Nicotinic acid or Niacin - instructions for use, analogs, reviews and release forms (50 mg tablets, injectable injections) for the treatment of vitamin B3 or PP deficiency, hair loss in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Nicotinic acid or Niacin. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Nicotinic acid or Niacin in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of nicotinic acid in the presence of existing structural analogues.Use to treat vitamin B3 or PP deficiency, pellagra and hair loss or baldness in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Nicotinic acid or Niacin - vitamin and hypolipidemic means. In the body, nicotinic acid is converted into nicotinamide, which binds to the coenzymes of codegyrogenase 1 and 2 (NAD and NADP), which carry hydrogen, participates in the metabolism of fats, proteins, amino acids, purines, tissue respiration, glycogenolysis, and synthetic processes.

Replenishes vitamin PP deficiency (vitamin B3), is a specific antipellagic agent (vitamin PP vitamin deficiency). Normalizes the concentration of blood lipoproteins; in high doses (inside 3-4 grams per day) reduces the concentration of total cholesterol, LDL, TG, reduces the cholesterol / phospholipids index, increases the level of HDL with anti-atherogenic effect. Has vasodilating effect at the level of small vessels (including the brain), improves microcirculation, has a weak anticoagulant effect (increases fibrinolytic activity of the blood).

Hypocholesterolemic effect is observed in a few days, decrease in TG - a few hours after admission.

Composition

Nicotinic acid + excipients.

Indications

Hypo-and avitaminosis PP:

• Pellagra (accompanied by irritability, dermatitis, insomnia, hair loss or baldness and other symptoms);
• inadequate and unbalanced nutrition (including parenteral);
• malabsorption syndrome (including on the background of pancreatic function disruption);
• rapid weight loss;
• gastrectomy;
• Hartnup disease (hereditary disease, accompanied by a violation of the assimilation of certain amino acids, including tryptophan);
• diseases of the digestive tract (gluten enteropathy, persistent diarrhea, tropical sprue, Crohn's disease).

The states of increased body requirement in the vitamin PP:

• prolonged fever;
• diseases of the hepatobiliary region (acute and chronic hepatitis, cirrhosis of the liver);
• hyperthyroidism;
• chronic infections;
• malignant tumors;
• long-term stress;
• pregnancy (especially against the background of nicotine and drug dependence, multiple pregnancies);
• lactation period.

Hyperlipidemia, incl.primary hyperlipidemia (types 2a, 2b, 3, 4, 5) and impaired cholesterol metabolism.

Ischemic disorders of cerebral circulation, obliterating diseases of the vessels of the extremities (obliterating endarteritis, Raynaud's disease), spasm of the vessels of the extremities, biliary and urinary tracts; diabetic polyneuropathy, microangiopathy.

Neuritis of the facial nerve, hypoacid gastritis, enterocolitis, colitis, long-term healing wounds and trophic ulcers.

Forms of release

Tablets 50 mg.

Solution for injections (injections in ampoules).

Instructions for use and dosing regimen

Inside (after eating), intravenously slowly, intramuscularly, subcutaneously. For prophylaxis: inside, adults - 0.0125-0.025 g per day, children - 0.005-0.025 g per day.

When pellagra and improve hair growth: adults - inside, 0.1 g 2-4 times a day for 15-20 days or intravenously at 0.05 g or intramuscularly 0.1 g, 1-2 times a day in within 10-15 days; children - inside, on 0,0125-0,05 g 2-3 times a day.

With ischemic stroke: intravenously, 0.01-0.05 g.

When atherosclerosis: inside, 2-3 grams per day in 2-4 admission.

In case of violations of lipid metabolism: inside, the dose is gradually increased (in the absence of side effects) from 0.05 g once a day to 2-3 grams per day in several doses, the course of treatment is 1 month or more, breaks are required between repeated courses.

For other diseases: inside, adults - 0,02-0,05 g (up to 0,1 g) 2-3 times a day, children - 0,0125-0,025 g 2-3 times a day.

