Artoxan - instructions for use, analogs, testimonials and release forms (injections in ampoules for injections of 20 mg) drugs for the treatment of pain in the joints and muscles in arthritis, arthrosis, neuralgia in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Artoxane. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Arthoksan in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Arthoksan in the presence of existing structural analogs. Use for the treatment of pain in the joints and muscles in arthritis, neuralgia, myalgia in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Artoxane - a non-steroidal anti-inflammatory drug (NSAID) of the class of oxicams. Has a powerful analgesic and anti-inflammatory effect, antipyretic effect is less pronounced. The mechanism of action is based on inhibition of the activity of isoenzymes COX-1 and COX-2, as a result of which the synthesis of prostaglandins in the inflammatory focus and other body tissues is reduced. In addition, tenoxicam (the active substance of the drug Artoxan) reduces the accumulation of leukocytes in the focus of inflammation. A distinctive feature of tenoxicam is a long duration of action.

Composition

Tenoxicam + auxiliary substances.

Pharmacokinetics

Absorption is fast and complete. Bioavailability is 100%. The distinctive ability of tenoxicam is a long duration of action and a long half-life. The drug is 99% bound to blood plasma proteins. Tenoxicam penetrates well into the synovial fluid. Easily penetrates through the histohematological barriers. Metabolised in the liver by hydroxylation to form 5-hydroxypyridyl. 1/3 is secreted through the intestine with bile, 2/3 is excreted by the kidneys in the form of inactive metabolites.

Indications

• rheumatoid arthritis;
• arthrosis;
• myalgia;
• ankylosing spondylitis;
• articular syndrome with exacerbation of gout;
• bursitis;
• tenosynovitis;
• pain with injuries, burns;
• pain syndrome (weak and medium intensity): arthralgia, myalgia, neuralgia, migraine, dental and headache, algodismenorea;
• radicular syndrome.

Forms of release

Lyophilizate for the preparation of a solution for intravenous and intramuscular administration of 20 mg (injections in ampoules for injection).

Other dosage forms, be it tablets or capsules, did not exist in the Directory at the time of publication of the drug.

Instructions for use and dosage

Intramuscular injections are done deeply.

The duration of intravenous administration should not be less than 15 seconds.

Intramuscular or intravenous administration is used for short-term (1-2 days) treatment at a dose of 20 mg per day. If necessary, further therapy is transferred to oral dosage forms of tenoxicam.

The injection solution is prepared immediately before use by dissolving the contents of the vial with the supplied solvent. After preparation, the needle is replaced.

Side effect

• erosive and ulcerative lesions of the gastrointestinal tract;
• diarrhea;
• stomach ache;
• nausea, vomiting;
• flatulence;
• gastritis;
• esophagitis;
• bleeding from erosions, ulcers, as well as rectal and hemorrhoidal hemorrhages, which is a consequence of inhibition of thromboxane A2 synthesis;
• increased transaminase activity in the blood;
• a decrease in the level of hemoglobin, not associated with bleeding;
• anemia, thrombocytopenia, leukopenia, eosinophilia;
• hyperglycemia;
• reversible increase in urea nitrogen and creatinine in blood plasma;
• headache;
• dizziness;
• tremor;
• excitation;
• insomnia or drowsiness;
• irritation and swelling of the eyelids (with normal results of ophthalmoscopy);
• paresthesia;
• Lyell's syndrome;
• Stevens-Johnson syndrome;
• hives;
• itching;
• alopecia;
• photosensitization;
• changes in nails;
• netrombotsitopenicheskaya purpura.

Contraindications

• hypersensitivity to the active substance or auxiliary components of the drug (there is a possibility of cross-sensitivity to acetylsalicylic acid (ASA), ibuprofen and other NSAIDs);
• erosive and ulcerative lesions of the stomach and duodenum in the stage of exacerbation;
• gastrointestinal bleeding (including in the anamnesis);
• inflammatory bowel disease: Crohn's disease or ulcerative colitis in the acute stage;
• severe renal failure (creatinine clearance less than 30 ml / min);
• progressive kidney disease;
• severe hepatic impairment;
• complete or incomplete combination of bronchial asthma, recurrent nasal polyposis and paranasal sinuses and intolerance to ASA or other NSAIDs (including and in history);
• established diagnosis of blood coagulation system diseases;
• Decompensated heart failure;
• therapy of perioperative pain during coronary artery bypass grafting;
• pregnancy;
• the period of breastfeeding;
• age to 18 years.

Application in pregnancy and lactation

Artoxane is contraindicated in pregnancy and lactation.

Due to the use of tenoxicam during pregnancy, lengthening of pregnancy, delay in labor and weak labor activity (as a result of a decrease in the synthesis of prostaglandins stimulating the rhythmic contractile activity of the myometrium) is possible.

Use in children

Contraindicated in children and adolescents under the age of 18 years.

special instructions

When Arthoxan is used, the function of the digestive tract should be carefully monitored. If the first signs of ulcerogenesis or gastrointestinal bleeding are discovered, tenoxicam should be immediately withdrawn.

