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Laferon - instructions for use, reviews, analogs and forms of release (drops in the nose PharmBiotok Nasal, injections in ampoules for injection of lyophilizate) drug for treatment of acute respiratory viral infections, influenza, herpes in adults, children and pregnancy. Composition

Laferon - instructions for use, reviews, analogs and forms of release (drops in the nose PharmBiotok Nasal, injections in ampoules for injection of lyophilizate) drug for treatment of acute respiratory viral infections, influenza, herpes in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Laferon. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Laferon in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Laferon Analogues in the presence of existing structural analogs.Use to treat and prevent ARVI, influenza, herpes and hepatitis in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

 

Laferon - has a wide range of biological activity. The most important is a pronounced immunostimulating and antiviral action, activation of antitumor protection. The regulation between the links of humoral immunity and cellular is carried out. Under the influence of the drug differentiation is accelerated, and also the activity of cells, which are natural killers, and T-lymphocytes, which determine the activity of the course of cellular immunity reactions, increases.

 

Laferon regulates the production of inflammatory mediators, and also influences the migration of inflammatory cells into the focus of infection, stimulates phagocytosis, normalizes the dynamics of the inflammatory process. The effect of the drug on the expression of molecules in the main histocompatibility complex and the cytokine spectrum determines their antiallergic effect.

 

Laferon affects the main stages of replication of pathogens within cells, stopping their multiplication, ensuring the effectiveness of lysis of infectious agents. It also has high antichlamydia and antiviral activity.Its use in the complex treatment of infectious and inflammatory chronic diseases significantly reduces the dose of antibacterial, other drugs used in treatment, reducing their toxic systemic effect and shortening the duration of treatment.

 

Composition

 

Recombinant human Interferon alpha-2b + excipients.

 

Indications

 

Laferon is used in the complex therapy of children, adults with various diseases:

  • viral hepatitis B in moderate to severe form acute and chronic;
  • acute bacterial infections, viral and mixed;
  • septic diseases of a viral nature and bacterial, chronic and acute, including sepsis;
  • herpetic infections of different localization: multiple herpetic rashes, shingles, genital infections, keratoconjunctivitis and keratouveitis of herpetic nature;
  • Chlamydia chronic and urogenital;
  • lesions of the nervous system, accompanied by poly- and monoradicular pain syndromes;
  • papillomatosis of the larynx;
  • multiple sclerosis;
  • malignant tumors: myeloma, melanoma of the eyes and skin, cancer of the kidney, breast, bladder, Kaposi's sarcoma;
  • hemoblastoses: hairy cell, chronic myeloid leukemia, malignant non-Hodgkin's lymphoma.

 

Forms of release

 

Lyophilizate in vials for the preparation of a solution of drops in the nose (FarmBiotek nasal) + sterile dropper for drug administration.

 

Lyophilizate in vials for intramuscular and intravenous administration (injections in ampoules for injections).

 

Instructions for use and how to use them

 

The Laferon solution is administered intramuscularly, intravenously, subcutaneously, intraperitoneally, intravesically, endolymphically, parabulbarically, intranasally, rectally. To dissolve water is used for injection, if the volume of 1 ml dissolves, for dissolution in a larger volume - saline.

 

Nasal drops

 

The bottle with the dry powder of the drug should be opened and filled with boiled water to room temperature (15-25 degrees Celsius). The upper liquid level should be 1.0 cm below the vial opening. The bottle should be carefully closed with a rubber stopper and careful oscillatory movements to ensure complete dissolution of the powder. Replace the rubber stopper with the attached dropper cap. The drops are ready for use.After each use of the drug, the dropper should be covered with a protective cap.

 

To treat influenza and other acute respiratory viral infections, Laferon PharmBiothe Nasal drops are buried in the nose every 2 hours in such doses:

  • infants - 2 drops 8 times a day;
  • children aged 1-7 years - 4-6 drops 8 times a day;
  • children older than 7 years - 8 drops 8 times a day;
  • adults - 10-12 drops 8-10 times a day.

 

Typically, the course of antiviral treatment with Laferon PharmBiothe Nasalny is 3-5 days. For the purpose of prophylaxis, a medicine is administered 4 drops 4 times a day.

 

Injection and other forms

 

Hepatitis B: administered intramuscularly with acute 1000000 IU for 10 days a day twice, for chronic 3000000-4000000 IU about 2 months three times a week.

 

SARS: Laferon is administered intranasally for children of 20-100 thousand IU / ml. You can enter into the nasal passages moistened with a solution of cotton turuns. The adult drug is administered intramuscularly for 3 weeks at 1,000,000-3,000,000 IU, and it can also be administered intranasally 6-8 times a day for 4 or 6 drops.

 

Pneumonia acute and recurrent viral-bacterial and viral etiology: injected intramuscularly 1,000,000 IU 5-7 days in combination with complex treatment.

 

Diarrheal syndrome of newborns: the drug is injected rectally 3-7 days in the form of microclysters of 100 thousand IU.

 

Acute intestinal infections with hypocoagulation in children: Laferon is administered rectally with 10,000 IU / kg of body thrice, with an interval of 2 days.

 

Purulent-septic diseases of the abdominal cavity: Laferon is administered intravenously 2000000-4000000 IU per day 1 time with a total dose of 12000000-16000000 IU.

