Neupilept - instructions for use, reviews, analogs and form of release (solution for ingestion 100 mg, injections in ampoules for injections) drugs nootropics for the treatment of the consequences of stroke, head trauma in adults, children and pregnancy. Composition
In this article, you can read the instructions for using the drug Neupilept. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Neupileth in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Neupilept analogues in the presence of existing structural analogues.Use to treat the effects of stroke, head injuries in adults, children, as well as during pregnancy and lactation. Composition of the preparation.
Neupilept - Nootropic preparation. Citicoline (the active substance of the drug Neupilept) is a natural endogenous compound, which is an intermediate metabolite in the synthesis of phosphatidylcholine, one of the basic structural components of the cell membrane.
It has a wide spectrum of action - it promotes the restoration of damaged cell membranes, inhibits the effect of phospholipases, prevents excessive formation of free radicals, and also prevents the death of cells, affecting the mechanisms of apoptosis. In an acute period of stroke, citicoline reduces the amount of damage to the brain tissue, improves cholinergic transmission. With craniocerebral trauma reduces the duration of post-traumatic coma and the severity of neurologic symptoms, besides, it helps to reduce the duration of the recovery period.
With chronic hypoxia of the brain, citicoline is effective in treating cognitive disorders such as memory impairment, lack of initiative,The emergence of daily activities and self-service. Increases the level of attention and consciousness, and also reduces the manifestation of amnesia.
Neupilept is effective in the treatment of sensory and motor neurologic disorders of degenerative and vascular etiology.
Composition
Citicoline sodium + excipients.
Pharmacokinetics
Neupilept is well absorbed when taken orally. Absorption after oral administration is almost complete, bioavailability is almost the same as after intravenous administration. After taking the drug, the concentration of choline in the blood plasma increases significantly. Citicoline is largely distributed in the structures of the brain, with the rapid introduction of the choline fraction into structural phospholipids and cytidine fractions into cytidine nucleotides and nucleic acids. Having reached the brain, citicoline is embedded in the cellular, cytoplasmic and mitochondrial membranes, taking part in the construction of the phospholipid fraction. Citicoline is metabolized in the intestine and liver with the formation of choline and cytidine. Only 15% of the administered dose of citicoline is excreted from the human body: less than 3% - by the kidneys and about 12% - with exhaled CO2.In the excretion of the drug with urine, two phases are distinguished: the first phase is about 36 hours, in which the elimination rate decreases rapidly, and the second phase, in which the elimination rate decreases much more slowly. The same is observed in exhaled CO2, the elimination rate decreases rapidly after about 15 hours, later it decreases much more slowly.
Indications
- acute period of ischemic stroke (as part of complex therapy);
- the recovery period of ischemic and hemorrhagic strokes;
- craniocerebral trauma (TBI), acute (as part of complex therapy) and the recovery period;
- Cognitive and behavioral disorders in degenerative and vascular diseases of the brain.
Forms of release
Solution for oral administration 100 mg.
Solution for intravenous and intramuscular injection 500 mg and 1000 mg (injections in ampoules for injection).
Other dosage forms, be it syrup, drops, tablets or capsules at the time of publication of the drug in the Directory are not registered.
Instructions for use and dosing regimen
Solution for oral administration
The drug is taken orally, during meals or between meals.
Before use, Neupilept can be diluted in a small amount of water (100-120 ml or 1/2 cup).
Acute period of ischemic stroke and craniocerebral trauma: 1000 mg (10 ml) is prescribed every 12 hours. Treatment duration is at least 6 weeks.
The recovery period of ischemic and hemorrhagic strokes, the recovery period of craniocerebral trauma, cognitive and behavioral disorders in degenerative and cerebrovascular diseases of the brain: appoint 500-2000 mg (5-20 ml) per day. The dose and duration of treatment are determined depending on the severity of the symptoms of the disease.
In the appointment of Neupilept to elderly patients, dose adjustment is not required.
Ampoules
Acute period of ischemic stroke and craniocerebral trauma (CCI): 1000 mg every 12 hours from the first day after diagnosis, duration of treatment is not less than 6 weeks. The maximum daily dose is 2000 mg.
