Fenotropil - instructions for use, analogs, reviews and release forms (tablets 50 mg and 100 mg) drugs for the treatment of depression, seizures and other diseases of the nervous system in adults, children and pregnancy
In this article, you can read the instructions for using the drug Phenotropil. Comments of visitors of the site - consumers of this medication, as well as opinions of physicians specialists on the use of Fentropil in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of phenothropyl in the presence of existing structural analogues. Use for the treatment of depression, seizures, alcoholism and other diseases of the central nervous system in adults, children, as well as during pregnancy and lactation.
Phenotropil - Nootropic preparation.Has a pronounced antiamnestic effect, activates the integrative activity of the brain, promotes memory consolidation, improves concentration and mental activity, facilitates learning processes, accelerates the transfer of information between the cerebral hemispheres, increases the resistance of brain tissue to hypoxia and toxic effects, has anticonvulsant action and anxiolytic activity , regulates the processes of activation and inhibition of the central nervous system, improves mood.
Fenotropil has a positive effect on the metabolic processes and blood circulation of the brain, stimulates redox processes, increases the energy potential of the body through the utilization of glucose, improves regional blood flow in the ischemic areas of the brain. Increases the content of norepinephrine, dopamine and serotonin in the brain.
Phenotropil has no effect on respiratory and cardiovascular systems. Has a weakly diuretic effect. Possesses anorexigenic activity in course use.
Phenotropil has a moderately activating effect on motor reactions, improves physical performance, has a pronounced antagonism with respect to the catalepsy effect of neuroleptics, reduces the expression of the hypnotic effect of ethanol (alcohol) and hexenal.
Psycho-stimulating effect of phenothropylate predominates in the ideator sphere. Moderate psychoactivating effect of the drug is combined with anxiolytic activity. Phenotropil improves mood, analgesic effect, raising the threshold of pain sensitivity.
Fenotropil has an adaptogenic effect, increasing the body's resistance to stress in conditions of increased mental and physical loads, fatigue, hypokinesia and immobilization, at low temperatures.
Against the background of the use of Fenotropil noted improvement in vision (increased acuity, brightness and fields of vision).
Phenotropil improves the blood supply of the lower extremities.
Phenotropol stimulates the production of antibodies in response to the administration of the antigen, which indicates its immunostimulating properties, but at the same time does not cause the development of immediate-type hypersensitivity reactions and does not change the allergic inflammatory reaction of the skin,caused by the introduction of a foreign protein.
In the course of the use of Fenotropil, drug dependence and tolerance do not develop. When the drug was withdrawn, there was no development of withdrawal syndrome.
The action of Fenotropil appears after a single dose, which is important when using the drug in extreme conditions.
Pharmacokinetics
After oral administration, it is rapidly absorbed from the digestive tract, distributed in various organs and tissues, easily penetrates the GEB. Absolute bioavailability of the drug when taken inside is 100%. Phenylpyracetam is not metabolized in the body and is excreted unchanged. About 40% is excreted in the urine, 60% - with bile and then.
Indications
- diseases of the central nervous system of various genesis, especially diseases of vascular genesis or associated with impaired metabolic processes in the brain and intoxication (in particular, in posttraumatic states and chronic cerebrovascular insufficiency), accompanied by impaired intellectual and mnestic functions, decreased motor activity;
- neurotic states, manifested sluggishness, increased exhaustion, decreased psychomotor activity, violation of attention, memory impairment;
- violation of learning processes;
- depression of mild and moderate severity;
- psycho-organic syndromes, manifested by intellectual-mnestic disorders and apatiko-abulic symptoms, as well as flaccid states in schizophrenia;
- convulsive conditions;
- obesity (alimentary-constitutional genesis);
- prevention of hypoxia, increased resistance to stress;
- correction of a functional state of an organism in extreme conditions of professional activity with the purpose of the prevention of development of fatigue and increase of mental and physical working capacity;
- correction of daily biorhythm, regulation of the "sleep-wake" cycle;
- chronic alcoholism (with the aim of reducing the symptoms of asthenia, depression, and intellectual-mnestic disorders).
Forms of release
Tablets of 50 mg and 100 mg.
Instructions for use and dosage
The dosage regimen is set individually.
Phenotropol is taken orally right after eating.
The average single dose is 100-200 mg, the average daily dose is 200-300 mg. The maximum daily dose is 750 mg. It is recommended to divide the daily dose into 2 doses. The daily dose to 100 mg should be taken 1 time per day in the morning, a daily dose of more than 100 mg should be divided into 2 divided doses.Duration of treatment can vary from 2 weeks to 3 months. The average duration of treatment is 30 days. If necessary, the course can be repeated in a month.
To improve performance, 100-200 mg once a day in the morning for 2 weeks (for athletes - 3 days).
With alimentary-constitutional obesity - 100-200 mg once a day in the morning for 30-60 days.
It is not recommended to take Phenotropol after 15 hours.
Side effect
- insomnia (when taking the drug after 15 hours);
- psychomotor agitation;
- hyperemia of the skin;
- sensation of heat;
- increased blood pressure.
Contraindications
- hypersensitivity to the components of the drug.
Application in pregnancy and lactation
Fentotropil should not be prescribed during pregnancy and lactation (breastfeeding) because of the lack of data from clinical studies.
Phenotropil does not have teratogenic, mutagenic and embryotoxic effects.
special instructions
It should be borne in mind that with excessive psychoemotional exhaustion on the background of chronic stress and fatigue, chronic insomnia, a single dose of Fentropil in the first day can cause a sharp need for sleep.Such patients in outpatient settings are advised to start taking the drug on non-working days.
Use in Pediatrics
Fentotropil is not recommended for children due to the lack of clinical data on the use of the drug in children.
Results of experimental studies
Fenotropil is characterized by low toxicity, the lethal dose in an acute experiment is 800 mg / kg. Does not have a carcinogenic effect.
Drug Interactions
Fenotropil can enhance the effect of drugs that stimulate the central nervous system, antidepressants and nootropic drugs.
Analogues of the drug Fentotropil
Structural analogues for the active substance of the drug Fenotropil has no. However, there is a large class of drugs nootropics with similar therapeutic effects:
- Amylonosar;
- Aminalon;
- Ampasse;
- Anvifen;
- Bilobil;
- Vitrum Memori;
- Gamma-aminobutyric acid;
- Gamalon;
- Gingiium;
- Ginkyo;
- Ginkoum;
- Ginos;
- Glaser;
- Gliatilin;
- Glycerylphosphorylcholine hydrate;
- Glycine;
- Glutamic acid;
- Gopantam;
- Hopantenic acid;
- Delecite;
- Demanol;
- Idebenon;
- Intelland;
- Cortexin;
- Lucetsam;
- Meclofenoxate hydrochloride;
- Mexiprim;
- Mexicin;
- Memotropized;
- Metaproth;
- Minisem;
- Neuromet;
- Noben;
- Noctellin;
- Hoenopt;
- Nootebril;
- Nootropil;
- Noocetam;
- Pantogam;
- Pantokaltsin;
- Pikamilon;
- Piraben;
- Pyramids;
- Pyramidal;
- Piracetam;
- Pyriditol;
- Pramistar;
- Semax;
- Stamine;
- Tenoten;
- Fenibut;
- Holilitil;
- Cebrilysin;
- Ceraxon;
- Cerebramine;
- Cerebrial;
- Cerebrosolate;
- Cerebrolysin;
- Cereton;
- Cerutil;
- Energol;
- Encephabol;
- The escotrope.
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