 

Herpetic infections: with shingles, the drug is injected daily subcutaneously around the rash area of ​​2,000,000 IU per 5 mg of saline and intramuscularly 1,000,000 IU for 5-7 days. With cutaneous herpetic rashes, 2,000,000 IU is administered subcutaneously around the outbreak. With genital infection daily intramuscularly injected 2,000,000 IU of Laferon and application of the drug on the area of ​​the rash. With herpetic keratoconjunctivitis, 2-3 drops are injected under the conjunctiva of the eye every 2 hours 7-10 days 1,000,000 IU diluted in 5 ml of physiological saline.

 

Disorders of the nervous system, accompanied by poly- and monoradicular pain syndromes: intramuscular injection of 1000000 IU with complex treatment of 5-10 days.

 

Laryngeal papillomatosis: intramuscular or perifocal administration to the larynx 100-150 thousand IU / kg body weight 20-25 days daily.

 

Multiple sclerosis: intramuscular injection of 1000000 IU of Laferon three times a day for 10-15 days, then once a week 1,000,000 IU for half a year.

 

Malignant tumors. With melanoma of the skin, breast cancer, Kaposi's sarcoma and myeloma, 10,000 days are administered per day. With kidney cancer intramuscular injection 1000000 IU 10 days. When ureal melanoma is daily parabulbar for 10 days, 1000000 IU is administered. In bladder cancer, intravesical instillations of 5000000-10000000 IU are produced 3 to 6 times. The course is 30000000 IU. In ovarian cancer during the operation, intraperitoneally, within 5 days after the operation, 5000000 IU is introduced into the drainage. Then intramuscularly 10 days to 3,000,000 IU between courses of chemotherapy. The total dose of the drug is 90000000 IU.

 

Side effect

  • flu-like syndrome with increased body temperature, muscle and headache, chills, lethargy, joint pain;
  • long courses of treatment can be accompanied by thrombocytopenia, leukopenia, which are eliminated by reducing the dose.

 

Short courses of treatment with Laferon PharmBiothe Nasal in the form of drops in the nose do not cause any side effects.

 

Contraindications

  • allergy to interferon and excipients of the drug.

 

Application in pregnancy and lactation

 

Laferon is not prescribed during pregnancy due to the threat of interruption.The use of lactation is not known.

 

Use in children

 

Possible use in children (including infants and newborns) according to the indications and in the age-related dosages indicated above.

 

special instructions

 

At a temperature of 2-8 degrees Celsius, the vial with the prepared solution can be stored for 5 days in the refrigerator or for 2 days at room temperature (15-25 degrees). Prepared solution should be protected from direct sunlight.

 

To maintain the immunobiological activity of the drug to dissolve the powder, it is necessary to use only water cooled to room temperature of 15-25 degrees Celsius.

 

Drug Interactions

 

It is not recommended to take Laferon with glucocorticosteroids. Simultaneous reception with other medications is not contraindicated.

 

Interferon alfa-2b is able to reduce the activity of P-450 cytochromes and, consequently, affect the metabolism of cimetidine, phenytoin, curantyl, theophylline, diazepam, propranolol, warfarin, and some cytostatics. As a result, the neurotoxic, myelotoxic or cardiotoxic effects of these drugs may be enhanced.

 

With caution should be used simultaneously with narcotic, hypnotics and sedatives.

 

Interferons can affect oxidative metabolic processes. This should be taken into account when used simultaneously with drugs metabolized by oxidation (including xanthine derivatives - Aminophylline and Teofillin). When used simultaneously with Teofillinum it is necessary to monitor the concentration of the latter in the serum and, if necessary, adjust the dosage regimen.

 

Drinking alcohol during treatment is not recommended.

 

There are no data on negative interactions with complex therapy.

 

Analogues of Laferon

 

Structural analogs for the active substance:

  • Altevir;
  • Alfaron;
  • Viferon;
  • Grippferon;
  • Interferal;
  • Interferon alfa-2b is a human recombinant;
  • Intron A;
  • Layfferon;
  • Laferon PharmBiotek Nasal;
  • Realdiron;
  • EU Reaferon;
  • Reaferon Lipint.

 

Analogues for the pharmacological group (interferons):

  • Avonex;
  • Algeron;
  • Altevir;
  • Alfaron;
  • Alfaferon;
  • Betaferon;
  • Vagiphereon;
  • Viferon;
  • Wallferon;
  • Genfaxon;
  • Genferon;
  • Genferon Light;
  • Herpferon;
  • Hyaferon;
  • Grippferon;
  • Ingaron;
  • Inter;
  • Interferal;
  • Interferon beta 1b human recombinant;
  • Interferon beta 1a human recombinant;
  • Interferon leukocyte human;
  • Intron A;
  • Infagel;
  • Inferon;
  • Infibet;
  • Kipferon;
  • Layfferon;
  • Lokferon;
  • Ophthalmoferon;
  • PegAtlevir;
  • Pegasys;
  • Pegylated interferon alfa-2b;
  • PegIntron;
  • Peginterferon alfa-2b;
  • Realdiron;
  • Reaferon EU Lipint;
  • Rebif;
  • Ronbetal;
  • Roferon A;
  • SynnoWex;
  • Extavia.

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