Foamer - instructions for use, reviews, analogues and forms of release (tablets of vitamins of group B of folic acid and cyanocobalamin) of a drug for the treatment of beriberi in adults, children, during pregnancy and planning. Composition

In this article, you can read the instructions for using the drug Foliber. There are reviews of visitors to the site - consumers of this medication, as well as opinions of physicians specialists on the use of Foliber in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Foliber in the presence of existing structural analogs.Use to treat hypovitaminosis and vitamin deficiency in adults, children, as well as in pregnancy, planning and breastfeeding. Composition of the preparation.

Foliber - a complex of B vitamins.

Folic acid deficiency (active ingredient of Foliber) causes disruption of DNA synthesis in a cell preparing for chromosome replication and fission. The mechanism of action is due to the participation of folic acid in the form of tetrahydrofolate in the synthesis of nucleic acids and in cell division, and also as a coenzyme in the synthesis of purines and pyrimidines, which makes it the decisive factor in the formation of the central nervous system, which develops in humans 15-28 days after fertilization . The conversion of 5-methyl tetrahydrofolate to tetrahydrofolate in the body can occur only as a result of the addition of the methyl group to homocysteine to form methionine as a result of the action of methionine synthetase.

In this process, vitamin B12 participates as a limiting cofactor; therefore, the deficiency of vitamin B12 is similar in the effects of insufficient folic acid activation; In addition, vitamin B12 also participates in the capture of folic acid by cells, so when a cell is experiencing a primary deficiency of vitamin B12, it also experiences a deficit in folate.

Pharmacological action of the drug Foliber is that its use allows you to overcome the metabolic blockade, which is observed in mothers of children with neural tube defects. The specific nature of this metabolic blockade is the metabolism of the essential amino acid methionine, in which folate and vitamin B12 are the key elements, as they are responsible for the re-methylation of homocysteine in methionine. 400 μg of folic acid is the minimum effective daily dose recommended by the Centers for Disease Prevention (US, UK, Australia) to healthy women as an additional daily intake to prevent the development of neural tube defects in the fetus.

The recommended daily intake of vitamin B12 is 2 μg.

Composition

Folic acid (vitamin Bc) + Cyanocobalamin (vitamin B12) + excipients.

Pharmacokinetics

Folic acid is rapidly absorbed in the jejunum, subject to reduction and methylation to 5-methyltetrahydrofolate, which is present in the portal circulation. Cmax in the blood plasma is observed after 30-60 minutes.Also, vitamin B12 can be absorbed after its interaction in the stomach with the "internal Factor of Castle", a glycoprotein that is secreted by parietal cells of the stomach. As with folic acid, vitamin B12 undergoes significant intestinal hepatic recirculation. Vitamin B12 and its metabolite 5-methyltetrahydrofolate largely bind to plasma proteins, excess accumulates in the liver. Vitamin B12 passes through the placenta. Vitamin B12 and folate are excreted in breast milk. Every day, 4-5 μg of folate is excreted in the urine in the form of folic acid, 10-formyltetrahydrofolate and 5-methyl tetrahydrofolate. Part of the administered dose is excreted in the urine for the first 8 hours, although most of it is excreted with bile. 25% is excreted with feces.

Indications

prevention of deficiency of folic acid and vitamin B12 in women of childbearing age at the stages of pregnancy planning (at least 1 month before conception);
for the prevention of neural tube defects in the fetus in the first trimester of pregnancy.

Forms of release

Tablets 400 mcg + 2 mcg.

Instructions for use and reception scheme

The drug should be used 1 tablet a day before meals.

Side effect

allergic reactions

Contraindications

hypersensitivity to the components of the drug.

Application in pregnancy and lactation

The drug Foleiber is used in pregnancy, as well as planning according to the indications.

Use in children

Not noted.

special instructions

Caution should be used in patients with impaired absorption of glucose or galactose, galactosemia or lactase deficiency, since the drug contains 23 mg of lactose in 1 tablet.

Can be used in men at the planning stage.

Impact on the ability to drive vehicles and manage mechanisms

Fiber does not affect the ability to drive and work with machinery.

Drug Interactions

Foliabra should not be used in combination with methotrexate, as the latter acts as a folic acid antagonist, inhibiting the enzyme hydrophotoreductase.

With the simultaneous use of Foliber with antiepileptic drugs from the hydantoin group can reduce the effects of the latter.

Analogues of the drug Foliber

Fiberiber does not have structural analogs for the active substance.The product contains a unique combination of vitamins, which has no analogues.

Analogues on the pharmacological group (vitamins and multivitamins used in the planning of pregnancy):

9 months Vitamin and mineral complex;
9 months Potassium iodide;
9 months Folic acid;
9 months of Omegamam;
Additive of calcium;
Additive with iron;
Aktiferrin compositum;
Aloe syrup with iron;
Alphabet Mamino health vitamin-mineral complex;
Angiovitis;
Ascorbic acid;
Ascofol;
Berrocka Plus;
Vitacalsin;
Vitamineral;
Vitrum the Magician;
Vitrum Prenatal forte;
GinoTardiferon;
Dumil Mama Plus;
Duovit;
Yogulact;
Yogulact forte;
Calcemin;
Calcium Sandoz Forte;
Beresz Plus drops;
Maltofer;
Maltofer Foul;
Moriamin Forte;
Multiproduct for pregnant women;
Oligovit;
Osteogenon;
Osteoka;
Pregnavit;
Pregnacea;
Sorbifer Durules;
Tardiferon;
Totem;
Femibion Natalker 1;
Femibion Natalker 2;
Ferlatum Foul;
Ferretab Comp .;
Ferrum Lek;
Folacin;
Folic acid;
Folio;
Elevit Pronatal.

If there are no analogues of the medication for the active substance, you can go to the links below for diseases, from which the corresponding drug helps,and see the available analogues for therapeutic effects.

Used for the treatment of diseases: vitamin deficiency, Pregnancy planning, avitaminosis, hypovitaminosis, lack of vitamins