Flamadex - instructions for use, reviews, analogs and forms of release (tablets 25 mg, injections in injections) anti-inflammatory drug for the treatment of arthritis, arthrosis, menstruation in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Flamadex. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Flamadex in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Flamadex analogs in the presence of existing structural analogues.Use for the treatment of pain and inflammation in arthritis, arthrosis, menstruation in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Flamadex non-steroidal anti-inflammatory drug (NSAID). Has anti-inflammatory, analgesic and antipyretic effect. The mechanism of action is based on inhibition of the synthesis of prostaglandins due to COX suppression.

Analgesic effect occurs 30 minutes after taking, the duration of the action is 4-6 hours.

Composition

Dexketoprofenum trometamol + auxiliary substances.

Pharmacokinetics

After taking the drug inside Cmax dexketoprofen in humans is achieved on average after 30 minutes (15-60 minutes). Binding to plasma proteins - 99%. Exposed to metabolism. It is excreted mainly by the kidneys in the form of metabolites.

Indications

• relief of pain syndrome of various genesis (including postoperative, post traumatic pain, pain in metastases in the bone, renal colic, algodismenore (pain during menstruation), sciatica, radiculitis, neuralgia, toothache);
• symptomatic treatment of acute and chronic inflammatory, inflammatory-degenerative and metabolic diseases of the musculoskeletal system (incl.rheumatoid arthritis, osteoarthrosis, spondyloarthritis: ankylosing spondylitis, reactive arthritis, psoriatic arthritis).

Forms of release

The tablets covered with a cover of 25 mg.

Solution for intravenous and intramuscular injection (injections in ampoules for injection 2 ml).

Instructions for use and dosing regimen

Pills

Is taken internally. The average recommended single dose is 12.5 mg - 1-6 times a day every 4-6 hours as needed or 25 mg 1-3 times a day every 8 hours.

The maximum daily dose is 75 mg. Duration of application - no more than 3-5 days.

For patients with impaired liver or kidney function, elderly patients, the initial dose is not more than 50 mg per day.

Ampoules

Intramuscularly and intravenously. The dosage regimen is set individually, depending on the type and intensity of the pain. The maximum dose is 75 mg per day; elderly, patients with impaired liver or kidney function - not more than 50 mg per day.

Flamadex is not prescribed for long-term therapy. The course of treatment with the drug should not exceed 3-5 days.

Side effect

• headache;
• dizziness;
• insomnia;
• drowsiness;
• paresthesia;
• noise in ears;
• blurred vision;
• feeling of heat;
• hyperemia of the skin;
• extrasystole;
• increased blood pressure;
• tachycardia;
• a decrease in blood pressure;
• bronchospasm;
• dyspnea;
• nausea, vomiting;
• abdominal pain;
• dyspepsia;
• diarrhea, constipation;
• dry mouth;
• flatulence;
• erosive and ulcerative lesions of the gastrointestinal tract;
• bleeding from the ulcer or perforation;
• anorexia;
• defeat of the pancreas;
• increased activity of hepatic enzymes, incl. AST and ALT, jaundice;
• liver damage;
• polyuria;
• nephritis or nephrotic syndrome;
• menstrual cycle disorders in women;
• with prolonged use, transient abnormalities of the prostate gland function in men;
• backache;
• muscular spasm;
• difficulty in movement in the joints;
• dermatitis;
• rash;
• hives;
• acne;
• sweating;
• severe skin reactions (Stevens-Johnson syndrome, Lyell's syndrome);
• angioedema;
• allergic dermatitis;
• photosensitization;
• Hyperglycemia, hypoglycemia, hypertriglyceridemia;
• ketonuria, proteinuria;
• fever;
• fatigue;
• anaphylactic shock;
• swelling of the face;
• aseptic meningitis, which occurs predominantly in patients with systemic lupus erythematosus or mixed connective tissue diseases;
• hematological disorders (purpura, aplastic and hemolytic anemia);
• neutropenia, thrombocytopenia;
• bone marrow hypoplasia.

