Rabeprazole - instructions for use, analogs, reviews and release forms (capsules or tablets 10 mg and 20 mg) drugs for the treatment of stomach and duodenal ulcers, gastritis, reflux in adults, children and pregnancy. Composition
In this article, you can read the instructions for using the drug Rabeprazole. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Rabeprazole in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of rabeprazole in the presence of existing structural analogues. Use to treat stomach and duodenal ulcers, gastritis,reflux in adults, children, as well as during pregnancy and lactation. Composition of the preparation.
Rabeprazole - antiulcer, inhibitor of H-K-ATPase (proton pump). The mechanism of action is associated with inhibition of the enzyme H-K-ATPase in the parietal cells of the stomach, which leads to blocking the final stage of the formation of hydrochloric acid. This action is dose-dependent and leads to inhibition of both basal and stimulated secretion of hydrochloric acid regardless of the nature of the stimulus.
Composition
Rabeprazole sodium + excipients.
Pharmacokinetics
After oral intake absorbed from the digestive tract. At a dose of 20 mg Cmax is achieved through 3.5 hours. Bioavailability of rabeprazole does not increase with multiple admission. The intake of food and time of reception during the day does not affect the absorption of rabeprazole. Binding to plasma proteins is 97%. Rabeprazole sodium is subjected to the effect of the first passage. Metabolized in the liver with the participation of isoenzymes of the CYP system. Approximately 90% is excreted in the urine mainly in the form of two metabolites: a conjugate of mercaptopuric acid and a carboxylic acid. In toxicological studies, 2 unidentified metabolites were found in laboratory animals. The rest is excreted with feces.In elderly patients the excretion of rabeprazole is somewhat slowed down.
Indications
- peptic ulcer of the stomach and duodenum in the phase of exacerbation;
- peptic ulcer of the stomach and duodenum, associated with Helicobacter pylori (Helicobacter) (in combination with antibiotics);
- gastritis;
- gastroesophageal reflux.
Forms of release
Capsules enteric-soluble 10 mg and 20 mg (sometimes mistakenly called tablets).
Instructions for use and dosing regimen
Inside, in the morning, before eating, without chewing or chopping. 20 mg once a day; with gastric ulcer and duodenal ulcer in the acute stage - for 4-6 weeks, if necessary - up to 12 weeks; with reflux-esophagitis - 4-8 weeks, later maintenance therapy is possible: 10-20 mg once a day; With Zollinger-Ellison syndrome, the dose is selected individually. With H. pylori infection as part of eradication therapy with the appropriate combinations of antibiotics for 7 days.
Side effect
- diarrhea, constipation;
- nausea, vomiting;
- stomach ache;
- flatulence;
- dry mouth;
- dyspepsia;
- eructation;
- anorexia;
- gastritis;
- stomatitis;
- increased activity of hepatic transaminases;
- headache;
- asthenia;
- dizziness;
- insomnia;
- nervousness;
- drowsiness;
- depression;
- impaired vision and taste;
- rhinitis;
- pharyngitis;
- cough;
- sinusitis;
- bronchitis;
- skin rash;
- itching;
- back pain;
- influenza-like syndrome;
- myalgia;
- chest pain;
- chills;
- cramps of the calf muscles;
- urinary tract infection;
- arthralgia;
- fever;
- increase in body weight;
- increased sweating;
- leukocytosis.
Contraindications
- pregnancy;
- lactation period (breastfeeding);
- childhood;
- increased sensitivity to rabeprazole sodium or substituted benzimidazoles.
Application in pregnancy and lactation
Rabeprazole is contraindicated in pregnancy and lactation.
In experimental studies it was found that rabeprazole penetrates insignificantly through the placental barrier, but there were no violations of fertility or fetal development defects; is excreted with the milk of lactating rats.
Use in children
Clinical experience of using rabeprazole in children is not available, therefore, the use is not recommended.
special instructions
Before the beginning of therapy it is necessary to exclude malignant neoplasms of the stomach, tk.The use of rabeprazole can mask symptoms and delay proper diagnosis.
Patients with hepatic or renal dysfunction are not required to adjust the dose, however, in patients with severe impairment of liver function, it is recommended that rabeprazole be used with caution.
When used simultaneously with rabeprazole, the dosages of Ketoconazole and Digoxin should be adjusted.
In experimental studies, carcinogenic effects of rabeprazole have not been established, however, in the study of mutagenicity, ambiguous results were obtained. Tests on lymphoma cells in mice were positive, while the micronucleus test and the DNA repair test were negative.
Impact on the ability to drive vehicles and manage mechanisms
In case of occurrence of drowsiness it is necessary to refuse driving of the car and other kinds of the activity demanding the raised concentration of attention.
Drug Interactions
With simultaneous use with digoxin, an increase (from small to moderate) of digoxin concentration in the blood plasma is possible.
With simultaneous application with ketoconazole, its bioavailability decreases.
Patients concurrently with rabeprazole receiving ketoconazole or digoxin need additional observation (dosage adjustment of these drugs may be required).
Concentrations of rabeprazole and the active metabolite of Clarithromycin in plasma with simultaneous admission are increased by 24 and 50%, respectively. This increases the effectiveness of this combination in the eradication of Helicobacter pylori. In the study, no interaction of rabeprazole with liquid antacids was found. There was no clinically significant interaction of rabeprazole with food.
Analogues of the drug Rabeprazole
Structural analogs for the active substance:
- Beret;
- Zolispan;
- Zulbeks;
- Нофлюкс;
- Ontime;
- Parries;
- Rabelock;
- Rabeprazole sodium;
- Rabeprazole OBL;
- Rabeprazole SZ;
- Razo;
- Hyrabezole.
Analogues for the pharmacological group (proton pump inhibitors):
- Acrylase;
- Vimovo;
- Gastrozole;
- Dexylant;
- Demeprazole;
- A zerocide;
- Zipantola;
- Zolispan;
- Zolser;
- Controllers;
- Chrismel;
- Crosatide;
- Lanzap;
- Lansoprazole;
- Lancid;
- Losek;
- Nexium;
- Nolpaz;
- Omez;
- Omez Insta;
- Omeprazole;
- Omeface;
- Ontime;
- Pantaz;
- Pantoprazole;
- Parries;
- Pepazol;
- Pepticum;
- Pylobact;
- Romesque;
- Sunpras;
- Ulzol;
- Ulcozol;
- Ulter;
- Ultop;
- Helithrix;
- Helicid;
- Helol;
- Cisagast;
- Esomeprazole;
- Emanera;
- Epicurus.
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