Matarin - instructions for use, reviews, analogs and formulations (tablets 7.5 mg and 15 mg, cream or ointment Plus with pepper) for the treatment of pain and inflammation in arthrosis, arthritis, lumbulgia in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Matarin. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Mataren in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Matarin with available structural analogues. Use for the treatment of pain and inflammation with arthrosis, arthritis, lumbulgia in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Matarin non-steroidal anti-inflammatory drug (NSAID). Has anti-inflammatory, antipyretic, analgesic effect. Refers to the class of oxycomams; a derivative of enolic acid. Meloxicam (active substance of the preparation Mataren) inhibits the synthesis of prostaglandins in the inflammation region to a greater extent than in the mucous membrane of the stomach or kidneys, which is associated with a relatively selective inhibition of COX-2. When administered in high doses, prolonged use and individual characteristics of the organism, the selectivity of action against cyclooxygenase type 2 is reduced.

Matarin Plus has anti-inflammatory, analgesic, anti-edematous effect, can cause mild local flushing of the skin, without exerting a pronounced irritant effect on the skin.

Matalen Plus reduces pain in the joints (including in the joints of the spine) and in the muscles at rest and during movement, contributes to an increase in the volume of motion of the joints (in the area of ​​application of the cream). Reduces morning stiffness and swelling of the joints.

Tincture of peppers contains capsaicin, which has an irritant effect on sensitive skin receptors,which leads to a local analgesic effect, to an improvement in blood circulation in the skin and subcutaneous tissue, as well as the warming effect. Improvement of local blood flow is accompanied by increased blood circulation in the underlying tissues, which helps to remove the inflammation substrate from the pathological focus.

Due to the optimal combination of the components of the cream, the mutual enhancement of their analgesic and anti-inflammatory effects is noted. When combined, the active components of Matarin Plus cream have a greater effect due to synergy, compared to the individual effect of each of these components.

Composition

Meloksikam + auxiliary substances.

Meloksikam + Tincture of fruits of chilli peppers + auxiliary substances (Matarin Plus).

Indications

• rheumatoid arthritis;
• rheumatic affections of soft tissues;
• arthrosis (osteoarthritis);
• ankylosing spondylitis (Bekhterev's disease);
• pain syndrome: bursitis, tendonitis, lumbago, sciatica, neuralgia, myalgia, arthralgia, radiculitis, posttraumatic pain syndrome (traumatic bruises, sprains, sprains, muscles and tendons, muscle ruptures without compromising the integrity of the skin),soreness of muscles and joints caused by heavy physical exertion.

Forms of release

Tablets 7.5 mg and 15 mg.

Cream for external use Matarin Plus (sometimes mistakenly called ointment or gel).

Instructions for use and dosing regimen

Pills

Inside, with food, once a day.

In rheumatoid arthritis and ankylosing spondylitis (ankylosing spondylitis) to 15 mg a day, while achieving a positive therapeutic effect, the dose can be reduced to 7.5 mg per day.

For osteoarthritis, 7.5 mg per day, if necessary, increase the dose to 15 mg per day.

The maximum daily dose is 15 mg.

The initial dose in patients with an increased risk of side effects is 7.5 mg per day.

In patients with severe renal impairment on hemodialysis, the maximum daily dose of 7.5 mg.

When slight or moderate decrease in renal function (creatinine clearance of more than 25 ml / min) as well as in liver cirrhosis in a stable clinical condition - correction dose is not required.

Cream Matarin Plus

Outwardly. Slightly rub strip of cream length from 1 to 5 cm, the frequency of application - 1-3 times a day. The amount of cream and frequency of application can vary depending on the area of ​​application and individual reaction to the cream.To enhance the effect, a dry warming bandage can be applied.

Side effect

• dyspepsia, incl. nausea, vomiting, abdominal pain, constipation, flatulence, diarrhea;
• transient increase in hepatic transaminase activity;
• hyperbilirubinemia;
• eructation;
• esophagitis;
• gastroduodenal ulcer;
• bleeding from the digestive tract (including latent);
• stomatitis;
• perforation of the gastrointestinal tract;
• colitis;
• hepatitis;
• gastritis;
• anemia;
• change in the blood formula, incl. leukopenia, thrombocytopenia;
• itching;
• skin rash;
• hives;
• photosensitization;
• bullous eruptions;
• multiform erythema, incl. Stevens-Johnson syndrome;
• toxic epidermal necrolysis;
• bronchospasm;
• dizziness;
• headache;
• vertigo;
• noise in ears;
• drowsiness;
• confusion of consciousness;
• disorientation;
• emotional lability;
• peripheral edema;
• increased blood pressure;
• palpitation;
• "tides" of blood to the skin of the face;
• hypercreatininaemia and / or elevated urea in the blood serum;
• acute renal insufficiency;
• conjunctivitis;
• impaired vision, incl. blurred vision;
• angioedema;
• anaphylactoid / anaphylactic reactions.

