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Mikroyodid - instructions for use, analogs, reviews and release forms (100 μg and 200 μg tablets) of the drug for the prevention and treatment of endemic goiter, the prevention of recurrence of goiter in adults, children and pregnancy. Composition

Mikroyodid - instructions for use, analogs, reviews and release forms (100 μg and 200 μg tablets) of the drug for the prevention and treatment of endemic goiter, the prevention of recurrence of goiter in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Mikroiodid. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Microroyidida in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Microroyodid in the presence of existing structural analogues. Use for the prevention and treatment of endemic goiter,prevention of recurrence of goiter after its surgical removal in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

 

Mikroiodid - a product containing inorganic iodine. On admission iodides in the follicle epithelial cells of the thyroid gland under the influence of iodide peroxidase enzyme occurs Iodine oxidation with the formation of elementary iodine which is included in the molecule of tyrosine. In this case, one part of the tyrosine radicals in thyroglobulin is iodinated. Iodinated tyrosine radicals condense into tyronines, the main of which are thyroxine (T4) and triiodothyronine (T3). The resulting complex thyronine and thyroglobulin released as deposited form of thyroid hormone, follicle in colloid and stored in this condition for several days or weeks. With iodine deficiency, this process is disrupted. Potassium iodide (the active substance of the drug Mikruodid), compensating for iodine deficiency, helps restore the broken synthesis of thyroid hormones.

 

With the normal content of iodine in the environment, the excess of iodides is inhibited by the biosynthesis of thyroid hormones and their release from thyroglobulin,decreases the sensitivity of the thyroid gland to the thyroid-stimulating hormone of the pituitary gland and blocks its secretion by the pituitary gland.

 

Composition

 

Potassium iodide + auxiliary substances.

 

Pharmacokinetics

 

When ingested quickly absorbed from the gastrointestinal tract. Widely distributed in all tissues and body fluids.

 

Indications

  • prevention of endemic, including diffuse and multinodular, goiter, associated with iodine deficiency;
  • prevention of recurrence of goiter after surgical removal;
  • treatment of diffuse euthyroid goiter in newborns, children, adolescents and adult patients of young age.

 

Forms of release

 

Tablets are 100 μg and 200 μg.

 

Instructions for use and dosing regimen

 

To prevent the development of endemic goiter, newborns and children are prescribed 50-100 micrograms of iodine per day, adolescents and adults receive 100-200 micrograms of iodine per day, women during pregnancy and during breastfeeding receive 150-200 micrograms of iodine per day.

 

For the prevention of recurrence of goiter after its surgical removal - 100-200 mcg of iodine daily.

 

When treating diffuse euthyroid goiter, newborns, children and adolescents are prescribed 100-200 micrograms of iodine per day, adult patients of young age - 300-500 micrograms of iodine per day.

 

The daily dose of the drug should be taken at one time, after eating, with plenty of liquid.

 

The duration of reception of the microfluids is determined by the doctor.

 

The use of the drug for prophylactic purposes is usually carried out for several months or years, and often for the whole life.

 

Children and adolescents usually require a course of treatment of 6 to 12 months.

 

Side effect

  • with prolonged use of the drug in high doses (more than 300 μg per day), the development of iodine-induced hyperthyroidism is possible (especially in elderly patients, with nodular goiter or toxic adenoma);
  • when iodine preparations are used in high doses (more than 1 mg per day), in certain cases development of goiter and hypothyroidism is possible;
  • reactions of hypersensitivity in combination with "iodine" rhinitis;
  • iododerma (skin lesion);
  • exfoliative dermatitis;
  • angioedema;
  • iodism, which can be manifested by a metallic taste in the mouth, swelling and inflammation of the mucous membranes (rhinitis, conjunctivitis, bronchitis), iodine fever, iodine acne, swelling of the salivary glands.

 

When applying Mikroyoidida according to the indications in the recommended doses, the development of side effects is unlikely.

 

Contraindications

  • severe thyrotoxicosis;
  • latent thyrotoxicosis (when applied at doses exceeding 150 μg per day);
  • herpetiform dermatitis;
  • toxic adenoma of the thyroid gland;
  • nodular goiter when used at doses of more than 300 μg per day (with the exception of preoperative therapy for the purpose of blocking the thyroid gland);
  • hypersensitivity to iodine.

 

Application in pregnancy and lactation

 

During pregnancy and lactation, the need for iodine increases.

 

Microiodide is prescribed according to the indications in those cases when the intake of iodine with food is less than 150-300 μg per day.

 

The drug penetrates well through the placental barrier and can cause the development of hypothyroidism and goiter in the fetus. Iodine is also excreted in breast milk. Therefore, during pregnancy and lactation (breastfeeding), the drug should be used only at recommended doses.

 

Use in children

 

Children and adolescents usually require a course of treatment of 6 to 12 months.

 

special instructions

 

On the background of therapy in patients with renal insufficiency, it is possible to develop hyperkalemia.

 

Microiodide should not be taken with hypothyroidism, except when the development of the latter is caused by a pronounced iodine deficiency.

 

It should avoid the appointment of the drug in therapy with radioactive iodine, the presence or suspected of thyroid cancer.

 

Drug Interactions

 

The effectiveness of treatment with thyreostatics with simultaneous intake of iodine decreases.

 

Potassium perchlorate and potassium thiocyanate inhibit the absorption of iodine by the thyroid gland. Thyrotropic hormone improves the absorption of iodine by the thyroid gland and stimulates the production of its hormones.

 

The use of iodine in high doses and simultaneous administration of potassium-sparing diuretics can lead to the development of hyperkalemia.

 

Simultaneous appointment of Microroyidid in high doses and lithium preparations promotes the development of goiter and hypothyroidism.

 

Analogues of the drug Mikruodid

 

Structural analogs for the active substance:

  • 9 months Potassium iodide;
  • Antistrum;
  • Iodine Vitrum;
  • Iodine Vitrum for children;
  • Iodobalance;
  • Iodide;
  • Iodomarine;
  • Iodistine;
  • Potassium iodide.

 

Analogues of the drug Mikruodid on the pharmacological group (hormones of the thyroid and parathyroid glands, their analogs and antagonists):

  • L-thyroxine;
  • Alostine;
  • Antistrum;
  • Bagotiroks;
  • Veprena;
  • Iodine Vitrum;
  • Iodine Vitrum for children;
  • Iodide;
  • Iodomarine;
  • Iodistine;
  • Iodotyrox;
  • Potassium iodide;
  • Calcitonin;
  • Calcitonin Depot;
  • L Tirok;
  • Levotiroksin sodium;
  • Mercazolyl;
  • Metizol;
  • Miakaltsik;
  • Microroyod;
  • Sodium levothyroxine;
  • Novotiral;
  • Osteover;
  • Parsabiv;
  • Propitsil;
  • Thiamazole;
  • Thyreocom;
  • Thyreotome;
  • Thiro 4;
  • Tirozol;
  • Triiodothyronine;
  • Eutiroks.

 

Review of the endocrinologist

 

I live and work in the region, endemic in goiter, where even in many food products (salt, bread, etc.), producers add iodine because of its deficiency. Therefore, iodine preparations, including Microiodide, are widely used in my practice. I appoint it with the goal of preventing relapses of the disease to patients who underwent surgery for a marked diffuse or nodular goiter. I prescribe mycroids for adolescents and young adults to prevent the development of endemic goiter in them. The medicine is well tolerated. In my practice there were no undesirable reactions to it.

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