Contraindications

• hypersensitivity to dexketoprofen or other NSAIDs, or any of the excipients that make up the drug;
• complete or incomplete combination of bronchial asthma, recurrent nasal polyposis and paranasal sinuses and intolerance to acetylsalicylic acid or other NSAIDs (in the anamnesis);
• erosive and ulcerative lesions of the gastrointestinal tract and duodenal ulcer in the stage of exacerbation;
• gastrointestinal hemorrhages in anamnesis, other active bleeding (including suspicion of intracranial bleeding), anticoagulant therapy;
• inflammatory bowel disease (ulcerative colitis, Crohn's disease) in the stage of exacerbation;
• severe violations of the liver (10-15 points on the scale Child-Pugh);
• moderate or severe renal dysfunction (creatinine clearance less than 30 ml / min);
• confirmed hyperkalemia;
• Decompensated heart failure;
• period after aortocoronary shunting;
• hemophilia and other disorders of blood clotting;
• progressive kidney disease;
• pregnancy;
• the period of breastfeeding;
• Children under 18 years of age (there are no clinical data on the effectiveness and safety of the drug in pediatric practice).

Application in pregnancy and lactation

The use of Flamadex during pregnancy and during lactation is contraindicated.

Application in elderly patients

Care should be taken when prescribing the drug to elderly patients. For the elderly, the initial dose is not more than 50 mg per day.

Use in children

Contraindicated in children and adolescents under the age of 18 years (no clinical data on the efficacy and safety of the drug in pediatric practice).

special instructions

Care should be taken when prescribing the drug to elderly patients, patients with allergic reactions, systemic connective tissue diseases and patients with hematopoiesis.

Patients should be informed that if side effects occur, and if there is no clinical effect within 3-5 days of treatment, it is necessary to inform the attending physician about it.

Special care is required with the simultaneous use of dexketoprofen with phenytoin, sulfonamides and drugs that reduce blood clotting.

Not intended for long-term treatment.

Impact on the ability to drive vehicles and manage mechanisms

Since Flamadex can cause a decrease in the ability to concentrate, it should be used with caution in patients engaged in potentially hazardous activities requiring increased attention and speed of psychomotor reactions.

Drug Interactions

With the simultaneous use of Flamadex with other NSAIDs, an increased risk of side effects may occur.

With simultaneous use with lithium preparations, an increase in the concentration of the latter in the blood plasma is possible.

Be wary of using dexketoprofen in less than 24 hours before or after the end of Methotrexate therapy, since the concentration of the latter in the blood plasma (and, consequently, toxicity) may increase.

Individual cases of bleeding are described with simultaneous application of NSAIDs and anticoagulants.

Analogues of the drug Flamadex

Structural analogs for the active substance:

• Dexalgin;
• Dexketoprofen;
• Dexketoprofen trometamol;
• Ketodexal.

Analogues for the pharmacological group (non-steroidal anti-inflammatory drugs, derivatives of propionic acid):

• Advance;
• Advil for children;
• Ultrazir Ultra;
• Apranaks;
• Arketal Rompharm;
• Arthrosylen;
• Artrum;
• Bonifen;
• Brustan;
• Brufen;
• Brufen retard;
• Bystrumgel;
• Vimovo;
• Dolgit;
• Ibuklin;
• Ibuprofen;
• Ibusan;
• Ibufen;
• Ketonal;
• Ketoprofen;
• Ketosphere;
• MIG 200, 400;
• Nalgezin;
• Nalgezin forte;
• Naprobeene;
• Naproxen;
• Next;
• Novigan;
• Nurofen;
• Oruvel;
• Pedee;
• Pentalgin;
• Pronaxen;
• Profenide;
• Sanaprox;
• Solpaflex;
• Spasgan Neo;
• Surgham;
• Faspik;
• Fastum gel;
• Febrofide;
• Flamax;
• Flamax forte;
• Fleksen;
• Flugalin;
• Hyrumat.

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