En DE FR ES PL
Z Factor - instructions for use, analogs, reviews and release forms (suspension, 250 mg capsules, 500 mg tablets) of the antibiotic drug for the treatment of angina, bronchitis, pneumonia in adults, children and pregnancy. Composition and alcohol

Z Factor - instructions for use, analogs, reviews and release forms (suspension, 250 mg capsules, 500 mg tablets) of the antibiotic drug for the treatment of angina, bronchitis, pneumonia in adults, children and pregnancy. Composition and alcohol

In this article, you can read the instructions for using the drug Z Factor. There are reviews of visitors to the site - consumers of this medication, as well as opinions of physicians specialists on the use of Z Factor in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Z Factor in the presence of existing structural analogs.Use for the treatment of angina, bronchitis, pneumonia and other infectious diseases in adults, children, as well as during pregnancy and lactation. Composition and interaction of the drug with alcohol.

 

Z Factor - antibiotic group of macrolides, is a representative of azalides. Suppresses RNA-dependent protein synthesis of sensitive microorganisms.

 

It is active against gram-positive bacteria: Staphylococcus aureus (Staphylococcus aureus), Streptococcus spp. (streptococcus) (including Streptococcus pneumoniae, Streptococcus pyogenes (group A)); Gram-negative bacteria: Haemophilus influenzae, Haemophilus parainfluenzae, Haemophilus ducreyi, Moraxella catarrhalis, Escherichia coli, Bordetella pertussis, Bordetella parapertussis, Borrelia burgdorferi, Neisseria gonorrhoeae, Campylobacter spp., Legionella pneumophila (Legionella); anaerobic bacteria: Bacteroides fragilis.

 

Azithromycin is also active against Chlamydia trachomatis (chlamydia), Mycoplasma pneumoniae (Mycoplasma), Mycoplasma hominis, Treponema pallidum (treponema).

 

It is also active against Toxoplasma gondii (toxoplasma).

 

Composition

 

Azithromycin (in the form of dihydrate) + auxiliary substances.

 

Pharmacokinetics

 

Quickly absorbed from the digestive tract. Eating lowers the absorption of azithromycin. Cmax in plasma is achieved in 2-3 hours. It is quickly distributed in tissues and biological fluids. 35% of Azithromycin is metabolized in the liver by demethylation. More than 59% is excreted in bile in unchanged form, about 4.5% - with urine in unchanged form.

 

Indications

 

Infectious-inflammatory diseases caused by microorganisms susceptible to azithromycin:

  • angina (tonsillitis);
  • bronchitis;
  • pneumonia;
  • infections of the skin and soft tissues;
  • otitis media;
  • sinusitis or sinusitis;
  • pharyngitis;
  • gonorrheal and non-nasal urethritis and / or cervicitis;
  • Lyme disease (borreliosis).

 

Forms of release

 

Powder for the preparation of a suspension for oral administration.

 

Capsules 250 mg.

 

The tablets covered with a cover of 500 mg.

 

Instructions for use and dosage

 

Inside, 1 hour before or 2 hours after meals 1 time per day.

 

Adults with upper and lower respiratory tract infection - 500 mg per day for 3 days (course dose - 1500 mg); with infections of the skin and soft tissues - 1000 mg per day on the first day, then (2-5 days) - 500 mg per day (course dose - 3000 mg); with acute infections of the urogenital organs (uncomplicated urethritis or cervicitis) - 1000 mg once; with Lyme disease (treatment of the initial stage - erythema migrans) - 1000 mg per day on the first day, then (2-5 days) - 500 mg per day (course dose - 3000 mg); with gastric ulcer and duodenal ulcer associated with Helicobacter pylori (Helicobacter) - 1000 mg per day for 3 days as part of complex therapy.

 

Children 10 mg / kg body weight for 3 days or on the first day 10 mg / kg, then 4 days 5 mg / kg per day (course dose 30 mg / kg), in the treatment of erythema migrans 20 mg / kg on the first day, then (2-5 days) - 10 mg / kg.

 

Side effect

  • nausea, vomiting;
  • flatulence;
  • diarrhea;
  • stomach ache;
  • transient increase in hepatic enzyme activity;
  • cholestatic jaundice;
  • skin rash;
  • angioedema;
  • erythema multiforme;
  • Stevens-Johnson syndrome;
  • toxic epidermal necrolysis;
  • photosensitization;
  • dizziness;
  • headache;
  • drowsiness;
  • weakness;
  • leukopenia, neutropenia, thrombocytopenia;
  • pain in the chest;
  • vaginitis;
  • thrush or candidiasis;
  • nephritis;
  • increasing residual urea nitrogen;
  • hyperglycemia;
  • arthralgia.

 

Contraindications

  • increased sensitivity to azithromycin and other antibiotics of the macrolide group.

 

Application in pregnancy and lactation

 

Azithromycin penetrates the placental barrier. Use in pregnancy is possible only in cases where the intended benefit to the mother exceeds the potential risk to the fetus.

 

If it is necessary to use Z Factor in the lactation period, the question of stopping breastfeeding should be solved.

 

Use in children

 

The application is possible according to the dosing regimen. It is more preferable for children to use the drug in the form of a suspension.

 

special instructions

 

It is not recommended for use in patients with impaired liver function.

 

Use with caution for violations of kidney function.

 

Azithromycin should be taken at least 1 hour before or 2 hours after ingestion or antacids.

 

Drug Interactions

 

With the simultaneous application of ergot alkaloids, one can not exclude the risk of ergotism.

 

With the simultaneous use of Z Factor with warfarin, cases of amplification of the effects of the latter are described.

 

It is not recommended joint use of the drug ZiFactor with alcohol because of the possible development of hepatotoxic reactions.

 

With the simultaneous use of Digoxin or digitoxin with azithromycin, a significant increase in the concentration of cardiac glycosides in the blood plasma and the risk of developing glycosidic intoxication are possible.

 

With simultaneous use with disopyramide, the case of ventricular fibrillation has been described.

 

With simultaneous application with lovastatinom, cases of rhabdomyolysis have been described.

 

With simultaneous use with rifabutin increases the risk of developing neutropenia and leukopenia.

 

With simultaneous use, the metabolism of cyclosporine is disrupted, which increases the risk of side effects and toxic reactions,caused by cyclosporin.

 

Analogues of the drug Zi Factor

 

Structural analogs for the active substance:

  • Azibiot;
  • Azivok;
  • Azidrop;
  • Azimycin;
  • AsitRus;
  • AzitRus forte;
  • Azitral;
  • Azitroxy;
  • Azithromycin;
  • Azicid;
  • Zetamax retard;
  • Zitnob;
  • Zitrolide;
  • Zitrolid forte;
  • Zitrocin;
  • Suitrox;
  • Sumazid;
  • Sumaclide;
  • Sumaclid 1000;
  • Sumamed;
  • Sumamed forte;
  • Sumamecin;
  • Sumamecin forte;
  • Sumamox;
  • Sumatrolide Solidshn Tablets;
  • Sumatrolide solute;
  • Tremak Sanovel;
  • Hemomycin;
  • Ecomed.

Similar medicines:

Other medicines:

Reviews (0):

Rules for publishing reviews and visitor questions