Orthoflex - instructions for use, analogs, reviews and release forms (ointment 2%) of the drug for the treatment of rheumatoid arthritis, gout, osteochondrosis, ankylosing spondylitis, arthrosis, bruises and sprains in adults, children and pregnancy

In this article, you can read the instructions for using the drug Orthoflex. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Orthoflex in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues Orthoflex in the presence of existing structural analogs.Use for the treatment of rheumatoid arthritis, gout, osteochondrosis, ankylosing spondylitis, arthrosis, bruises and sprains in adults, children, as well as during pregnancy and lactation.

Orthoflex - non-steroidal anti-inflammatory drug (NSAID), a derivative of phenylacetic acid. Has a pronounced anti-inflammatory, analgesic and moderate antipyretic effect.

The mechanism of action is associated with inhibition of cyclooxygenase (COX) activity, the main enzyme of arachidonic acid metabolism, which is a precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever. The analgesic effect is due to two mechanisms: peripheral (indirectly, through suppression of prostaglandin synthesis) and central (by inhibiting the synthesis of prostaglandins in the central and peripheral nervous system). Inhibits the synthesis of proteoglycan in the cartilage.

When rheumatic diseases reduces pain in joints at rest and during movement, as well as morning stiffness and swelling of the joints, contributes to an increase in the volume of movements. Reduces post-traumatic and post-operative pain, as well as inflammatory edema.

Composition

Diclofenac sodium + auxiliary substances.

Pharmacokinetics

After oral administration, it is absorbed (absorbed) from the gastrointestinal tract (GIT). Eating slows the rate of absorption. About half of the active substance is metabolized by the "first pass" through the liver. With rectal administration, absorption is slower. The time to reach the maximum concentration in the plasma after ingestion is 2-4 hours, depending on the dosage form used, after rectal administration - 1 hour, and after intramuscular injection - 20 minutes. Does not accumulate in the body. Binding to plasma proteins is 99.7% (mainly with albumin). It penetrates into the synovial fluid, where the maximum concentration of the drug substance is reached 2-4 hours later than in the plasma. It is metabolized to a great extent with the formation of several metabolites, among which two are pharmacologically active, but to a lesser extent than diclofenac. Approximately 60% of the dose is excreted as metabolites by the kidneys, less than 1% - with urine unchanged, the rest - in the form of metabolites with bile.

Indications

• osteoarthritis (arthritis);
• rheumatoid arthritis;
• ankylosing spondylitis (inflammation of the joints of the spine);
• gout;
• osteochondrosis (dystrophic changes in articular cartilage);
• osteoarthritis (arthrosis);
• periarthropathies (pain and limitation of joint movements);
• post-traumatic pains and inflammation of soft tissues and musculoskeletal system (sprains, bruises);
• pain in the spine;
• neuralgia (pain along the nerves);
• myalgia (pain in the muscles);
• arthralgia (joint pain).

Forms of release

Ointment for external use 2%.

Other dosage forms, whether tablets, drops in the ears or powder, at the time of publication of the drug in the Directory did not exist.

Instructions for use and dosing regimen

Externally, adults and children over 12 years of age are used depending on the area of ​​the painful area in a dose of 2-4 g (by volume comparable to the size of a large cherry) 3-4 times a day. The ointment is applied to the affected area with a thin layer and rubbed into the skin.

Children from 6 to 12 years should not be used more than 2 times a day, a single dose of the drug - up to 2 g.

The duration of treatment depends on the indications and the effect observed. Duration of treatment - no more than 14 days, prolongation of treatment is possible after consultation with a doctor.

Side effect

• itching;
• burning;
• redness of the skin;
• rash on the skin.

With prolonged use and / or application of the ointment on extensive areas of the body surface, systemic side effects are possible due to the resorptive (after absorption into the blood) action of diclofenac, namely:

• nausea;
• dizziness;
• headache;
• insomnia;
• feeling tired;
• irritability.

Contraindications

• increased sensitivity to diclofenac or excipients included in the composition of the ointment;
• hypersensitivity to other NSAIDs.

Application in pregnancy and lactation

Use of ointment Orthoflex during pregnancy and lactation is possible in cases where the intended benefit to the mother exceeds the potential risk to the fetus or newborn.

Use in children

It is not recommended for use in children under the age of 6 years.

Application in elderly patients

With extreme caution apply Orthoflex on large areas of the body in elderly patients.

special instructions

At the instructions in the anamnesis for allergic reactions to Diclofenac and other NSAIDs it is advisable not to use Orthoflex ointment.

Should be used only on intact skin areas.

Avoid contact with eyes and mucous membranes.

Drug Interactions

With simultaneous use with other NSAIDs, an increased risk of side effects may occur.

Analogues of the drug Orthoflex

Structural analogs for the active substance:

• Argett;
• Artrex;
• Beliefed;
• Voltaren;
• Diklak;
• Diklo-F;
• Diklobene;
• Dicluberl;
• Diqlovit;
• Diklogen;
• Diclomax;
• Diclomelan;
• Diclonac;
• Diclonat P;
• Dicloran;
• Diclorium;
• Diclofen;
• Diclofenac;
• Diclofenaclong;
• Diclofenacol;
• Diphene;
• Dorosan;
• Naklof;
• Naklofen;
• Orthophene;
• Orthofer;
• Penceid;
• Rapent;
• Revmavek;
• Redwood retard;
• Remetan;
• Sanfinak;
• Tabuk-Di;
• Feloran.

Analogues for the pharmacological group (NSAIDs - derivatives of acetic acid):

• Adolor;
• Alental;
• Argett;
• Artrex;
• Asinak;
• Aceclofenac;
• Aertal;
• Vatorlak;
• Beliefed;
• Voltaren;
• Diklak;
• Diklobene;
• Diqlovit;
• Diclomax;
• Diclonac;
• Dicloran;
• Diclofen;
• Diclofenac;
• Diclofenacol;
• Diphene;
• Dolak;
• Dolomin;
• Dorosan;
• Indomethacin;
• Indotard;
• Indocide;
• Cetadrope;
• Ketalgin;
• Ketanov;
• Ketokam;
• Ketolac;
• Ketorolac;
• Ketorol;
• Metindole;
• Naisylate;
• Naklof;
• Naklofen;
• Nevanac;
• Norobedolac;
• Orthophene;
• Orthofer;
• Penceid;
• Rantudil;
• Rapent;
• Revmavek;
• Remetan;
• Sanfinak;
• Tabuk-Di;
• Thoradol;
• Torolac;
• Feloran;
• Elderin.

Response of a rheumatologist

I prescribe Ortoflex ointment to patients with joint pain, both for the first time seeking help, and for those who have long suffered from gout or rheumatoid arthritis. Patients already after the first day of using the ointment note its good analgesic effect. In addition, patients say that the ointment is consumed very sparingly. If you smear 2-3 times a day, one large joint, for example, the knee, then a tube of ointment (30 g) lasts almost a week. Adverse reactions to this drug in the form of skin rashes, itching or burning of the skin in my practice was not one of the patients. Only once the patient with inflammation of the elbow joint smeared the skin over him with two ointments containing diclofenac. And on the same day she addressed me with complaints about the bright reddening of the skin in the area of ​​the elbow. I advised her to take a shower, to wash off the remnants of ointments well and continue to use only one Orthoflex. After this, the patient no longer had such problems.

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