Anvifen - instructions for use, analogs, reviews and release forms (capsules or tablets 25 mg, 50 mg, 125 mg and 250 mg) of the drug for stuttering, tics, enuresis and neuroses in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Anvifen. Presented are reviews of visitors to the site - consumers of this medication, as well as the opinions of the doctors of specialists on the use of Anvifen in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues Anvifen in the presence of existing structural analogues. Use to treat stuttering, tics, enuresis and neuroses in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Anvifen - Nootropic drug, facilitates GABA-mediated transmission of nerve impulses to the central nervous system (direct effect on GABA-ergic receptors). The tranquilizing effect is combined with the activating effect. It also has antiplatelet, antioxidant and some anticonvulsant action.

Improves the functional state of the brain due to the normalization of its metabolism and influence on the cerebral blood flow (increases volumetric and linear speed, reduces vascular resistance, improves microcirculation, and has antiaggregant effect). It prolongs the latent period and shortens the duration and severity of nystagmus.

Does not affect cholino- and adrenergic receptors. Reduces vasovegetative symptoms (including headache, sensation of heaviness in the head, sleep disorders, irritability, emotional lability). At the course reception increases physical and mental efficiency (attention, memory, speed and accuracy of sensory-motor reactions).

Reduces the manifestation of asthenia (improves well-being, increases interest and initiative (motivation of activity)) without sedation or arousal. Helps reduce feelings of anxiety, tension and anxiety, normalizes sleep.

People of advanced age do not cause CNS depression, muscular-relaxing aftereffect is most often absent.

Composition

Aminophenylbutyric acid hydrochloride + excipients.

Pharmacokinetics

Absorption is high, it penetrates well into all tissues of the body and through the blood-brain barrier or GEB (in the brain tissue penetrates about 0.1% of the administered dose of the drug, and in young and old people to a much greater extent). Evenly distributed in the liver and kidneys. Metabolized in the liver - 80-95%, metabolites are not pharmacologically active. Do not cumulate. After 3 hours begins to be excreted by the kidneys, while the concentration in the brain tissue does not decrease and is detected for another 6 hours. About 5% is excreted by the kidneys unchanged, partly with bile.

Indications

• asthenic and anxiety-neurotic states;
• stuttering, tics and enuresis in children;
• insomnia and nighttime anxiety in elderly patients;
• Meniere's disease, dizziness associated with dysfunction of the vestibular analyzer of various genesis;
• prevention of motion sickness and dizziness in kinetosis;
• in the complex therapy of alcohol withdrawal syndrome for the relief of psychopathological andsomatovegetative disorders.

Forms of release

Capsules 25 mg, 50 mg, 125 mg and 250 mg (sometimes mistakenly called tablets).

Instructions for use and dosing regimen

Inside after eating 2-3-week courses.

Adults and children from 14 years of 250-500 mg 3 times a day (maximum daily dose of 2500 mg). Children from 3 to 8 years of 50-100 mg 3 times a day; from 8 to 14 years - 250 mg 3 times a day.

A single maximum dose in adults and children from 14 years is 750 mg, in patients older than 60 years - 500 mg, in children under 8 years - 150 mg, from 8 to 14 years - 250 mg.

With alcohol withdrawal syndrome - 250-500 mg 3 times a day and at night - 750 mg, with a gradual decrease in the daily dose to the usual for adults.

For treatment of dizziness with dysfunctions of the vestibular apparatus and Meniere's disease - 250 mg 3 times a day for 14 days.

For the prevention of motion sickness - 250-500 mg once for 1 hour before the expected start of the rolling or when the first symptoms of seasickness appear. Anti-sweating action of the drug Anvifen increases with increasing dose of the drug. At the onset of severe manifestations of seasickness (vomiting, etc.), the administration of the drug Anvifen is ineffective even in doses of 750-1000 mg.

Side effect

• drowsiness;
• nausea;
• increased irritability;
• excitation;
• anxiety;
• dizziness;
• headache (at the first reception);
• allergic reactions.

Contraindications

• pregnancy;
• breast-feeding;
• children under 3 years;
• hypersensitivity.

Application in pregnancy and lactation

The drug Anvifen is contraindicated for use in pregnancy and lactation (breastfeeding).

Use in children

Contraindicated in children under 3 years of age.

Application in elderly patients

A single maximum dose in patients older than 60 years is 500 mg.

special instructions

With prolonged use, it is necessary to periodically monitor the performance of the liver and peripheral blood.

With caution should apply the drug Anvifen with erosive-ulcerative lesions of the gastrointestinal tract, liver failure.

Impact on the ability to drive vehicles and manage mechanisms

It is necessary to refrain from potentially dangerous activities requiring increased concentration of attention.

Drug Interactions

Extends and enhances the effect of hypnotics, narcotic analgesics, neuroleptics, antiparkinsonian and antiepileptic drugs.

Analogues of the drug Anvifen

Structural analogs for the active substance:

• Aminophenylbutyric acid;
• Noophen;
• Phenibut.

Analogues for the pharmacological group (nootropics):

• Amylonosar;
• Aminalon;
• Astrox;
• Bilobil;
• Vinpotropil;
• Gamalon;
• Ginkyo;
• Gliatilin;
• Glycine;
• Gopantam;
• Idebenon;
• Cortexin;
• Lucetsam;
• Mexiprim;
• Mexicin;
• Memotropized;
• Noben;
• Hoenopt;
• Nootropil;
• Noophen;
• Noocetam;
• Omaron;
• Pantogam;
• Pantokaltsin;
• Pikamilon;
• Piraben;
• Piracesine;
• Piracetam;
• Semax;
• Stamine;
• Tenoten;
• Tenoten for children;
• Thiocetam;
• Fezam;
• Fenibut;
• Phenotropil;
• Fescetam;
• Choline alphoscerate;
• Holilitil;
• Cebrilysin;
• Celestab;
• Ceraxon;
• Cerebrosolate;
• Cerebrolysin;
• Cerepro;
• Cereton;
• Energol;
• Encephabol;
• The escotrope.

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