Allomaron - instructions for use, analogs, reviews and release forms (tablets of 100 mg + 20 mg) drugs for the treatment of gout and hyperuricemia in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Allomaron. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Allomaron in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Allomaron analogs in the presence of existing structural analogs. Use for the treatment of gout and hyperuricemia (elevated levels of uric acid in the blood) in adults, children, as well as during pregnancy and lactation.Composition of the preparation.

Allomaron - a drug that affects the exchange of uric acid. Allomaron contains two active ingredients: Allopurinol and benzbromarone.

Allopurinol disrupts the synthesis of uric acid. It is a structural analogue of hypoxanthine. It inhibits the enzyme xanthine oxidase, which is involved in the conversion of hypoxanthine to xanthine and xanthine into uric acid. This is due to a decrease in the concentration of uric acid and its salts in the liquid media of the body and urine, which helps dissolve the existing urate deposits and prevents their formation in tissues and kidneys. When taking allopurinol, the excretion of urine hypoxanthine and xanthine increases.

Benzbromarone has a hypouricemic and uricosuric effect. Increases the excretion of uric acid by the kidneys, suppressing the reabsorption of uric acid in the renal tubules. To some extent suppresses the synthesis of purines.

Allomaron reduces the elevated level of uric acid in the blood plasma, eliminates and prevents its deposition, prevents kidney damage and gout attacks.

Composition

Allopurinol + Benzbromarone + auxiliary substances.

Pharmacokinetics

After taking the tablets, allopurinol is almost completely absorbed (90%) from the gastrointestinal tract (GIT). Metabolized with the formation of alloxanthin, which retains the ability to inhibit xanthine oxidase long enough. About 20% of the accepted dose of allopurinol is excreted through the intestine, the rest - by the kidneys. After ingestion, the absorption of benzbromarone from the gastrointestinal tract is incomplete. It is highly associated with plasma proteins. Metabolised in the liver and excreted mainly with feces, in small amounts determined in urine.

Indications

• Hyperuricemia (increased uric acid in the blood plasma) of different genesis;
• gout, including gouty arthritis.

Forms of release

Tablets coated with 100 mg + 20 mg.

Instructions for use and dosing regimen

Allomaron taken inside, 1-3 tablets a day after meals, with the mandatory intake of at least 1.5-2 liters of fluid per day (under the control of diuresis). Treatment should begin with 1 tablet a day with a gradual increase in dose.

Side effect

• gastrointestinal disorders, diarrhea;
• vasculitis (inflammation of blood vessels) with skin manifestations and fever;
• liver and kidney damage;
• change in the picture of blood (leukopenia, thrombocytopenia);
• allergic reactions.

Contraindications

• hypersensitivity to the components of the drug;
• hemochromatosis (hereditary, genetically determined disease, manifested by a violation of the exchange of iron with its accumulation in tissues and organs);
• severe renal dysfunction (with creatinine level in the serum above 132.6 μmol / l (1.5 mg / 100 ml) or with a glomerular filtration rate below 40 ml per minute);
• pregnancy;
• breast-feeding;
• age younger than 14 years.

Application in pregnancy and lactation

Allomaron is contraindicated in pregnancy and lactation.

Use in children

Contraindicated in children under 14 years.

special instructions

In severe renal impairment (serum creatinine level more than 1.5 mg% and glomerular filtration rate below 40 ml per minute) is not used. In these cases, allopurinol is recommended without benzbromarone.

Drug Interactions

Allomaron increases the toxicity of azathioprine and mercaptopurine, the anticoagulant effect of coumarin derivatives, lengthens the action of chlorpropamide.

Thiazide diuretics, derivatives of ethacrylic and salicylic acids reduce the effect of Allomaron (increase the level of uric acid in the blood).

When treatment with iron increases the accumulation of iron in the liver.

Analogs of Allomaron

Allomaron does not have structural analogs for the active substance.

Analogues for the pharmacological group (agents affecting the exchange of uric acid):

• Adenurik;
• Allopurinol;
• Allpol;
• Alopron;
• The dezurik;
• Clofezon;
• Colchicum-dispersant;
• Colchicine;
• Purinol;
• Sanfipourol;
• Phoebusostat.

Analogues on the curative effect (remedies for gout):

• Aknomid D;
• Allopurinol;
• Allpol;
• Alopron;
• Ambien;
• Apranaks;
• Arthrosylen;
• Arthromax;
• Beliefed;
• Voltaren;
• The dezurik;
• Dexamethasone phosphate;
• Diklobene;
• Dicluberl;
• Diqlovit;
• Diclomelan;
• Diclonac;
• Dicloran;
• Diclofen;
• Diclofenac;
• Diphene;
• Donalgin;
• Ibuprofen;
• Ibusan;
• Ilaris;
• Indomethacin;
• Kalmopyrene;
• Kenalog;
• Ketonal;
• Clynoril;
• Clofezon;
• Colchicine;
• Lemodus;
• Metindole;
• Nalfon;
• Naprios;
• Naproxen;
• Neurodiclavitis;
• Niflugel;
• Novolide;
• Oxycamox;
• Piroxicam;
• Piroximeter;
• Polcortolone;
• Revmavek;
• Revmadore;
• Remetan;
• Remoxicam;
• Reopyrin;
• Sanaprox;
• Sanfinak;
• Sanfipourol;
• Solpaflex;
• Susanorm;
• Tenikam;
• Tenoktil;
• Tilcotyl;
• Tobitil;
• Triamsinolone;
• Fastum gel;
• Feldoral;
• Feloran;
• Fleksen;
• Hotemin;
• Celeston;
• Cyston.

Response of a therapist

After graduation he worked in the therapeutic hospital of the city hospital, where he had experience prescribing Allomaron to patients with gout and patients with high uric acid content in the blood (without obvious clinical symptoms). I do not remember, that at them any side effects on this medicine were noted, all patients well transferred or tolerated therapy Allomaronom. Depending on the severity of hyperuricemia or the severity of gout, I chose the dose of the drug. Someone was enough 1 tablet a day to achieve positive dynamics of the disease. But some patients had to increase the dose to 3 tablets a day.

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