The recovery period of ischemic and hemorrhagic strokes, the recovery period of TBI, cognitive and behavioral disorders in degenerative and cerebrovascular diseases of the brain: administered intravenously or intramuscularly at 500-2000 mg per day.Dose and duration of treatment - depending on the severity of the symptoms of the disease.
When prescribing Neupilept to elderly patients, dose adjustment is not required.
The drug should be used immediately after opening the ampoule.
Neupileptom enter intramuscularly, intravenously struino (slowly, for 3-5 minutes, depending on the prescribed dose) or drip (in the form of a dropper) (infusion rate - 40-60 drops per minute).
In / in the route of administration is more preferable than in / m. With the / m introduction, the repeated administration of the drug in the same place should be avoided.
Neupilept is compatible with all types of intravenous isotonic solutions and Dextrose solutions.
Side effect
- allergic reactions (rash, itching, anaphylactic shock);
- headache;
- dizziness;
- feeling of heat;
- tremor;
- nausea, vomiting;
- diarrhea;
- hallucinations;
- edema;
- dyspnea;
- insomnia;
- excitation;
- decreased appetite;
- numbness in the paralyzed limbs;
- change in hepatic enzyme activity;
- short-term change in blood pressure.
Contraindications
- hypersensitivity to any of the components of the drug;
- should not be prescribed to patients with severe vagotonia (high tone of the parasympathetic part of the autonomic nervous system);
- due to the lack of sufficient clinical data, is not recommended for use in children under 18 years of age.
Application in pregnancy and lactation
There is insufficient data on the use of neupileth in pregnant women. Although no adverse effects have been identified in animal studies, citicoline is prescribed during pregnancy only when the expected benefit to the mother exceeds the potential risk to the fetus.
When using Neupilept during lactation, women should stop breastfeeding, as there is no data on the excretion of citicoline with breast milk.
Use in children
The use of the drug for children and adolescents under the age of 18 is contraindicated.
Application in elderly patients
When prescribing the drug for elderly patients, dose adjustment is not required.
special instructions
Intravenously run Neupilept slowly (3-5 minutes depending on the dose). With IV injection, the infusion rate should be 40-60 drops per minute.
With persistent intracranial hemorrhage, it is recommended not to exceed the dose of the drug Neupilept 1000 mg per day, the drug is injected intravenously at a rate of 30 drops per minute.
In the cold, a small amount of crystals may form in the syrup due to the temporary partial crystallization of the preservative. With further storage under the recommended conditions, the crystals dissolve within a few months. The presence of crystals does not affect the quality of the drug.
Influence on ability to drive vehicles, mechanisms
During the use of the drug, caution should be exercised in managing the transport and in dealing with other potentially hazardous activities requiring increased concentration of attention and speed of psychomotor reactions.
Drug Interactions
Citicoline increases the effects of levodopa.
Do not use simultaneously with medicines containing meclofenoxate.
Analogues of the drug Neupilept
Structural analogs for the active substance:
- Quinel;
- Lyra;
- Proneiro;
- Recognan;
- Ceraxon;
- Citicolin sodium.
Analogues for the pharmacological group (nootropics):
- Aminalon;
- Anvifen;
- Astrox;
- Bilobil;
- Vinpotropil;
- Gamalon;
- Gliatilin;
- Glycine;
- Glycine forte;
- Gopantam;
- Delecite;
- Divaza;
- Idebenon;
- Combbitropyl;
- Cortexin;
- Cortexin for children;
- Lucetsam;
- Meclofenoxate hydrochloride;
- Mexiprim;
- Mexicin;
- Memotropized;
- Minisem;
- Neurox;
- Neuromet;
- Noben;
- Hoenopt;
- Nootropil;
- Noophen;
- Noocetam;
- Omaron;
- Pantogam;
- Pantokaltsin;
- Pikamilon;
- Piraben;
- Piracesine;
- Piracetam;
- Semax;
- Stamine;
- Tenoten;
- Tenoten for children;
- Thiocetam;
- Fezam;
- Fenibut;
- Phenotropil;
- Choline alphoscerate;
- Holilitil;
- Cerebrosolate;
- Cerebrolysin;
- Cerepro;
- Cereton;
- Cerutil;
- Energol;
- Encephabol;
- The escotrope.
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