetoxone) and a corticosteroid triamcinolone, designed to prevent a local inflammatory reaction in the implantation area.

 

Due to the main active substance of naltrexone, the drug competitively blocks the binding of agonists or displaces them from opioid receptors, affects opioid receptors of all types and prevents or eliminates the effect of exogenous opioids - opioid analgesics and their surrogates (including morphine, heroin). Reduces or removes symptoms caused by the use of opioids. Long-term use does not cause increased tolerance and dependence.

 

Composition

 

Naltrexone hydrochloride + triamcinolone acetonide + excipients.

 

Pharmacokinetics

 

After subcutaneous implantation of a dose of naltrexone 1 gram, the therapeutic concentration of naltrexone and 6-beta-naltrexol persists to 2 months.Metabolised in the liver with the formation of active metabolites, including 6-beta-naltrexol. It is excreted mainly with urine and with bile.

 

Indications

  • treatment of opioid dependence outside the withdrawal syndrome;
  • rehabilitation and prevention of relapse of opioid dependence.

 

Forms of release

 

Tablets for implantation (implant) 1 gram + 100 mg.

 

Instructions for use and dosing regimen

 

Prodetoxone tablets are intended for subcutaneous implantation.

 

Treatment of opioid dependence Prodetoksonom should start after 7-10 day abstinence from opioids and preparations containing them, or after any other way opioid detoxification with the presence of the confirmation of the exit of the withdrawal syndrome - the absence of opioids in the urine and a negative provocative test with naloxone.

 

Subcutaneous implantation is preferably performed in the subcutaneous fat of the anterior abdominal wall. After infiltration anesthesia with observance of the rules of aseptic and antiseptic in the place where the implant is supposed to be placed, a skin cut about 1.5 cm long is made. In a blunt way (using the "Bilroth" clamp), a channel is created to insert an implant about 5 cm in length.The syringe container is inserted into the canal until it reaches its distal end. With the aid of the piston, the implant is pushed out of the container and placed in the subcutaneous fat tissue, after which 1-2 dermal seams are inserted from the non-absorbable material. The seam is treated with an antiseptic solution, a sterile sticker is applied.

 

In the future, the change of the label is made every other day with the treatment of the joint site with antiseptic solutions. Sutures are removed 7-8 days after implantation.

 

If necessary, repeated implantation is possible. The duration of treatment and the number of repeated implantations is determined by the attending physician.

 

Side effect

  • decreased appetite;
  • nausea, vomiting;
  • diarrhea or constipation;
  • abdominal pain;
  • impaired liver function;
  • tachycardia (painful heart palpitations);
  • increased blood pressure;
  • phlebitis (inflammation of the venous wall);
  • headache;
  • weakness;
  • sleep disorders;
  • anxiety;
  • dizziness;
  • decreased mood;
  • dystrophic reactions;
  • nasal congestion;
  • cough;
  • labored breathing;
  • slowing of ejaculation;
  • decreased potency;
  • increased or decreased libido;
  • redness of the skin;
  • acne (acne);
  • itching;
  • local aseptic inflammation;
  • chills;
  • tremor (involuntary trembling of fingers);
  • joint pain;
  • enlarged lymph nodes;
  • exacerbation of hemorrhoids.

 

Contraindications

  • opioid withdrawal syndrome;
  • lack of data on the conduct of the provocative test with naloxone, indicating the withdrawal from the withdrawal syndrome;
  • positive test for the presence of opioids in urine;
  • acute hepatitis;
  • liver failure;
  • the Itenko-Cushing syndrome;
  • systemic fungal infections;
  • glaucoma;
  • osteoporosis;
  • pregnancy;
  • the period of breastfeeding;
  • children's age till 6 years;
  • hypersensitivity to opioid receptor blockers (naloxone and naltrexone preparations) in the history and other components of the drug, in particular, to triamcinolone.

 

Application in pregnancy and lactation

 

Contraindicated in the use of Prodetoxone in pregnancy and during breastfeeding.

 

Use in children

 

Do not use for children under 6 years.

 

special instructions

 

The drug should be used in specialized medical institutions under the supervision of a doctor.

 

Before use, liver failure should be ruled out, and the level of transaminases should be monitored periodically during treatment.

 

During treatment with Prodetoxone, if necessary, anesthesia for medical reasons (surgery, trauma) is preferably using non-opioid analgesics. In case of emergency analgesia, opioid analgesics should be cautious and prescribe opioids at a higher dose to overcome antagonism.

 

Patients should be warned:

  • when seeking medical help, the patient is obliged to inform medical workers about treatment with Prodetoxone;
  • when there are pains in the abdomen, darkening of the urine, yellowing of the sclera should consult a doctor;
  • when using heroin and other opioid drugs in small doses, the effect of their use will not be, and further increase in the dose of narcotic drugs can lead to a fatal outcome as a result of stopping breathing.

 

Drug Interactions

 

The combined use of prodecoxone with hepatotoxic drugs increases the risk of liver damage.

 

Possible increased drowsiness with the simultaneous use of Prodetoxone with thioridazine.

 

Analogues of the drug Prodetoxone

 

Structural analogues in the composition of the active substances do not have the drug Protexoxone.

 

Analogues for the pharmacological group (competitive opioid receptor antagonists):

  • Biotredin;
  • Limonar.

 

Analogues on the curative effect (funds for the treatment of opioid dependence):

  • Antakson;
  • Vero-Narcamp;
  • Vivitrol;
  • Galavit;
  • Naloxone;
  • Naltrexone;
  • Piracetam;
  • Pyrroxane;
  • Tiapride;
  • Trittico;
  • Truksal.

 

Recall of a narcologist

 

I prescribe Prodetoxone to patients who suffer from opioid dependence often. The main difference between the drug and its analogues is that it contains a corticosteroid triamcinolone, which helps to prevent the development of local inflammation in the field of implantation of tablets. After implantation, the symptomatology caused by the use of opioids is markedly reduced or completely eliminated. It is important that the use of Protexoxone does not cause addiction, during treatment the dependence is not formed.

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