Nicergoline - instructions for use, reviews, analogs and formulations (10 mg tablets, injections in injections) of the drug for the treatment of circulatory insufficiency, migraine, Raynaud's disease in adults, children and pregnancy. Composition
In this article, you can read the instructions for using the drug Nicergoline. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Nicergoline in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Nicergolin in the presence of existing structural analogues.Use for the treatment of circulatory insufficiency, migraine, Raynaud's disease in adults, children, as well as in pregnancy and lactation. Composition of the preparation.
Nicergoline - alpha-blocker. Improves cerebral circulation, activates brain metabolism. Reduces the resistance of blood vessels of the brain, increases arterial blood flow and the consumption of oxygen and glucose by brain tissues. Reduces the resistance of pulmonary vessels. Increases the rate of blood flow in the vessels of the upper and lower extremities, especially if there is a disturbance of blood circulation. Reduces platelet aggregation and improves hemorheological performance. Patients with hypertension can cause a gradual decrease in blood pressure.
Composition
Nicergoline + excipients.
Pharmacokinetics
After ingestion nicergoline quickly and almost completely (90-100%) is absorbed from the digestive tract. Metabolized by hydrolysis, dimethylation and glucuronization. There are 3 metabolites of nicergoline, the main of which is 6-methyl-8-beta-oxymethyl-10alpha-methoxyergoline. 70-80% of nicergoline and its metabolites are excreted by the kidneys within 70-100 h after ingestion. 20% of nicergoline is excreted with feces.
Indications
- acute and chronic insufficiency of cerebral circulation (including atherosclerosis of cerebral vessels, dynamic disorders of cerebral circulation, thrombosis and embolism of cerebral vessels, stroke);
- migraine;
- vascular dementia;
- obliterating diseases of the vessels of the extremities;
- Raynaud's disease;
- Arterial hypertension and hypertensive crisis (as an auxiliary tool).
Forms of release
The tablets covered with a cover of 10 mg.
Lyophilizate for solution for injection (injections in ampoules).
Instructions for use and dosage
Pills
Install individually. Inside - 5-10 mg 3 times a day, the course of treatment - 2-3 months or more.
Ampoules
Intramuscularly - 2-4 mg 2 times a day. Single dose for intravenous drip introduction is 4-8 mg, with intra-arterial - 4 mg.
In acute cerebrovascular disorders, ischemic stroke due to atherosclerosis, thrombosis and embolism of cerebral vessels, transient cerebral circulation disorders (transient ischemic attacks, hypertensive cerebral crises), it is preferable to begin treatment with parenteral administration of nicergoline (IM or IV), then continue taking the drug inside as maintenance therapy.
Side effect
- Orthostatic hypotension and dizziness (especially after IM or IV injection);
- fainting;
- redness of facial skin;
- sleep disorders;
- excitation;
- drowsiness;
- insomnia;
- anxiety;
- increased sweating;
- nausea;
- diarrhea;
- increased acidity of gastric juice;
- stomach ache;
- decreased appetite;
- erythema;
- hives.
Contraindications
- recently suffered acute myocardial infarction;
- acute bleeding;
- severe bradycardia;
- violation of orthostatic regulation;
- simultaneous administration of alpha and beta-blockers,
- children and adolescents under 18;
- pregnancy;
- lactation period (breastfeeding);
- increased sensitivity to nicergoline, other derivatives of ergotamine, auxiliary components of the drug.
Application in pregnancy and lactation
Nicergoline contraindicated in pregnancy and lactation (breastfeeding).
Use in children
Contraindicated in children and adolescents under the age of 18 years.
Application in elderly patients
Older patients with a serum creatinine level greater than 2 mg / dl require a correction of the dosing regimen.
special instructions
Patients with renal insufficiency and elderly patients with a serum creatinine level greater than 2 mg / dl require a correction of the dosing regimen.
After intramuscular or intravenous administration of Nicergoline, the patient should be in a horizontal position for several minutes.
With prolonged therapy, patients should be examined at least once every 6 months, with a view to possibly reducing the dose or abolishing Nicergoline.
Impact on the ability to drive vehicles and manage mechanisms
Despite the fact that Nicergoline helps to improve concentration, the effect of the drug on the ability to drive vehicles and work with mechanisms has not been specifically studied. Given the nature of the underlying disease, patients should be cautious in potentially hazardous activities.
Drug Interactions
With simultaneous use with antihypertensive drugs, antihypertensive effect is enhanced.
With simultaneous application, the effect of indirect anticoagulants and antiaggregants is intensified (possibly an increase in bleeding time).
Analogues of the drug Nicergoline
Structural analogs for the active substance:
- Nilogrin;
- Nicergoline Decaux;
- Nicergolin Ferein;
- Sermion.
Analogues on the pharmacological group (angioprotectors and microcirculatory correctors):
- Agapurin;
- Actovegin;
- Angiovitis;
- Antistaks;
- Arbiflex;
- Ascorutin;
- Asnithon;
- Aescin;
- Betaver;
- Betagistin;
- Betaserc;
- Bilobil;
- Bilobil forte;
- Vazaprostan;
- Vasoket;
- Venarus;
- Venen;
- Vestibo;
- Vestap;
- Ginkgo biloba;
- Ginkor fort;
- Detraleks;
- Diosmin;
- Dipyridamole;
- Dicycin;
- Xantinol nicotinate;
- Courantil;
- Memoplant;
- Methyl ethylpyridinol;
- A nicotinic acid;
- Oxygenyl;
- Pentylin;
- Pentohexal;
- Pentoxifylline;
- Rutin;
- Solcoseryl;
- Tagist;
- Tanakan;
- Trental;
- Troxevasin;
- Troxerutin;
- Flebodia 600;
- Phlebofa;
- Flexitale;
- Emoxipine;
- Escuzan;
- Eszizan;
- Etamsylate.
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