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Nicergoline - instructions for use, reviews, analogs and formulations (10 mg tablets, injections in injections) of the drug for the treatment of circulatory insufficiency, migraine, Raynaud's disease in adults, children and pregnancy. Composition

Nicergoline - instructions for use, reviews, analogs and formulations (10 mg tablets, injections in injections) of the drug for the treatment of circulatory insufficiency, migraine, Raynaud's disease in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Nicergoline. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Nicergoline in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Nicergolin in the presence of existing structural analogues.Use for the treatment of circulatory insufficiency, migraine, Raynaud's disease in adults, children, as well as in pregnancy and lactation. Composition of the preparation.

 

Nicergoline - alpha-blocker. Improves cerebral circulation, activates brain metabolism. Reduces the resistance of blood vessels of the brain, increases arterial blood flow and the consumption of oxygen and glucose by brain tissues. Reduces the resistance of pulmonary vessels. Increases the rate of blood flow in the vessels of the upper and lower extremities, especially if there is a disturbance of blood circulation. Reduces platelet aggregation and improves hemorheological performance. Patients with hypertension can cause a gradual decrease in blood pressure.

 

Composition

 

Nicergoline + excipients.

 

Pharmacokinetics

 

After ingestion nicergoline quickly and almost completely (90-100%) is absorbed from the digestive tract. Metabolized by hydrolysis, dimethylation and glucuronization. There are 3 metabolites of nicergoline, the main of which is 6-methyl-8-beta-oxymethyl-10alpha-methoxyergoline. 70-80% of nicergoline and its metabolites are excreted by the kidneys within 70-100 h after ingestion. 20% of nicergoline is excreted with feces.

 

Indications

  • acute and chronic insufficiency of cerebral circulation (including atherosclerosis of cerebral vessels, dynamic disorders of cerebral circulation, thrombosis and embolism of cerebral vessels, stroke);
  • migraine;
  • vascular dementia;
  • obliterating diseases of the vessels of the extremities;
  • Raynaud's disease;
  • Arterial hypertension and hypertensive crisis (as an auxiliary tool).

 

Forms of release

 

The tablets covered with a cover of 10 mg.

 

Lyophilizate for solution for injection (injections in ampoules).

 

Instructions for use and dosage

 

Pills

 

Install individually. Inside - 5-10 mg 3 times a day, the course of treatment - 2-3 months or more.

 

Ampoules

 

Intramuscularly - 2-4 mg 2 times a day. Single dose for intravenous drip introduction is 4-8 mg, with intra-arterial - 4 mg.

 

In acute cerebrovascular disorders, ischemic stroke due to atherosclerosis, thrombosis and embolism of cerebral vessels, transient cerebral circulation disorders (transient ischemic attacks, hypertensive cerebral crises), it is preferable to begin treatment with parenteral administration of nicergoline (IM or IV), then continue taking the drug inside as maintenance therapy.

 

Side effect

  • Orthostatic hypotension and dizziness (especially after IM or IV injection);
  • fainting;
  • redness of facial skin;
  • sleep disorders;
  • excitation;
  • drowsiness;
  • insomnia;
  • anxiety;
  • increased sweating;
  • nausea;
  • diarrhea;
  • increased acidity of gastric juice;
  • stomach ache;
  • decreased appetite;
  • erythema;
  • hives.

 

Contraindications

  • recently suffered acute myocardial infarction;
  • acute bleeding;
  • severe bradycardia;
  • violation of orthostatic regulation;
  • simultaneous administration of alpha and beta-blockers,
  • children and adolescents under 18;
  • pregnancy;
  • lactation period (breastfeeding);
  • increased sensitivity to nicergoline, other derivatives of ergotamine, auxiliary components of the drug.

 

Application in pregnancy and lactation

 

Nicergoline contraindicated in pregnancy and lactation (breastfeeding).

 

Use in children

 

Contraindicated in children and adolescents under the age of 18 years.

 

Application in elderly patients

 

Older patients with a serum creatinine level greater than 2 mg / dl require a correction of the dosing regimen.

 

special instructions

 

Patients with renal insufficiency and elderly patients with a serum creatinine level greater than 2 mg / dl require a correction of the dosing regimen.

 

After intramuscular or intravenous administration of Nicergoline, the patient should be in a horizontal position for several minutes.

