Sulpiride - instructions for use, reviews, analogs and forms of release (tablets and capsules 50 mg and 200 mg of Belupo, solution, injections in injections) of the drug for the treatment of depression in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Sulpiride. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Sulpiride in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Sulpiridum in the presence of existing structural analogs.Use for the treatment of depression, schizophrenia, alcohol withdrawal with delirium in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Sulpiride - atypical antipsychotic from the group of substituted benzamides.

Sulpiride has a moderate neuroleptic activity in combination with stimulating and thymoanaleptic (antidepressant) action. Neuroleptic effect is associated with antidopaminergic effect. In the central nervous system, sulpiride blocks mainly the dopaminergic receptors of the limbic system, and affects the neostriatic system insignificantly, it has an antipsychotic effect and causes an insignificant number of side effects. The peripheral action of sulpiride is based on oppression of presynaptic receptors. With an increase in the amount of dopamine in the central nervous system, the improvement in mood is associated with a decrease in the development of symptoms of depression.

The antipsychotic effect of Sulpiride is manifested in doses of more than 600 mg per day, in doses up to 600 mg per day, a stimulating and antidepressant effect predominates.

Sulpiride has no significant effect on adrenergic, cholinergic, serotonin, histamine, and gamma-aminobutyric acid receptors (GABA receptors).

In small doses Sulpiride can be used as an adjuvant in the treatment of psychosomatic diseases, in particular, it is effective in stopping the negative mental symptoms of peptic ulcer of the stomach and duodenum. In irritable bowel syndrome, Sulpirid reduces the intensity of abdominal pain and leads to an improvement in the clinical state of the patient. Low doses of Sulpiride (50-300 mg per day) are effective in dizziness, regardless of etiology. Sulpiride stimulates the secretion of prolactin and has a central antiemetic effect (oppression of the vomiting center).

Composition

Sulpiride + auxiliary substances.

Pharmacokinetics

After oral administration, the maximum plasma concentrations are reached after 3-6 hours. Bioavailability of sulpiride for oral administration is 25-35%. The binding of sulpiride to plasma proteins is less than 40%. Rapidly penetrates into all tissues of the body, faster - to the liver and kidneys, more slowly - to the brain tissue (with the bulk accumulated in the pituitary gland).Sulpiride in the human body is not metabolized and is excreted almost unchanged through the kidneys (about 95%). The half-life is 6-8 hours. Excreted in breast milk.

Indications

As a monotherapy or in combination with other psychotropic drugs:

• acute and chronic schizophrenia;
• acute delirious states;
• depression of various etiologies;
• neurotic disorders;
• dizziness of various etiologies (vertebrobasilar insufficiency, vestibular neuritis, Meniere's disease, condition after traumatic brain injury, otitis media);
• auxiliary therapy for peptic ulcer of stomach and duodenum, colitis (NUK) and irritable bowel syndrome.

Forms of release

Tablets 50 mg and 200 mg.

Capsules 50 mg and 20 mg (Belupo sulpiride).

Solution for oral administration.

Solution for intramuscular injection (injections in ampoules for injection).

Instructions for use and dosing regimen

Tablets and ampoules

Inside adults - 100-300 mg per day in 2-3 hours. If necessary, enter intramuscularly at a dose of 100-800 mg per day. Children are used in a daily dose of 5 mg / kg.

The maximum daily intake for adults is 1.6 g.

Belupo Capsules

Inside.

It is not recommended to take the drug in the afternoon (after 16 hours) due to the increase in the level of wakefulness.

The maximum recommended daily dose is 1.6 g of Sulpirid.

Acute and chronic schizophrenia, acute delirious psychosis: the initial dose of Sulpiride depends on the clinical picture of the disease and is 600-1200 mg per day, divided into several doses, supporting doses of 300-800 mg per day.

Depression: from 150-200 mg to 600 mg per day, divided into several receptions.

Dizziness: 150-200 mg per day, in severe conditions the dose can be increased to 300-400 mg per day. The duration of treatment should be at least 14 days.

Auxiliary therapy for peptic ulcer of stomach and duodenum, irritable bowel syndrome: 100-300 mg per day in one or two doses.

Solution for oral administration

Inside. Shake before use!

It is not recommended to take the drug in the afternoon (after 16 hours) due to the increase in the level of wakefulness.

The maximum daily intake for adults is 1600 mg of Sulpiride.

Acute and chronic schizophrenia, acute delirious psychosis: the initial doses of Sulpiride depend on the clinical picture of the disease and amount to 600 to 1200 mg of Sulpiride per day, divided into several receptions,maintenance doses - 300-800 mg per day.

Depression: from 150-200 mg to 600 mg per day, divided into several receptions.

Dizziness: 150-200 mg per day, in severe conditions the dose can be increased to 300-400 mg per day. The duration of treatment should be at least 14 days.

Auxiliary therapy for peptic ulcer of stomach and duodenum, irritable bowel syndrome: 100-300 mg of Sulpiride per day, in one or two doses.

Doses in patients with impaired renal function: due to the fact that Sulpiride is excreted from the body mainly through the kidneys, it is recommended to reduce the dose of Sulpirid and / or increase the interval between the administration of individual doses of the drug.

Doses for the elderly: for the elderly, the initial dose of Sulpiride should be 1 / 4-1 / 2 doses for adults.

Dosage for children: a standard dose of Sulpiridum for children older than 14 years is 3-5 mg / kg body weight.

Side effect

• hyperprolactinemia;
• galactorrhea;
• violation of the menstrual cycle;
• gynecomastia;
• impotence;
• frigidity;
• Diarrhea due to the presence of maltitol in the formulation;
• dry mouth;
• heartburn;
• nausea, vomiting;
• increased activity of transaminases and alkaline phosphatase in the blood serum;
• sedative effect;
• drowsiness;
• dizziness;
• headache;
• tremor;
• extrapyramidal syndrome;
• early and late dyskinesias;
• akathisia;
• oral automatism;
• psychomotor agitation;
• anxiety;
• irritability;
• sleep disorder;
• violation of visual acuity;
• tachycardia;
• possibly increase or decrease in blood pressure;
• development of orthostatic hypotension;
• dizziness;
• tachycardia;
• extension of the QT-interval;
• skin rash;
• itching;
• eczema;
• increased sweating;
• increase in body weight.

Contraindications

• acute poisoning with alcohol, hypnotics, analgesics;
• hypersensitivity to sulpiride or to any of the components of the drug;
• pheochromocytoma;
• epilepsy;
• hyperprolactinemia;
• patients in a state of affect and aggression, who are at risk of provoking symptoms;
• the period of breastfeeding;
• children under 14 years.

Application in pregnancy and lactation

It is not recommended to prescribe Sulpiride to pregnant women, except for cases when a doctor, evaluating the ratio of benefit and risk to the pregnant and fetus,that the use of the drug is necessary. During the treatment, the drug should stop breastfeeding.

Use in children

Contraindicated in children under the age of 14 years.

Application in elderly patients

Use the drug for the elderly with caution.

special instructions

In the case of the appearance of hyperthermia, which is one of the elements of malignant neuroleptic syndrome (CNS), the drug must be canceled until the cause of hyperthermia is clarified.

They are used with caution in patients with Parkinsonism, impaired renal function, elderly people, and children.

Precautions should be taken in appointing Sulpiride to patients with impaired renal function, since up to 95% of sulpiride is excreted through the kidneys. These patients are recommended to reduce the dose of Sulpiride.

Precautions should also be observed in the appointment of Sulpiride to patients with heart disease, blood vessels, Parkinson's disease, history of convulsive disorders and young women with irregular menstrual cycles, and elderly patients.

When prescribing a drug for patients with epilepsy, before starting treatment,preliminary clinical and electrophysiological examination, as the drug reduces the threshold of convulsive activity.

Whenever extrapyramidal disorders occur, a dose reduction or antiparkinsonian therapy is necessary.

During the treatment period, do not drink alcohol.

A sharp discontinuation of the drug may cause withdrawal symptoms.

The drug contains maltitol, so it can not be administered to patients with hereditary intolerance to fructose.

Impact on the ability to drive vehicles and manage mechanisms

During the period of treatment, one should refrain from engaging in potentially dangerous activities requiring increased attention and rapid psychomotor reactions.

Drug Interactions

Simultaneous reception of Sulpiride and drugs that depress the central nervous system (narcotic analgesics, antihistamines, barbiturates, benzodiazepines and other anxiolytics) may lead to an increased sedative effect of these drugs.

The combination of Sulpiride with alcohol can also enhance the sedative effect of alcohol.

It should avoid simultaneous prescription with levodopa due to the mutual antagonism of levodopa and sulpiride.

With simultaneous administration with lithium preparations, extrapyramidal disorders may develop.

There is an increased risk of orthostatic hypotension with simultaneous administration of Sulpiride and antihypertensive drugs. Sucralfate, antacids containing magnesium and / or aluminum, reduce bioavailability by 20-40%.

Analogues of the drug Sulpiride

Structural analogs for the active substance:

• Betamax;
• Prosulfin;
• Sulpirid Belupo;
• Eglek;
• Eglonyl.

Analogues for the pharmacological group (antipsychotics):

• Abilifay;
• Azaleptin;
• Aminazine;
• Aripiprazole;
• Barnetil;
• Betamax;
• Haloperidol;
• Droperidol;
• Zalast;
• Zilaxera;
• Ziprasidone;
• Ziprex;
• Invega;
• Quetiapine;
• Clozapine;
• Clopixol;
• Lakvel;
• Leponex;
• Leptinorm;
• Mazeptil;
• Moditen;
• Moditen depot;
• Olanzapine;
• Piportil;
• Propazine;
• Prosulfin;
• It is resilient;
• Ridonex;
• Rileptid;
• Risperidone;
• Rispolept;
• Risset;
• Senorm;
• Seroquel;
• Sonapaks;
• Terialgen;
• Thioridazine;
• Torendo;
• Trifluoperazine;
• Triftazine;
• Fluphenazine;
• Chlorpromazine hydrochloride;
• Chloroproticsen;
• Eglek;
• Eglonyl;
• Egolanza;
• Etaperazine.

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