Karsil - instructions for use, reviews, analogs and forms of the release (pills or tablets 35 mg, capsules forte) of the drug for the treatment of cirrhosis and hepatitis in adults, children and pregnancy. Cholagogue action

In this article, you can read the instructions for using the drug Karsil. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Karsil in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Karsil in the presence of existing structural analogs. Use for the treatment of cirrhosis and hepatitis, choleretic effect in adults, children, as well as during pregnancy and lactation.

Karsil hepatoprotector. Contains a dry extract of the Milk thistle fruit (the equivalent of silymarin (active ingredient of the drug Karsil)), which is a mixture of 4 isomers of flavonolignanes: silybinin, iso-silibinin, silidianin and silicristin. The mechanism of action of the drug is not clear enough. It is known that hepatoprotective action is associated with the competitive interaction of silymarin with toxins for the corresponding receptors on the hepatocyte membrane; This is due to the membrane-stabilizing effect.

Affects the metabolism and other cellular processes by suppressing the 5-lipoxygenase pathway (in particular leukotriene B4), binding to free reactive oxygen radicals. Accelerates regenerative processes by stimulating the synthesis of proteins (structural and functional) and phospholipids in the affected hepatocytes.

Flavonoids, to which silymarin belongs, also have an antioxidant effect, improve microcirculation. Clinically, these effects are expressed in the improvement of subjective symptoms and in the normalization of indicators of the functional state of the liver (the activity of transaminases, the level of gamma globulin, bilirubin).Improves the overall condition of patients, reduces the number of complaints related to the gastrointestinal tract. In patients with reduced digestion of food associated with liver disease, appetite increases and weight gain occurs.

Pharmacokinetics

After ingestion, Karsil is slowly absorbed from the digestive tract. Undergoes intestinal-hepatic circulation. Do not cum in the body. Metabolised in the liver by conjugation. Mostly (80%) is excreted with bile in the form of glucuronides and sulfates and to an insignificant extent (about 5%) in the urine.

Indications

• toxic liver damage;
• condition after hepatitis;
• chronic hepatitis of non-viral etiology;
• cirrhosis of the liver (as part of complex therapy);
• steatosis of the liver (non-alcoholic and alcoholic);
• for the prevention of long-term use of drugs, alcohol, with chronic intoxication (including professional).

Forms of release

Dragee or tablets 35 mg.

Capsules Karsil forte.

Instructions for use and dosing regimen

Adults and children over 12 years for the treatment of severe liver damage drug prescribed in a daily dose of 420 mg - 4 dragees 3 times a day.

For the treatment of more mild cases and as maintenance therapy, 1-2 tablets are prescribed 3 times a day.

For prevention appoint 2-3 tablets per day.

The course of treatment is at least 3 months.

Dragee should be taken orally, before eating, with plenty of water.

Side effect

• nausea;
• dyspepsia;
• diarrhea;
• itching;
• rash;
• exacerbation of existing vestibular disorders.

Contraindications

• children's age till 12 years;
• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

During pregnancy and lactation (breastfeeding), the use of the drug is not recommended.

special instructions

When using the drug, the manifestation of estrogen-like action of silymarin is possible. Therefore, patients with hormonal disorders (endometriosis, uterine myoma, carcinoma of the breast, ovaries, uterus, prostate gland), the drug is administered with caution.

In the preparation of Karsil, as an auxiliary, wheat starch is contained, which may pose a risk to patients with celiac disease (gluten enteropathy).

Also, as an auxiliary component in the preparation contains glycerol, which in high doses can cause a headache or have an irritating effect on the gastric mucosa.

Drug Interactions

With the joint use of silymarin with oral contraceptives and drugs that are used for hormone replacement therapy, it is possible to reduce the effects of the latter.

Carlos suppresses the cytochrome P450 system and can enhance the effects of such drugs as diazepam, alprazolam, ketoconazole, lovastatin, vinblastine.

Analogues of the drug Karsil

Structural analogs for the active substance:

• Karsil Forte;
• Legalon 140;
• Legal 70;
• Silegon;
• Silibinin;
• Sylimar;
• Silymarin;
• SILIMARIN SEDICO.

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