Contraindications

• hypersensitivity to any component of the drug, as well as non-steroidal anti-inflammatory drugs of other groups;
• presence in the history of attacks of bronchial asthma, urticaria or acute rhinitis, provoked by the intake of acetylsalicylic acid or other non-steroidal anti-inflammatory drugs (NSAIDs);
• exacerbation of peptic ulcer of the stomach and duodenum;
• severe hepatic impairment;
• severe heart failure;
• chronic renal failure in patients not undergoing hemodialysis;
• Gastrointestinal, cerebrovascular or other bleeding;
• violation of the integrity of the skin and inflammatory skin diseases at the site of the intended application of the drug (for cream);
• children's age (up to 12 years);
• pregnancy, lactation.

Application in pregnancy and lactation

The use of Matarin during pregnancy is contraindicated.

During the lactation period, when the drug is used, the question of stopping breastfeeding should be addressed.

Use in children

The drug is contraindicated for children under 12 years.

Application in elderly patients

The drug should be used with caution in elderly patients.

special instructions

In the event of peptic ulcers or gastrointestinal bleeding, the development of side effects from the skin and mucous membranes, the drug Mataren should be discarded.

In patients with reduced circulating blood volume and reduced glomerular filtration (dehydration, chronic heart failure, cirrhosis, nephrotic syndrome, clinically pronounced kidney disease, diuretics, dehydration after major surgery), there may be a clinically pronounced chronic renal failure that is completely reversible after withdrawal of the drug (in these patients at the beginning of treatment should monitor diuresis and renal function).

With a persistent and significant increase in transaminases and changes in other indicators of liver function, the drug should be withdrawn and control tests carried out. In patients with an increased risk of side effects, treatment starts with a dose of 7.5 mg. In the terminal stage of chronic renal failure in patients on hemodialysis, the dose should not exceed 7.5 mg per day.

Impact on the ability to drive vehicles and manage mechanisms

During the treatment period, care must be taken (when dizziness and drowsiness occur) when driving vehicles and engaging in other potentially hazardous activities requiring increased concentration of attention and speed of psychomotor reactions.

Drug Interactions

With simultaneous administration with other non-steroidal anti-inflammatory drugs, the risk of ulcerative lesions of the gastrointestinal tract and gastrointestinal bleeding increases.

Matarin increases the concentration of lithium in plasma.

Reduces the effectiveness of intrauterine contraceptives, hypotensive drugs.

Avoid contact with the cream on the damaged skin, eyes and mucous membranes. If you get Matarin Plus cream on these areas, you should remove it with a cotton swab impregnated with vaseline or vegetable oil.

After using the cream, you should thoroughly wash your hands.

Indirect anticoagulants, ticlopidine, heparin, thrombolytics increase the risk of bleeding.Methotrexate enhances myelodepressant effect, it is not recommended to share Methotrexate in a dose of more than 15 mg per week. Diuretics increase the risk of kidney dysfunction. Cyclosporine increases nephrotoxicity. Kolestyramin accelerates excretion.

Myelotoxic drugs increase the manifestation of hematotoxicity of the drug.

Analogues of the drug Mataren

Structural analogs for the active substance:

• Amelotex;
• Arthrosan;
• BiKsikam;
• Lem;
• Liberalum;
• Matarin Plus;
• Medsikam;
• Melbeck;
• Melbek forte;
• Melokvitis;
• Meloks;
• Meloksam;
• Meloksikam;
• Meloflam;
• Meloflex Rompharm;
• Mesipol;
• Mixol OD;
• Mirlocks;
• Movalis;
• Movasin;
• Movix;
• Oxycamox;
• Flexibon;
• Exen Sanovel.

Analogues on the curative effect (agents for the treatment of arthrosis):

• Alflutop;
• Amelotex;
• Apizarthron;
• Arkoxy;
• Arthra;
• Artradol;
• Arthrosylen;
• Aertal;
• Voltaren;
• Gialgan Phidias;
• Hydrocortisone;
• Dexalgin;
• Diqlovit;
• Diclosan forte;
• Dicloran plus;
• Diclofenac;
• Dimexide;
• Diprospan;
• Diskus compositum;
• Dolgit;
• Don;
• Durogesic;
• Indomethacin Sopharma;
• Inoltra;
• Kalmireks;
• Ketonal;
• Ketoprofen;
• Ketorol;
• Xsefokam;
• Adhesive plaster medical Dorsaplast;
• Adhesive plaster medical Nanoplast forte;
• Meloksikam;
• Midokalm;
• Movalis;
• Nyz;
• Naklofen;
• Neurodiclavitis;
• Nemux;
• Nimesil;
• Nimesulide;
• Piroxicam;
• Sirdalud;
• Structum;
• Teraflex;
• Teraflex Advance;
• Fendivia;
• Finalgon;
• Flamadex;
• Flamax;
• Hondrogaard;
• Chondroxide;
• Chondroxide ointment;
• Celebrex;
• The purpose of T;
• Cycloferon;
• Citralgin;
• Elbon;
• Espoo.

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