Faspik - instructions for use, analogs, reviews and release forms (tablets 400 mg, granules or powder for the preparation of a solution) for the treatment of pain and inflammation in arthritis, migraine, menstruation in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Faspik. There are reviews of visitors to the site - consumers of this anesthetic and anti-inflammatory medication, as well as opinions of physicians specialists on using Faspik in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Faspik in the presence of existing structural analogs.Use for the treatment of pain and inflammation in arthritis, arthrosis, migraine, menstruation in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Faspik non-steroidal anti-inflammatory drug (NSAID). Ibuprofen - an active substance of the preparation Faspik - is a derivative of propionic acid and has analgesic, antipyretic and anti-inflammatory effects due to the indiscriminate blockade of COX-1 and COX-2, as well as the inhibitory effect on the synthesis of prostaglandins.

Analgesic effect is most pronounced for inflammatory pains. The analgesic activity of the drug does not belong to the opioid type.

Like other NSAIDs, ibuprofen has antiaggregant activity.

Analgesic effect with the use of the preparation Faspik develops 10-45 minutes after its administration.

Composition

Ibuprofen + excipients.

Pharmacokinetics

After ingestion, the drug is well absorbed from the digestive tract. Binding to plasma proteins is about 99%. It is slowly distributed in the synovial fluid and is withdrawn from it more slowly than from the plasma.Ibuprofen is metabolized in the liver mainly by hydroxylation and carboxylation of the isobutyl group. Metabolites are pharmacologically inactive. Characterized by a two-phase kinetics of excretion. Up to 90% of the dose can be detected in the urine in the form of metabolites and their conjugates. Less than 1% is excreted unchanged in the urine and to a lesser extent - with bile.

Indications

• febrile syndrome of different genesis;
• pain syndrome of various etiologies (including sore throat, headache, migraine, toothache, neuralgia, post-operative pain, posttraumatic pain, primary algodismenorrhea);
• inflammatory and degenerative diseases of the joints and spine (including rheumatoid arthritis, ankylosing spondylitis).

The drug is intended for symptomatic therapy, reducing pain and inflammation at the time of use, the progression of the disease is not affected.

Forms of release

The tablets covered with a cover of 400 mg.

Granules for the preparation of solution for oral administration in bags of 400 mg (sometimes mistakenly referred to as powder).

Instructions for use and dosing regimen

Pills

The drug is taken orally.

Adults and children over 12 years of age, the drug is given in the form of tablets in an initial dose of 400 mg; if necessary, 400 mg every 4-6 hours. The maximum daily dose is 1200 mg. The tablet is washed down with a glass of water (200 ml). To reduce the risk of developing dyspeptic side effects, it is recommended to take the drug while eating.

The drug should not be taken more than 7 days or at higher doses. If it is necessary to take longer, or at higher doses, a doctor's consultation is required.

Granules

Adults with ankylosing spondylitis - 400-600 mg 3-4 times a day; with rheumatoid arthritis - 800 mg 3 times a day; at posttraumatic pains - 1.6-2.4 g per day in several doses; with algodismenorea - 400 mg 3-4 times a day; with pain syndrome - up to 1.2 grams per day in several receptions.

Children older than 12 years with juvenile rheumatoid arthritis - 30-40 mg / kg per day in divided doses 3-4 times a day; to reduce body temperature more than 39.2 degrees Celsius - 10 mg / kg per day, less than 39.2 degrees Celsius - 5 mg / kg per day; When used as an analgesic, depending on the strength of pain, such doses are prescribed. The maximum daily dose for children is 40 mg / kg of body weight.

The recommended daily intake for adults with the drug is 1.2 g (the contents of 6 packages of 200 mg, the contents of 3 packages of 400 mg, or the contents of 2 packets of 600 mg). Rheumatoid arthritis recommends the use of higher doses, but not more than 2.4 mg per day (the contents of 12 packages of 200 mg, the contents of 6 packages of 400 mg or the contents of 4 packets of 600 mg).

The contents of the package are dissolved in water (50-100 ml) and taken inside immediately after the preparation of the solution during or after a meal.

To overcome the morning stiffness in patients with arthritis, it is recommended to take the first dose of the drug immediately after awakening.

In patients with impaired renal, hepatic or cardiac function, the dose should be reduced.

The duration of treatment with febrile syndrome is no more than 3 days, with pain syndrome - no more than 5 days.

Side effect

• NSAID-gastropathy - abdominal pain, nausea, vomiting, heartburn, worsening of appetite, diarrhea, flatulence, constipation
• ulceration of the gastrointestinal mucosa (in some cases complicated by perforation and bleeding);
• irritation or dryness of the oral mucosa;
• pain in the mouth;
• ulceration of the gingival mucosa;
• aphthous stomatitis;
• pancreatitis;
• hepatitis;
• dyspnea;
• bronchospasm;
• hearing loss;
• ringing or noise in the ears;
• toxic damage of the optic nerve;
• blurred vision or double vision;
• scotoma;
• dryness and irritation of the eyes;
• edema of the conjunctiva and eyelids (allergic genesis);
• headache;
• dizziness;
• insomnia;
• anxiety;
• nervousness and irritability;
• psychomotor agitation;
• drowsiness;
• depression;
• confusion of consciousness;
• hallucinations;
• aseptic meningitis (more often in patients with autoimmune diseases);
• heart failure;
• tachycardia;
• increased blood pressure;
• acute renal insufficiency;
• allergic nephritis;
• nephrotic syndrome (edema);
• polyuria;
• cystitis;
• anemia (including hemolytic, aplastic), thrombocytopenia, thrombocytopenic purpura, agranulocytosis, leukopenia;
• increased bleeding time;
• decrease in serum glucose concentration;
• a decrease in hematocrit or hemoglobin;
• increased serum creatinine concentration;
• increased activity of hepatic transaminases;
• skin rash (usually erythematous or urticaria);
• itching;
• angioedema;
• anaphylactoid reactions;
• anaphylactic shock;
• bronchospasm;
• dyspnea;
• fever;
• multi-form exudative erythema (including Stevens-Johnson syndrome);
• toxic epidermal necrolysis (Lyell's syndrome);
• eosinophilia;
• allergic rhinitis.

With long-term use of the drug in high doses, the risk of ulceration of the gastrointestinal mucosa increases, bleeding (gastrointestinal, gingival, uterine, hemorrhoidal), visual impairment (color vision, scotoma, optic nerve damage).

Contraindications

• erosive and ulcerative diseases of the digestive tract (including gastric ulcer and duodenal ulcer in the phase of exacerbation, Crohn's disease, ulcerative colitis or NNC);
• "aspirin" asthma;
• hemophilia and other disorders of blood clotting (including hypocoagulation), hemorrhagic diathesis;
• bleeding of various etiologies;
• diseases of the optic nerve;
• pregnancy;
• lactation period;
• children's age till 12 years;
• hypersensitivity to the components of the drug;
• Hypersensitivity to acetylsalicylic acid or other NSAIDs in the anamnesis.

Application in pregnancy and lactation

The drug is contraindicated for use in pregnancy and lactation (breastfeeding).

The use of Faspik can adversely affect female fertility and is not recommended for women planning a pregnancy.

Use in children

Contraindicated in children under 12 years.

Application in elderly patients

With caution should be used in elderly patients.

special instructions

If there are signs of bleeding from the gastrointestinal tract, Faspik should be canceled.

Application Faspika can mask the objective and subjective symptoms of infection, so the drug should be administered with caution to patients with infectious diseases.

The occurrence of bronchospasm is possible in patients suffering from bronchial asthma or allergic reactions in the anamnesis or in the present.

Side effects can be reduced by using the drug in the lowest effective dose. With prolonged use of analgesics, there is a risk of developing analgesic nephropathy.

Patients who report visual impairment with Faspic therapy should stop treatment and undergo ophthalmologic examination.

Ibuprofen may increase the activity of hepatic enzymes.

During treatment, it is necessary to monitor the picture of peripheral blood and the functional state of the liver and kidneys.

When symptoms of gastropathy appear, careful monitoring including esophagogastroduodenoscopy, a blood test with determination of hemoglobin, hematocrit, analysis of feces for latent blood is shown.

To prevent the development of NSAID-gastropathy ibuprofen is recommended to be combined with preparations of prostaglandin E (misoprostol).