Use with caution in patients with impaired renal function (including those caused by diabetes mellitus). Prostaglandins synthesized in the kidneys regulate the volumetric flow in the renal parenchyma. If the synthesis of prostaglandins under the influence of tenoxicam, development of a decrease in renal blood flow is possible, leading to the phenomena of renal failure, as well as to interstitial nephritis, glomerulonephritis, papillary necrosis and nephrotic syndrome. Especially caution should be used tenoxicam on the background of treatment with diuretics or potentially nephrotoxic drugs.

For renal failure, patients with QC greater than 25 ml / min require careful monitoring of the physician without correction of the dosing regimen. Clinical data on the use of tenoxicam in patients with SC less than 25 ml / min are limited.

Use with caution in patients with impaired hepatic function. If against the background of the use of tenoxicam there is an excessive increase in the level of transaminases, which persists during therapy, then tenoxicam should be discontinued.

Artoxane is capable of retaining potassium, sodium, and water ions. In this regard, tenoxicum can worsen the course of hypertension or heart failure.

Artoxane reduces platelet aggregation and increases bleeding time, which should be borne in mind in upcoming surgical interventions.

It is not recommended to use Artoxane in combination with salicylates.

Drug Interactions

Tenoxicam has a high degree of binding to albumin and can, like all NSAIDs, enhance the anticoagulant effect of Warfarin and other anticoagulants. It is recommended to monitor blood levels when combined with anticoagulants and hypoglycemic drugs for oral administration, especially at the initial stages of use of the drug Artoxane.

There was no possible interaction with digoxin.

As with the application of other NSAIDs, it is recommended to use the drug with caution at the same time as cyclosporine in connection with an increased risk of developing nephrotoxicity.

Joint use with quinolones may increase the risk of seizures.

Salicylates can displace tenoxicam from bonding with albumin and, accordingly, increase the clearance of the drug.It is necessary to avoid the simultaneous use of salicylates or two or more NSAIDs (increased risk of complications from the gastrointestinal tract).

There is evidence that NSAIDs reduce the excretion of lithium. In this regard, patients receiving lithium therapy should more often monitor the concentration of lithium in the blood.

NSAIDs can cause sodium, potassium and liquid retention in the body, disrupting the action of natriuretic diuretics. This should be remembered when combined with such diuretics in patients with CHF and hypertension.

With caution, it is recommended to use NSAIDs in conjunction with methotrexate, NSAIDs reduce the excretion of Methotrexate and may increase its toxicity.

NSAIDs should not be used within 8-12 hours after application of mifepristone, because can reduce its effect.

It is necessary to take into account the increased risk of developing gastrointestinal bleeding when combined with corticosteroids.

Reduces the effectiveness of uricosuric medicines, enhances the effect of anticoagulants, fibrinolytics, side effects of mineralocorticosteroids and glucocorticosteroids (GCS), estrogens; reduces the effectiveness of antihypertensive drugs and diuretics.

Inducers of microsomal oxidation in the liver (phenytoin, ethanol (alcohol), barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites.

Joint use with antiplatelet agents and SSRIs increases the risk of developing gastrointestinal bleeding.

Cardiac glycosides when taken together with NSAIDs can increase heart failure, reduce GFR, and increase the plasma level of cardiac glycosides.

There was no interaction with the use of tenoxicam with cimetidine.

There was no clinically significant interaction in the treatment with tenoxicam and penicillamine or parenteral gold.

Increased risk of nephrotoxicity in the combined use of NSAIDs with tacrolimus.

The risk of hematological toxicity increases with the use of NSAIDs with zidovudine.

Analogues of the drug Artoxane

Structural analogs for the active substance:

• Texared;
• Tenikam;
• Tenoktil;
• Tilcotyl;
• Tobitil.

Analogues for the pharmacological group (NSAIDs from the group of oxycam):

• Amelotex;
• Arthrosan;
• Bixicam;
• Genitron;
• Zornika;
• Kalmopyrene;
• Xsefokam;
• Lem;
• Liberalum;
• Lornoxicam;
• Matarin;
• Matarin plus;
• Medsikam;
• Melbeck;
• Melbek forte;
• Melokvitis;
• Meloksam;
• Meloksikam;
• Meloks;
• Meloflam;
• Meloflex;
• Mesipol;
• Mixol;
• Mirlocks;
• Movalis;
• Movasin;
• Movix;
• Oxycamox;
• Pirokam;
• Piroxicam;
• Piroximeter;
• Revmadore;
• Remoxicam;
• Sanik;
• The Texman;
• Texared;
• Tenikam;
• Tenoktil;
• Teraflex Hondrokrem Forte;
• Tilcotyl;
• Tobitil;
• Feldoral;
• Velden;
• Finalal;
• Flexibon;
• Forte chondroxide;
• Hotemin;
• Exen Sanovel.

Similar medicines:

Other medicines: