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Enzistal - instructions for use, analogs, reviews and release forms (tablets in a package of 4, 6, 20, 80 and 100 pieces, P with pancreatin) of a drug for the treatment of dyspepsia, pancreatitis in adults, children and pregnancy. Composition

Enzistal - instructions for use, analogs, reviews and release forms (tablets in a package of 4, 6, 20, 80 and 100 pieces, P with pancreatin) of a drug for the treatment of dyspepsia, pancreatitis in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Enzistal. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Enzistal in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Enzistal in the presence of existing structural analogues. Use to treat dyspepsia, pancreatitis and improve digestion of food in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

 

Enzistal - Combined drug, the effect of which is due to the components that make up its composition. It has a proteolytic, amylolytic and lipolytic effect. Has a protective coating that does not dissolve before entering the small intestine, which protects the enzymes from the destructive effect of gastric juice. Promotes fast and complete digestion of food, eliminates symptoms that result from digestive disorders (feeling of heaviness and overflow of the stomach, flatulence, lack of air, shortness of breath due to the accumulation of gases in the intestines, diarrhea). Improves the process of digestion of food in children; stimulates the release of its own enzymes of the pancreas, stomach and small intestine, as well as bile. Bile extract acts choleretically, promotes fat emulsification, increases lipase activity, improves absorption of fats and fat-soluble Vitamins A, E, K. Hemicellulase is an enzyme that promotes the breakdown of plant fiber.

 

Enzistal P is an enzyme agent. Contains pancreatic enzymes - amylase, lipase and proteases, which facilitate the digestion of carbohydrates, fats and proteins, which contributes to their fuller absorption in the small intestine.In diseases of the pancreas, it compensates for the lack of its exocrine function and improves the digestive process.

 

Composition

 

Pancreatin + auxiliary substances (Enzistal P).

 

Pancreatin (lipase, amylase, protease) + Bovine bile extract + Hemicellulase + auxiliary substances (Enzistal).

 

Indications

  • exocrine insufficiency of the pancreas, stomach, intestines, liver, gallbladder (chronic inflammatory-dystrophic diseases of these organs, condition after resection or irradiation);
  • flatulence;
  • diarrhea of ​​non-infectious genesis (functional diarrhea);
  • cystic fibrosis;
  • to improve the digestion of food in individuals with normal gastrointestinal function in the event of: inaccuracies in the diet (eating fatty foods, large amounts of food, irregular meals); with violations of the masticatory function (damage to the teeth and gums, during the period of getting used to the artificial jaw); sedentary lifestyle; prolonged immobilization;
  • preparation for X-ray examination and ultrasound of the abdominal cavity organs;
  • as an auxiliary drug for the early absorption of certain drugs (PASK, sulfonamides, antibiotics).

 

Forms of release

 

Tablets coated with an enteric coating in a package of 4, 6, 20, 80 or 100 pieces (Enzistal).

 

Tablets coated with an enteric coating in a package of 10, 20 or 80 pieces (Enzistal P).

 

Instructions for use and dosing regimen

 

Inside, 1 dragee (an enteric-coated tablet) 3 times a day during or immediately after meals. Swallowed whole, can not chew. If necessary, single dose is increased 2 times. Duration of treatment - from several days (with digestion disorders due to inaccuracies in nutrition) to several months and years (if necessary, permanent replacement therapy).

 

Before the X-ray examination and ultrasound - 2 dragees 2-3 times a day for 2-3 days before the study.

 

Side effect

  • allergic reactions (skin hyperemia, sneezing, lacrimation);
  • diarrhea;
  • nausea;
  • abdominal pain (including intestinal colic);
  • hyperuricemia, hyperuricosuria;
  • in children (when taken in large doses) - perianal irritation, irritation of the mucous membrane of the oral cavity.

 

Contraindications

  • hypersensitivity;
  • hyperbilirubinemia;
  • acute pancreatitis;
  • chronic pancreatitis (exacerbation);
  • hepatitis;
  • liver failure;
  • hepatic coma or precoma;
  • empyema of the gallbladder;
  • cholelithiasis;
  • mechanical jaundice;
  • intestinal obstruction.

 

Application in pregnancy and lactation

 

The safety of Pancreatin in pregnancy is not well understood. The use of Enzistal is possible in cases where the expected benefit to the mother exceeds the potential risk to the fetus.

 

In experimental studies, it has been established that pancreatin does not have a teratogenic effect.

 

Use in children

 

The application is possible according to the dosing regimen. With a high activity of lipase contained in pancreatin, the probability of constipation in children increases.

 

Use with caution in children under 3 years.

 

special instructions

 

It is not recommended to use Enzistal and Enzistal P in the phase of exacerbation of chronic pancreatitis.

 

In cystic fibrosis, the dose should be adequate to the number of enzymes that are needed to absorb fat, taking into account the quality and quantity of food consumed.

 

In cystic fibrosis is not suitable for the use of pancreatin at doses greater than 10 000 IU / kg per day (based on lipase) due to increased risk of strictures (fibrosing colonopathy) in ileocecal department and in the ascending colon.

 

With a high activity of lipase contained in pancreatin, the probability of constipation in children increases. Increase in the dose of pancreatin in this category of patients should be carried out gradually.

 

Disturbances from the digestive system can occur in patients with increased sensitivity to pancreatin, or in patients with meconium ileus or bowel resection in the anamnesis.

 

When appointing patients with suspected appendicitis, special care should be taken.

 

Drug Interactions

 

Reduces the bioavailability of iron preparations

 

Increases the absorption of PASC, sulfonamides, antibiotics.

 

Cimetidine enhances the effect of the drug.

 

With simultaneous use, it is theoretically possible to reduce the clinical efficacy of acarbose.

 

While the use of antacids containing calcium carbonate and / or magnesium hydroxide, may decrease the efficiency of pancreatin.

 

Analogues of the drug Enzistal

 

Structural analogs for the active substance:

  • Gastenorm forte;
  • Creon 10000;
  • Creon 25,000;
  • Creon 40000;
  • Creon Micro;
  • Mezim 20000;
  • Mezim forte;
  • Mezim forte 10000;
  • Mikrazim;
  • Pangrol 10000;
  • Pangrol 25,000;
  • PanziKam;
  • Panzim Forte;
  • Panzinorm 10,000;
  • Penzinorm forte 20 000;
  • Pancreatym;
  • Pancreatin;
  • Pancreatin forte;
  • Pancrelipase;
  • Pantcitrate;
  • Penzital;
  • Festal N;
  • Enzistal P;
  • Hermitage.

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