Side effect

• hyperemia of the skin of the face and upper half of the trunk with a sensation of tingling and burning;
• with rapid administration - reduced blood pressure, orthostatic hypotension, collapse;
• paresthesia;
• dizziness;
• fatty degeneration of the liver;
• decreased glucose tolerance;
• increase in blood AST, LDG, AP;
• soreness in the place of subcutaneous and intramuscular injections;
• allergic reactions.

Contraindications

• hypersensitivity to nicotinic acid;
• peptic ulcer of the stomach and duodenum in the phase of exacerbation;
• Children under 2 years of age (as a hypolipidemic drug) (for tablets);
• severe arterial hypertension;
• atherosclerosis;
• gout;
• hyperuricemia.

Application in pregnancy and lactation

Use with caution Nicotinic acid or Niacin in pregnancy and lactation (taking high doses is contraindicated).

Use in children

Contraindicated in children under 2 years (as a hypolipidemic agent) for taking in the form of tablets.

Parenteral forms of Niacin are contraindicated for use in childhood.

special instructions

Use with caution in patients with hemorrhages, glaucoma, gout, hyperuricemia, hepatic insufficiency, arterial hypotension, hyperacid gastritis, peptic ulcer and duodenal ulcer (in remission phase).

Use with caution in parenteral in patients with hemorrhages, glaucoma, liver failure, arterial hypotension, hyperacid gastritis, peptic ulcer and duodenal ulcer (in the phase of exacerbation).

With prolonged use of nicotinic acid in high doses, it is possible to develop fatty liver infiltration.

During the treatment it is necessary to monitor the function of the liver.

It is inappropriate to use to correct dyslipidemia in patients with diabetes mellitus.

To prevent complications from the liver, it is recommended to include in the diet products rich in methionine (cottage cheese) or to use methionine, Lipoic acid and other lipotropic drugs.

It should be borne in mind that subcutaneous and intramuscular injections are painful.

Drug Interactions

Care should be taken when combining with antihypertensives, anticoagulants and acetylsalicylic acid.

Nicotinic acid reduces the toxicity of neomycin and prevents the decrease in cholesterol and HDL-induced levels that it induces.

Analogues of the drug Nicotinic acid or Niacin

Structural analogs for the active substance:

• Nicotinic acid (Niacin);
• Nicotinic acid is a bouffant;
• Nicotinic acid Vial;
• Enduracin.

Analogues for the pharmacological group (vitamins and vitamin-like drugs):

• Aevit;
• Antioxidants;
• Ascorbic acid;
• Ascorutin;
• Berroca;
• Vitagamma;
• Vitamax;
• Vitamin A;
• Vitamin B1;
• Vitamin B2;
• Vitamin B3;
• Vitamin B12;
• Vitamin C;
• Vitamin D3;
• Vitamin E;
• Vitrum;
• Calcevit;
• Calcium D3 Nycomed;
• Kaltsinov;
• Carnitine;
• Kombilipen;
• Complivit;
• Levocarnitine;
• Magnesium plus;
• Milgamma;
• Multitabs;
• Multimax;
• Neurogamma;
• Neurodiclavitis;
• Neuromultivitis;
• Niacinamide;
• Nicotinamide;
• Oxidevit;
• Octolipen;
• Oligovit;
• Perfectil;
• Pikovitz;
• Pyridoxine;
• Pregnavit;
• Pregnacea;
• Prenatal;
• Retinol;
• Riboflavin;
• Fish fat;
• Sana'a Sol;
• Selmevit;
• Special Merz sweets;
• Supradin;
• Teravit;
• Thiamin;
• Tioctacid;
• Triovit;
• Undevit;
• Folic acid;
• Centrum;
• Cyanocobalamin;
• Eikonol;
• Elevit Pronatal;
• Elkar.

Similar medicines:

Other medicines: