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Finasteride - instructions for use, reviews, analogs and formulations (5 mg Teva tablets, OBL) for the treatment of benign prostatic hyperplasia (BPH) and improving urine flow in men. Composition

Finasteride - instructions for use, reviews, analogs and formulations (5 mg Teva tablets, OBL) for the treatment of benign prostatic hyperplasia (BPH) and improving urine flow in men. Composition

In this article, you can read the instructions for using the drug Finasteride. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of physicians specialists on the use of Finasteride in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Finasteride analogs in the presence of existing structural analogs. Use to treat benign prostatic hyperplasia (BPH) and improve urine flow in men. Composition of the preparation.

 

Finasteride - inhibitor of 5-alpha reductase - an enzyme that converts testosterone into a more active dihydrotestosterone. Reduces the content of dihydrotestosterone in the blood and tissues of the prostate gland. Oppressing the stimulating effect of dihydrotestosterone on the development of prostatic adenoma.

 

Finasteride helps reduce the size of the enlarged gland, improves urine flow and reduces symptoms associated with benign prostatic hypertrophy. To reduce the clinical manifestations of the disease may take several months of treatment.

 

Composition

 

Finasteride + auxiliary substances.

 

Pharmacokinetics

 

Well absorbed and penetrates into the tissues and body fluids, is found in the ejaculate. Bioavailability is 80% and does not depend on food intake. The connection with plasma proteins is 90%. It is excreted as metabolites by the kidneys (39%) and through the intestine (57%). Long-term (3-7 months) reception at a dose of 5 mg per day reduces the concentration of 5-alpha-dihydrotestosterone in serum by 70%.

 

Indications

  • benign prostatic hyperplasia (with the purpose of reducing the size of the prostate gland, improving the urine flow and reducing symptoms,associated with hyperplasia; reducing the risk of acute urinary retention requiring catheterization or surgery, including transurethral resection of the prostate and prostatectomy).

 

Forms of release

 

The tablets covered with a cover of 5 mg.

 

Instructions for use and dosage

 

Inside, 5 mg once a day, regardless of food intake.

 

The duration of therapy before evaluating its effectiveness should be at least 6 months, so the course of treatment should be quite long. Finasteride can be used in the form of monotherapy, as well as in combination with doxazosin.

 

Side effect

  • impotence;
  • decreased libido;
  • decrease in ejaculate volume;
  • gynecomastia;
  • skin rash;
  • angioedema.

 

Contraindications

  • hypersensitivity to finasteride;
  • obstructive uropathy;
  • prostate cancer;
  • finasteride is not used in women and children.

 

Application in pregnancy and lactation

 

Women of childbearing age and pregnant women should avoid contact with the drug Finasteride, tk. it has teratogenic properties (the ability to suppress the conversion of testosterone to dihydrotestosterone can cause a disruption in the development of sexualorgans in a male fetus) penetrates into the seminal fluid.

 

Use in children

 

The drug is not used in children.

 

special instructions

 

With caution appoint finasteride with hepatic insufficiency.

 

With a large volume of residual urine and / or a sharply reduced urine flow, one must keep in mind the development of obstructive uropathy.

 

Before the start of treatment with finasteride and periodically during the treatment should be carried out rectal examination, as well as research by other methods for the presence of prostate cancer.

 

Drug Interactions

 

There was no clinically significant interaction of finasteride with propranolol, digoxin, glyburide, warfarin, theophylline and antipyrin.

 

It seems that finasteride does not significantly affect the enzymatic system of cytochrome P450 and, accordingly, does not affect the pharmacokinetic indices of drugs metabolized by microsomal liver enzymes.

 

With simultaneous application of finasteride with ACE inhibitors, alpha-adrenoblockers, beta-blockers, calcium channel blockers, nitrates, diuretics, histamine H2-receptor blockers, HMG-CoA reductase inhibitors,non-steroidal anti-inflammatory drugs (NSAIDs), quinolones and benzodiazepines, there was no clinically significant drug interaction.

 

Analogues of Finasteride

 

Structural analogs for the active substance:

  • Alfinal;
  • Grain;
  • Penester;
  • Proscar;
  • Prosteride;
  • Urofin;
  • Finast;
  • Finasteride OBL;
  • Finasteride Teva;
  • Finpros.

 

Analogues on the curative effect (remedies for the treatment of benign prostatic hyperplasia):

  • Avodart;
  • Adenostop;
  • Artesine;
  • Afala;
  • Vezielut;
  • Viardot;
  • Vitaprost;
  • Vitaprost forte;
  • Gentos;
  • Glansin;
  • Dalfaz;
  • Dalfaz retard;
  • Depostat;
  • Doxazosin;
  • Dutasteride;
  • Indigalplus;
  • Indigal;
  • Ipertrophane 40;
  • Camyrin;
  • Cardura;
  • Kornam;
  • Lycoprophyte;
  • Longidase;
  • Metovit;
  • Nitroxoline;
  • Omnik;
  • Omnik Okas;
  • Omsulosin;
  • Permikson;
  • Polipressin;
  • Populus composite;
  • Simple String;
  • Prostavern Urtika;
  • They will prostate;
  • Prostagut forte;
  • Prostamine;
  • Prostamol Uno;
  • Prostaplant;
  • Simpletons;
  • Raveron;
  • Serpens;
  • Setegis;
  • Cialis;
  • Sinestrol;
  • Sonizine;
  • Spem;
  • Tadenan;
  • Tamsulon FS;
  • Tonicardin;
  • Trianol;
  • Tulosin;
  • Tyqveol;
  • Urorek;
  • Focussin;
  • Haytrin;
  • Cernilton;
  • Cernilton forte.

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