Kalmireks - instructions for use, analogs, reviews and release forms (injections in ampoules for injections, tablets of 50 mg and 150 mg tabs) of a drug for the treatment of muscle pain in arthrosis, lumbulgia in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Kalmireks. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Kalmireks in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Kalmirex in the presence of existing structural analogs.Use for the treatment of pain in arthrosis, lumbalia, hypertension and muscle spasm in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Kalmireks - Muscle relaxant of central action. Has a membrane-stabilizing, local anesthetic effect, inhibits the conduction of nerve impulses in primary afferent fibers and motor neurons, which results in blocking of spinal mono- and polysynaptic reflexes. Probably mediates the blocking of mediator excretion by inhibiting the entry of calcium ions into the synapses. It stops the excitation on the reticulospinal path in the brainstem. Regardless of the effect on the central nervous system increases peripheral blood flow. In the development of this effect, the weak antispasmodic and anti-adrenergic effect of Tolperisone (the active ingredient of the Kalmirex preparation) may play a role.

Lidocaine hydrochloride has a local anesthetic effect and does not have a systemic effect when dosed according to the instructions.

Composition

Tolperisone + auxiliary substances (Kalmirex tabs).

Tolperisone hydrochloride + Lidocaine hydrochloride + excipients.

Pharmacokinetics

Tolperisone hydrochloride

Tolperisone is extensively metabolized in the liver and kidneys. Excreted in the urine almost exclusively (more than 99%) in the form of metabolites. Pharmacological activity of metabolites is unknown.

Lidocaine hydrochloride

Absorption is complete (the rate of absorption depends on the site of administration and the dose). Binding to plasma proteins - 50-80%. Rapidly distributed in tissues and organs. It penetrates the blood-brain barrier (GEB) and placental barrier, penetrates into breast milk (40% concentration in the mother plasma). Metabolised in the liver (by 90-95%) with the participation of microsomal enzymes by dealkylation of the amino group and breaking of the amide bond with the formation of active metabolites. It is excreted with bile (part of the dose is reabsorbed in the digestive tract) and kidneys (up to 10% unchanged).

Indications

• hypertension and spasm of the striated musculature, arising from organic diseases of the central nervous system (including the defeat of pyramidal tracts, multiple sclerosis, stroke, myelopathy, encephalomyelitis), musculoskeletal system (including spondylosis, spondyloarthrosis, cervical and lumbar syndromes, arthrosis of large joints);
• Restorative treatment after orthopedic and traumatological operations.

As part of complex therapy:

• with obliterating diseases of blood vessels (obliterating atherosclerosis, diabetic angiopathy, obliterating thromboangiitis, Raynaud's disease, diffuse scleroderma);
• at the diseases arising on the basis of a disorder of innervation of blood vessels (acrocyanosis, intermittent angioneurotic dysbasia).

Forms of release

Solution for intravenous and intramuscular injection (injections in ampoules for injection).

Tablets coated with 50 mg and 150 mg (Kalmirex tabs).

Instructions for use and dosage

Ampoules

Adults drug is prescribed daily intramuscularly at 100 mg twice a day or intravenously at 100 mg once a day.

Tablets tabs

Inside, after eating, without chewing, with a small amount of water.

Starting with 50 mg 2-3 times a day, gradually increasing the dose to 150 mg 2-3 times a day.

Side effect

• anemia;
• lymphadenopathy;
• hypersensitivity reactions;
• anaphylactic reactions;
• anaphylactic shock;
• anorexia;
• polydipsia;
• insomnia;
• sleep disorders;
• loss of activity;
• depression;
• headache;
• dizziness;
• drowsiness;
• attention deficit disorder;
• tremor;
• convulsions;
• loss of sensitivity;
• sensitivity disorders;
• lethargy;
• visual impairment;
• tinnitus;
• vertigo;
• arterial hypotension;
• angina pectoris;
• tachycardia;
• cardiopalmus;
• bradycardia;
• flushes of blood;
• dyspnea;
• nose bleed;
• rapid breathing;
• gastrointestinal discomfort;
• diarrhea, constipation;
• dry mouth, indigestion;
• nausea, vomiting;
• pain in epigastrium;
• flatulence;
• impaired liver function;
• allergic dermatitis;
• sweating;
• itching;
• hives;
• skin rash;
• muscle weakness;
• myalgia;
• pain in the limbs;
• discomfort in the extremities;
• osteopenia;
• enuresis;
• proteinuria;
• redness of the injection site;
• asthenia (weakness);
• malaise, fatigue;
• feeling of intoxication;
• sensation of heat;
• irritability;
• thirst;
• a feeling of discomfort in the chest;
• increased bilirubin concentration;
• violation of functional liver samples;
• decrease in the number of platelets;
• increase in the number of leukocytes;
• increase in the level of creatinine.

Contraindications

• severe myasthenia gravis;
• pregnancy;
• lactation period;
• children and adolescents under 18;
• Hypersensitivity to the components of the drug, incl. to lidocaine.

Application in pregnancy and lactation

Contraindicated use of the drug Kalmireks during pregnancy and lactation.

Use in children

Contraindicated use of the drug in children and adolescents under 18 years.

special instructions

Use strictly according to the doctor's prescription to avoid complications.

Impact on the ability to drive vehicles and manage mechanisms

Care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased attention and speed of psychomotor reactions.

Drug Interactions

There is no data on interactions with drugs that limit the use of Kalmirex.

Although tolperisone has an effect on the central nervous system, the drug does not cause sedation, so it can be used in combination with sedatives, hypnotics and preparations containing ethanol (alcohol).

Does not increase the effect of ethanol (alcohol) on the central nervous system.

Strengthens the action of non-steroidal anti-inflammatory drugs (NSAIDs), so with simultaneous use, you may need to reduce the dose of the latter.

Analogues of Kalmireks medicinal product

Structural analogs for the active substance:

• Kalmirex tabs;
• Midokalm;
• Tolizor;
• Tolperisone.

Analogues for the pharmacological group (drugs that affect neuromuscular transmission):

• Baclosan;
• Baclofen;
• Botox;
• Botulaks;
• Dysport;
• Kalmirex tabs;
• Xeomin;
• Lantox;
• Liorasal Intrathecal;
• Miolastane;
• Sirdalud;
• Tisaloud;
• Tizanidine;
• Tizanil.

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