If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the test.

During the period of treatment, ethanol (alcohol) is not recommended.

The preparation contains sucrose (1 tablet - 16.7 mg, 1 packet of granules - 1.84 g), which should be taken into account if there is a corresponding hereditary intolerance to fructose, glucose-galactose malabsorption syndrome or isomaltase deficiency.

Impact on the ability to drive vehicles and manage mechanisms

Patients should refrain from all activities requiring increased attention and speed of psychomotor reactions.

Drug Interactions

It is possible to decrease the effectiveness of Furosemide and thiazide diuretics due to the delay of sodium associated with inhibiting the synthesis of prostaglandins in the kidneys.

Ibuprofen may enhance the effect of indirect anticoagulants, antiplatelet agents, fibrinolytic agents (increased risk of hemorrhagic complications).

With concomitant administration with acetylsalicylic acid, ibuprofen reduces its antiaggregant effect (possibly an increase in the incidence of acute coronary insufficiency in patients receiving small doses of Acetylsalicylic acid as an antiplatelet agent).

Ibuprofen may reduce the effectiveness of antihypertensive drugs (including slow calcium channel blockers and ACE inhibitors).

In the literature, single cases of an increase in plasma concentrations of digoxin, phenytoin and lithium with simultaneous administration of ibuprofen have been described. The agents blocking tubular secretion, reduce the excretion and increase the plasma concentration of ibuprofen.

Faspik, like other NSAIDs, should be used with caution in combination with acetylsalicylic acid or other NSAIDs. this increases the risk of adverse effects of the drug on the gastrointestinal tract.

Ibuprofen may increase the concentration of Methotrexate in the plasma.

Combined therapy with zidovudine and Faspik may increase the risk of hemarthrosis and hematoma in HIV-infected patients with hemophilia.

The combined use of Faspik and tacrolimus may increase the risk of developing nephrotoxic effects due to a violation of prostaglandin synthesis in the kidneys.

Ibuprofen enhances the hypoglycemic effect of oral hypoglycemic agents and insulin; it may be necessary to adjust the dose.

The ulcerogenic effect with bleeding is described with the combination of Faspik with colchicine, estrogens, ethanol (alcohol), glucocorticosteroids (GCS).

Antacids and colestyramine reduce the absorption of ibuprofen.

Caffeine enhances the analgesic effect of Faspic.

With the simultaneous use of Faspik with thrombolytic agents (alteplase, streptokinase, urokinase), the risk of bleeding increases.

Cefamandol, cefoperazone, cefotetan, valproic acid, plikamycin with simultaneous application with Faspik increase the frequency of hypoprothrombinemia.

Myelotoxic agents with simultaneous application intensify manifestations of hematotoxicity of Faspic.

Cyclosporine and gold preparations increase the effect of ibuprofen on the synthesis of prostaglandin in the kidneys, which is manifested by increased nephrotoxicity.

Ibuprofen increases the plasma concentration of cyclosporine and the likelihood of its hepatotoxic effects.

Inducers of microsomal oxidation (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites of ibuprofen, increasing the risk of developing severe hepatotoxic reactions.

Inhibitors of microsomal oxidation reduce the risk of hepatotoxic action of ibuprofen.

Analogues of the drug Faspik

Structural analogs for the active substance:

• Advance;
• Advil for children;
• ArthroCam;
• Bonifen;
• Brudol for children;
• Brufen;
• Brufen retard;
• Burana;
• Deblock;
• Children's Motrin;
• Dolgit;
• Ibuprom Sprint Caps;
• Ibuprofen;
• Ibuprofen for children;
• Ibusan;
• Ibutop gel;
• Ibufen;
• Iprene;
• MIG 200;
• MIG 400;
• MIG for children;
• MIL for babies;
• Maksikold for children;
• Nebolin caps;
• Next is Uno Express;
• Nurofen;
• Nurofen Rapid Forte;
• Nurofen UltraKap;
• Nurofen Express;
• Nurofen Express Neo;
• Nurofen Express forte;
• Nurofen for children;
• Nurofen fort;
• Pedee;
• Sedaling the Sprint;
• Solpaflex.

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