Sumatriptan - instructions for use, analogs, reviews and release forms (tablets 50 mg and 100 mg, injections in ampoules) of a drug for the treatment of migraine and relief of headache in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Sumatriptan. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of experts on the use of Sumatriptan in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Sumatriptan analogues in the presence of existing structural analogs.Use for the treatment of migraine and relief of headache attacks in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Sumatriptan - Means for the treatment of migraine; agonist of serotonin 5-HT1 receptors. The therapeutic effect of sumatriptan is apparently due to two mechanisms: the substance excites the serotonin 5-HT1 receptors of the smooth muscles of the vessels of the carotid arteries system and causes their narrowing. Sleepy arteries supply blood to the head tissue, incl. meninges; with the expansion of the vessels of the membranes of the brain, the occurrence of migraine attacks is associated. In addition, sumatriptan activates the receptors of the endings of the afferent fibers of the trigeminal nerve in the dura mater, resulting in a decrease in the isolation of sensory neuropeptides. Sumatriptan poorly penetrates the blood-brain barrier (BBB) ​​and, according to experimental data, does not have proper analgesic properties.

The effect of sumatriptan usually occurs 30 minutes after ingestion and 10-15 minutes after subcutaneous injection.

Composition

Sumatriptan + auxiliary substances.

Pharmacokinetics

Quickly absorbed when taken orally.Bioavailability is 15% due to presystemic metabolism and incomplete absorption. The level of binding to plasma proteins is low (14-21%). Biotransformed with the participation of MAO, mainly MAO A, with the formation of metabolites, the main ones being the indoleacetic analog of sumatriptan, not having pharmacological activity against 5-HT1 and 5-HT2 receptors, and its glucuronide; secondary metabolites are not identified. It is excreted by the kidneys (renal excretion - about 60%, mainly in the form of inactive metabolites - 97%), the rest is excreted with feces.

Indications

• relief of migraine attacks and Horton's syndrome (histamine cephalalgia).

Forms of release

Tablets coated with 50 mg and 100 mg.

Solution for subcutaneous injections (injections in ampoules for injection).

Other dosage forms, whether nasal spray or capsules, do not exist.

Instructions for use and dosing regimen

To stop a migraine attack for ingestion, the dose is 100 mg once; sometimes an effective dose may be less than 100 mg; in case of resumption of an attack, repeated administration is possible, with the daily dose not exceeding 300 mg.Subcutaneously injected at a dose of 6 mg; if necessary, repeated injection at the same dose can be performed no earlier than 1 hour after the first administration; the maximum daily dose of sc - 12 mg.

Do not use sumatriptan for arresting migraine attacks more than 10 times a month (10 days a month). If you need to use the drug more often - contact your doctor to confirm the diagnosis.

With Horton's syndrome injected sc in a dose of 6 mg once during an attack; the maximum daily dose is 12 mg; the interval between injections is at least 1 hour.

Side effect

• dizziness;
• weakness;
• drowsiness;
• arterial hypotension or a short-term increase in blood pressure;
• bradycardia or tachycardia;
• nausea, vomiting;
• rashes on the skin;
• erythema;
• itching;
• with n / to the introduction - a short-term pain at the injection site;
• sensation of heat;
• tingling;
• pain;
• pressure or compression in different parts of the body.

Contraindications

• IHD;
• arterial hypertension;
• simultaneous administration of preparations containing ergot alkaloids or close to them compounds, lithium preparations, inhibitors of reverse neuronal seizure of serotonin;
• simultaneous administration of MAO inhibitors and up to 14 days after their withdrawal;
• hypersensitivity to sumatriptan.

Application in pregnancy and lactation

The clinical experience of Sumatriptan in pregnancy is limited, and therefore it is contraindicated for use.

With caution should be used during lactation. It is not recommended to breast-feed a baby for 24 hours after taking sumatriptan.

Use in children

Safety and effectiveness of use in children and adolescents under the age of 18 years is not established.

special instructions

Sumatriptan is not used to prevent or prevent migraine attacks.

They are used with caution for violations of the liver and kidney function, as well as in patients with epilepsy or other disorders of the brain.

When relieving seizures, treatment should be started as soon as possible, however, the introduction of sumatriptan during the aura period, before the appearance of other symptoms, may not prevent the onset of a headache.

When treating Sumatriptan, symptoms sometimes appear that resemble angina attacks - pain, a feeling of contraction in the chest. In this regard, sumatriptan should not be used in cases of suspected undiagnosed diseases of the heart and blood vessels,before conducting an appropriate survey.

If there is no effect on the first dose of sumatriptan, it is necessary to verify the diagnosis.

Safety and effectiveness of use in children and adolescents under the age of 18 years is not established.

Impact on the ability to drive vehicles and manage mechanisms

When migraine, as well as against the background of therapy Sumatriptan, it is possible the development of drowsiness. Therefore, during the period of application, patients should be very careful to drive and engage in other potentially hazardous activities requiring high rates of psychomotor reactions.

Drug Interactions

With simultaneous application with lithium salts, cases of the development of serotonin syndrome have been described.

With simultaneous use with moclobemide, bioavailability of moclobemide increases in the absence of clinical manifestations.

With simultaneous use with rizatriptan there is a risk of additive hyperstimulation of serotonin 5-HT1 receptors; with ergotamine - possible the development of vasospasm.

With simultaneous application of herbal preparations of St. John's wort, it is possible to increase serotonergic effects and development of side effects.

Analogues of medicinal product Sumatriptan

Structural analogs for the active substance:

• Amigrenin;
• Imigran;
• Migrapam;
• Rapimed;
• Sumygamren;
• Sumarin;
• Sumatriptan Adifarm;
• Sumatriptan Pfizer;
• Sumatriptan Teva;
• Sumatriptan succinate;
• Sumitran;
• Trimigrene.

Analogues on the curative effect (funds for the treatment of migraine):

• Amitriptyline;
• Analgin;
• Andipal;
• Ascofen;
• Aspirin;
• Acetaminophen;
• Betalk;
• Bromazepam;
• Vazobral;
• Vasocardine;
• Valerian;
• Vinpotropil;
• Histaglobin;
• Diltzer;
• Dimephosphone;
• Zomig;
• Zorex Morning;
• Inderal;
• Ipronal;
• Xantinol nicotinate;
• Kudevita;
• Lexotan;
• Metovit;
• MIG 200;
• Naisylate;
• Nalgezin;
• Nalgezin forte;
• Nekstrim Active;
• Next;
• Nilogrin;
• Noblessite;
• Novigan;
• NovoPassit;
• Nomigren;
• Obsidan;
• Omaron;
• Optinat;
• Paracetamol;
• Pentalgin;
• Pikamilon;
• Pliwalgin;
• Redergin;
• Rudotel;
• Sinkapton;
• Sinusan;
• Solpadein;
• Stugeron;
• Topamax;
• Topiramate;
• A sedative (sedative) collection;
• Febricet;
• Fezam;
• Hyrumat;
• Cefexon;
• Cinnarizine;
• Estecor;
• Efkamon.

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