Kolofort - instructions for use, analogs, reviews and release forms (tablets for resorption) of the drug for the treatment of irritable bowel syndrome and dyspepsia in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Colorado. Comments of visitors of the site - consumers of this medication, as well as opinions of specialists on the use of Kolofort in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Kolofort in the presence of existing structural analogues. Use for the treatment of irritable bowel syndrome and functional dyspepsia in adults, children, as well as in pregnancy and lactation. Composition of the preparation.

Colorado - the combination of the three active components allows for a complex effect on the central and peripheral links of the pathogenesis of functional disorders of the intestine, including. abdominal pain syndrome.

It has been shown experimentally that the components of the preparation modify the activity of the ligand-receptor interaction of endogenous regulators with corresponding receptors: antibodies to the S-100 protein to serotonin receptors and sigma-1 receptors; antibodies to TNF-alpha to the TNF-alpha receptor; antibodies to histamine - to the H4-histamine receptors located in the digestive tract.

Antibodies to protein S-100 have a wide spectrum of psychotropic activity, including anxiolytic and antidepressant, anti-asthenic and nootropic effects, which clinically manifests itself in the elimination of internal tension, anxiety, and normalization of a number of visceral functions, incl. activity of the large intestine. Do not have a sedative effect, do not cause addiction, withdrawal syndrome.

Antibodies to TNF-alpha have a pronounced anti-inflammatory effect, contribute to the normalization of the balance of proinflammatory and anti-inflammatory cytokines.

Antibodies to histamine have antispasmodic, anti-inflammatory, anti-edematous action.

Combined use of components in the complex preparation contributes to the normalization of nervous and humoral regulation of bowel function, reduction of visceral hypersensitivity of colon receptors to stretching, providing restoration of impaired motility of the gastrointestinal tract; a cupping sensation of bloating and stomach overflow; reduce the severity of pain. The antispasmodic effect of the drug is manifested by relaxation of the smooth muscle and a decrease in the tone of the gastrointestinal wall, a reduction in intraluminal pressure, normalization of the consistency of the stool, its frequency and accompanying symptoms (including relief of imperative urges, tenesmus, feelings of incomplete evacuation of the intestine, reduction of additional efforts in the act of defecation) .

Composition

Antibodies to human TNF-alpha affinity purified + Antibodies to the brain-specific protein S-100 affinity purified + Antibodies to histamine affinity purified + excipients.

Antibodies are applied to lactose in the form of a mixture of three active water-alcohol dilutions of the substance,diluted respectively in 100 in the 12th degree, 100 in the 30th degree, 100 in the 200th degree, therefore it is permissible to call Kolofort a homeopathic remedy.

Pharmacokinetics

The sensitivity of modern physicochemical methods of analysis (gas-liquid chromatography, high-performance liquid chromatography, chromatography-mass spectrometry) does not allow to estimate the content of ultra-small doses of antibodies in biological fluids, organs and tissues, which makes it technically impossible to study the pharmacokinetics of the preparation Colforth.

Indications

• irritable bowel syndrome;
• functional disorders of the digestive tract (functional dyspepsia).

Forms of release

Lozenges.

Other dosage forms, be it drops, solution or capsules, do not exist.

Instructions for use and reception scheme

Inside, not during meals (30 minutes before meals or 2 hours after meals), keep in your mouth until completely dissolved.

At one time - 1 or 2 tablets. Take 2 times a day. The course of treatment - 1-3 months; If necessary, the course of treatment can be extended to 6 months and / or repeat after 1-2 months. Against the background of exacerbation of diseases, it is possible to increase the frequency of admission up to 4 times a day for a period of 7 to 14 days.

Side effect

• reactions of increased individual sensitivity to the components of the drug.

Contraindications

• increased individual sensitivity to the components of the drug.

Application in pregnancy and lactation

Not studied.

Use in children

Not noted.

special instructions

The composition of the drug includes lactose, and therefore it is not recommended to appoint it to patients with congenital galactosemia, glucose malabsorption syndrome or galactose, or with congenital lactase insufficiency.

Influence on ability to drive vehicles and work with mechanisms

Coloring does not affect the ability to drive vehicles and potentially dangerous mechanisms.

Drug Interactions

Cases of incompatibility with other drugs have not been registered to date.

Analogues of the drug Colofort

Structural analogues of the active ingredient have no medicine. The drug on the basis of a combination of homeopathic components has no analogs on the active substance.

Analogues on the curative effect (remedies for the treatment of irritable bowel syndrome):

• Bactistatin;
• Betamax;
• Galidor;
• Guttasil;
• Dicetel;
• Duspatalin;
• Iberogast;
• Irmalax (dietary fiber with vitamin C and citrus flavor);
• Lactofiltrum;
• Meteopazmil;
• Mukofalk;
• Neobutin;
• Neointestopan;
• But the spine;
• But the forte;
• Novo Passit;
• Novobispol;
• Papaverine;
• Platyphylline;
• Probiophore;
• Spasmonet;
• Spasmonet forte;
• Spacock;
• Sparex;
• Trimedate;
• Ulkavis;
• Eglek;
• Enterosan.

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