Vivorax - instructions for use, analogs, reviews and release forms (tablets 200 mg, ointment, cream) drugs for the treatment of herpes, immunodeficiency and prevention of cytomegalovirus infection in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Vivorax. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Vivorax in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues Vivoraxa in the presence of existing structural analogues. Use to treat herpes,immunodeficiency and prevention of cytomegalovirus infection in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Vivorax antiviral agent. Thymidine kinase of virus-infected cells actively converts Acyclovir (the active substance of the drug Vivorax) through a series of consecutive reactions to the mono-, di- and tri-phosphate of acyclovir. The latter is embedded in deoxyribonucleic acid (DNA), interacting with the viral DNA polymerase. This DNA is synthesized for new viruses. Thus, "defective" viral DNA is formed, which leads to suppression of replication of new generations of viruses. Acyclovir is active against the Herpes simplex virus types 1 and 2, the Varicella zoster virus, the Epstein-Barr virus and cytomegalovirus.

Composition

Acyclovir + excipients.

Pharmacokinetics

When administered, the bioavailability is 15-30%. Widely distributed in tissues and body fluids. Binding to plasma proteins is 9-33%. Metabolised in the liver. It is excreted in the urine, in a small amount - with feces.

Indications

• infections caused by viruses Herpes simplex (herpes) types 1 and 2 and Varicella zoster (chicken pox or chickenpox and shingles);
• prevention of infections caused by the viruses Herpes simplex and Varicella zoster (including in patients with reduced immunity);
• as part of complex therapy with severe immunodeficiency (including in the clinical picture of HIV infection) and in patients who underwent bone marrow transplantation;
• prevention of cytomegalovirus infection after bone marrow transplantation.
• for topical application in ophthalmology: keratitis and other eye injuries caused by the Herpes simplex virus;
• for external use: skin infections caused by viruses Herpes simplex and Varicella zoster.

Forms of release

Tablets 200 mg.

Cream (sometimes mistakenly referred to as ointment) for external use of 5%.

Instructions for use and dosing regimen

Inside adults and children older than 2 years - 200-400 mg 3-5 times a day, if necessary - 20 mg per 1 kg of body weight (up to 800 mg per reception) 4 times a day. Children under 2 years of age are given a dose equal to half the dose for adults. Duration of treatment - 5-10 days. In case of renal failure, correction of the dosing regimen is recommended.

Locally and externally apply 5 times a day. The dose and duration of treatment depend on the indications and the dosage form used.

Side effect

Ingestion:

• nausea, vomiting;
• diarrhea;
• abdominal pain;
• skin rash;
• headache, dizziness;
• increased fatigue;
• decreased concentration of attention;
• hallucinations;
• drowsiness or insomnia;
• fever;
• hair loss;
• transient increase in the concentration in the blood of bilirubin, urea, creatinine, activity of hepatic enzymes;
• transient lymphocytopenia, erythropenia, and leukopenia.

For local and external use:

• burning sensation in the place of application;
• skin rash;
• dry skin, peeling, itching;
• erythema (redness on the skin);
• superficial point keratitis (inflammation of the cornea);
• blepharitis (inflammation of the ciliary eyelid);
• conjunctivitis (inflammation of the eye mucosa).

Contraindications

• increased sensitivity to acyclovir and valacyclovir;
• at intravenous introduction - a lactemia (thoracal feeding).

Application in pregnancy and lactation

The use of Vivorax during pregnancy is possible in cases where the intended use for the mother exceeds the potential risk to the fetus.

Intravenous use of acyclovir during the lactation period is contraindicated (excreted in breast milk).

In experimental animal studies, it has been shown that acyclovir penetrates the placental barrier.

Use in children

Inside children over 2 years - 200-400 mg 3-5 times a day, if necessary - 20 mg per 1 kg of body weight (up to 800 mg per reception) 4 times a day. Children under 2 years of age are given a dose equal to half the dose for adults. Duration of treatment - 5-10 days.

Application in elderly patients

Treatment of elderly patients should be carried out with a sufficient increase in water load and under the supervision of a physician, since in this category of patients the half-life of acyclovir increases.

special instructions

It is not recommended for use in severe renal dysfunction.

It should be borne in mind that when Vivorax is used, acute renal failure may develop due to the formation of a precipitate from acyclovir crystals, which is particularly likely with rapid intravenous administration, simultaneous use of nephrotoxic drugs, in patients with impaired renal function and under inadequate water load.

When using acyclovir, it is necessary to monitor the kidney function (determining the level of urea Nitrogen in the blood and creatinine in the blood plasma).

In the treatment of genital herpes, sexual intercourse should be avoided or condoms used,the use of acyclovir does not prevent the transmission of the virus to partners.

Vivorax in the form of medicinal forms for external use should not be applied to the mucous membranes of the oral cavity, eyes, vagina.

Drug Interactions

With the simultaneous use of probenecid reduces the tubular secretion of acyclovir and thereby increases the concentration in the blood plasma and the half-life of acyclovir.

When used simultaneously with mycophenolate, mycophenolate increases the pharmacokinetic parameter (AUC), which characterizes the total concentration and acyclovir, and the inactive metabolite of mycophenolate mofetil in the blood plasma during the entire observation time.

With the simultaneous use of acyclovir with nephrotoxic drugs, the risk of developing nephrotoxic action increases (especially in patients with impaired renal function).

When mixing solutions, it is necessary to take into account the alkaline reaction of acyclovir for intravenous administration (pH 11).

Analogues of the drug Vivorax

Structural analogs for the active substance:

• Acigerpine;
• Acyclovir;
• Acyclovir tablets;
• Acyclostad;
• Virolex;
• Gervirax;
• Gerpevir;
• Gerperax;
• Herpes;
• Zovirax;
• Lysavir;
• The Medovar;
• Provirsan;
• Supperan;
• Cyclovax;
• Cyclovir;
• Cycloviral;
• Cytivir.

Analogues for the pharmacological group (antiviral agents):

• Avonex;
• Aktaviron;
• Actipol;
• Aldara;
• Alpisarin;
• Algeron;
• Altevir;
• Alfaron;
• Alfaferon;
• Amiksin;
• AnviMax;
• Arbidol;
• Arviron;
• Acyclovir;
• Acyclostad;
• Aeros;
• Bonaphoton;
• Vairova;
• Valaciclovir;
• Valcite;
• Vectavir;
• Virazole;
• Viru-Merz is a gray;
• Viferon;
• Wallferon;
• Genferon;
• Herpferon;
• Hyaferon;
• Devirs;
• Zovirax;
• Ingavirin;
• Interferal;
• Interferon leukocyte human;
• Infagel;
• Inferon;
• Influucine;
• Kagocel;
• Lavomax;
• Lysavir;
• The Medovar;
• Midantan;
• Neovir;
• Normomed;
• Oxolin;
• Panavir;
• Poludan;
• Remantadine;
• Ribavirin;
• Ronbetal;
• Sowaldi;
• Supperan;
• Tamiflu;
• Famciclovir;
• Cyclovax;
• Cyclovir;
• Elgravir;
• Erazaban.

A doctor's opinion of a dermatologist

The drug Vivorax in tablets and cream, I often use in my work. A good effect of the drug is given in the treatment of patients with shingles. One condition is that the patient should not only apply cream on the skin 5 times a day, but also conscientiously take the pills for at least 5-7 days, while observing a diet that excludes smoked products, spices, marinades, and alcohol.Eruptions quickly begin to dry up and by the end of treatment there are only single crusts on the skin. If the rashes are extensive, the general condition of the patient suffers, the course of treatment with Vivorax can last 10 days.

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