Cefazolin - instructions for use, reviews, analogs and forms of release (injections in injections) for the treatment of angina, sepsis and other infections in adults, children and pregnancy. Solution dilution

In this article, you can read the instructions for using the drug Cefazolin. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of experts on the use of Cefazolin in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Cefazolin in the presence of existing structural analogues. Use for the treatment of angina, sepsis and other infections in adults, children, as well as during pregnancy and lactation.

Cefazolin - 1 generation cephalosporin antibiotic. It is bactericidal.

Has a wide spectrum of antimicrobial action. It is active both against gram-positive and gram-negative microorganisms. It is also active against Spirochaetaceae and Leptospiraceae.

The drug is not effective against P. aeruginosa, indolpositive strains of Proteus spp., M. tuberculosis, anaerobic microorganisms.

Pharmacokinetics

When ingestion is destroyed. Penetrates into the organs and tissues of the body (including joints, SSS, abdominal cavity, kidney and urinary tract, middle ear, placenta, respiratory tract, skin and soft tissues). In patients with normal bile duct function, the concentration in the gallbladder and bile tissues is significantly higher than in plasma. With obstruction of the bile ducts, the concentration in the bile is much less than in the plasma. Metabolised in the liver. It is excreted by the kidneys unchanged during the first 6h - 60-90%, after 24 hours - 70-95%.

Indications

Infectious-inflammatory diseases caused by drug-susceptible pathogens:

• sepsis;
• peritonitis;
• endocarditis;
• respiratory tract infections;
• infections of the urinary tract, including, syphilis and gonorrhea;
• infectious lesions of bones and joints.

Prevention of postoperative complications.

Forms of release

Powder for the preparation of solution for intravenous and intramuscular injection (injections in ampoules for injection).

Instructions for use and dosage

Intramuscularly, intravenously (struino and drip (as a dropper)). The average daily intake for adults is 0.25-1 g; the frequency of administration is 2-4 times a day. The maximum daily dose is 6 g (in rare cases - 12 g). The average duration of treatment is 7-10 days.

For the prevention of postoperative infection - 1 g intravenously 0.5-1 h before surgery, 0.5-1 g - during the operation and 0.5-1 g every 8 h during the first 24 hours after the operation.

Children 1 month and older - 25-50 mg / kg per day; In severe infection, the dose may be increased to 100 mg / kg per day. Multiplicity of administration - 2-4 times a day.

Preparation of solutions for injection and infusion: 0.5 g of the drug is dissolved in 2 ml of water for injection (can be used in case of intramuscular injection of Novocaine to reduce pain at the injection site), 1 g in 4 ml of water for injection. For IV bolus injection, the resulting solution is diluted with 5 ml of water for injection, then injected slowly for 3-5 minutes.For intravenous administration of the drug, dilute 50-100 ml of 5% or 10% solution of dextrose, 0.9% solution of sodium chloride, Ringer's solution, 5% sodium bicarbonate solution.

During the dilution, vials should be vigorously shaken until completely dissolved.

Side effect

• hives;
• chills;
• fever;
• rash;
• itching;
• bronchospasm;
• angioedema;
• anaphylactic shock;
• nausea, vomiting;
• diarrhea or constipation;
• flatulence;
• abdominal pain;
• dysbiosis;
• stomatitis;
• glossitis;
• pseudomembranous enterocolitis;
• leukopenia, neutropenia, granulocytopenia, thrombocytopenia, hemolytic anemia;
• impaired renal function (azotemia, increased urea levels in the blood, hypercreatininaemia);
• anal itching;
• itching of the genitals;
• phlebitis;
• soreness along the veins;
• morbidity and infiltration at the site of intramuscular injection;
• superinfection;
• candidiasis.

Contraindications

• pregnancy;
• lactation;
• hypersensitivity to cephalosporin group preparations and other beta-lactam antibiotics.

Do not appoint a newborn.

Application in pregnancy and lactation

Contraindicated taking the drug during pregnancy. If necessary, breast-feeding is stopped.

special instructions

Patients who had a history of allergic reactions to penicillins, may have increased sensitivity to cephalosporin antibiotics.

With caution, the drug is prescribed to patients with gastrointestinal diseases (especially with colitis).

When using cefazolin, positive direct and indirect Coombs probes may appear.

With cefazolin, a false positive reaction to glucose in the urine is possible.

The safety of the drug in preterm infants and children of the first month of life is not established.

Drug Interactions

It is not recommended simultaneous reception with anticoagulants and diuretics.

Loop diuretics and drugs that block tubular secretion increase the concentration of cefazolin in the plasma.

Aminoglycosides increase the risk of kidney damage.

Pharmaceutically incompatible with aminoglycosides (mutual inactivation). To prepare a solution for intravenous administration (jet or drip), Lidocaine can not be used.

Analogues of the drug Cefazolin

Structural analogs for the active substance:

• Anceph;
• Zolin;
• Intrazoline;
• Iphizol;
• Kefzol;
• Lysolin;
• Nacef;
• Orizolin;
• Orpin;
• Totatsef;
• Cesolin;
• Cefazolin sodium;
• Cefazolin Sandoz;
• Cefazolin Elfa;
• Cefazolin "Biohemi";
• Cefazolin-AKOS;
• Cefazolin-Ferein;
• Cefazolin sodium salt;
• Cefamezin;
• Cefaprim;
• Cephezole;
• Cefopride.

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