 

With prolonged therapy, patients should be examined at least once every 6 months, with a view to possibly reducing the dose or abolishing Nicergoline.

 

Impact on the ability to drive vehicles and manage mechanisms

 

Despite the fact that Nicergoline helps to improve concentration, the effect of the drug on the ability to drive vehicles and work with mechanisms has not been specifically studied. Given the nature of the underlying disease, patients should be cautious in potentially hazardous activities.

 

Drug Interactions

 

With simultaneous use with antihypertensive drugs, antihypertensive effect is enhanced.

 

With simultaneous application, the effect of indirect anticoagulants and antiaggregants is intensified (possibly an increase in bleeding time).

 

Analogues of the drug Nicergoline

 

Structural analogs for the active substance:

  • Nilogrin;
  • Nicergoline Decaux;
  • Nicergolin Ferein;
  • Sermion.

 

Analogues on the pharmacological group (angioprotectors and microcirculatory correctors):

  • Agapurin;
  • Actovegin;
  • Angiovitis;
  • Antistaks;
  • Arbiflex;
  • Ascorutin;
  • Asnithon;
  • Aescin;
  • Betaver;
  • Betagistin;
  • Betaserc;
  • Bilobil;
  • Bilobil forte;
  • Vazaprostan;
  • Vasoket;
  • Venarus;
  • Venen;
  • Vestibo;
  • Vestap;
  • Ginkgo biloba;
  • Ginkor fort;
  • Detraleks;
  • Diosmin;
  • Dipyridamole;
  • Dicycin;
  • Xantinol nicotinate;
  • Courantil;
  • Memoplant;
  • Methyl ethylpyridinol;
  • A nicotinic acid;
  • Oxygenyl;
  • Pentylin;
  • Pentohexal;
  • Pentoxifylline;
  • Rutin;
  • Solcoseryl;
  • Tagist;
  • Tanakan;
  • Trental;
  • Troxevasin;
  • Troxerutin;
  • Flebodia 600;
  • Phlebofa;
  • Flexitale;
  • Emoxipine;
  • Escuzan;
  • Eszizan;
  • Etamsylate.

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Reviews (14):
Visitors
Lara
Good afternoon! I already sent one message to you here, but I'm not sure if it came to you and whether I sent it right. Therefore I intend to write again, I apologize for the anxiety.
I want to ask you a question about the compatibility of the drug Nicergolin with the drugs Carvedilol, Bisoprolol and Cardiomagnet, with each of them separately, in parallel and sequential (not simultaneous) reception of each of them with Nicergoline. For example: Nicergoline (a-adrenoblocker) and Carvedilol (a and b-adrenoblocker) (a-adrenergic blocking here is superimposed and doubled, which worries me a lot); Nicergoline (a-adrenoblocker) and bisoprolol (b-adrenoblocker); Nicergoline and Cardiomagnet (each of them influences the viscosity of blood in its own way). Is it possible and possible to use them together? Answer me, I beg you very much. I will very much wait for your reply and thank you in advance for him and for your attention. With respect to you.
Administrators
admin
Lara, Nicergoline with Bisoprolol and Cardiomagnum quite combined. Sometimes alpha-blockers and beta-blockers are used together, since mutual potentiation of positive effects on the heart and blood vessels can be observed and this goes into a plus. If before taking one of the drugs,at the beginning of treatment, dynamic monitoring of the patient's condition is necessary in order to evaluate the joint effect and if something goes wrong adjust the dosage of the drugs taken. Also, Nicergoline can be used in conjunction with a Cardiomagnet.
Visitors
Lara
Hello. Thank you very much for your answer. I understand everything about the compatibility of Nicergoline with Bisoprolol and Cardiomagnet, thank you for the clarification. But what about the compatibility of Nicergolin with Carvedilol. They, most likely, are not compatible, yes? Tell me about this, too, please. Thank you again for all. With respect to you.
Administrators
admin
LaraWhy use similar drugs? This is me about the use of Carvedilola and Nicergoline. Nobody assigns such combinations, this oil is oily, because the alpha-blocking effect is present in both of these preparations.
Visitors
Lara
Hello. I again thank you for your early reply.Such responsiveness is very pleasant and valuable! Absolutely agree with you about the compatibility of Nicergolin with Carvedilol, I myself was thinking about the same, having my doubts about the admissibility of such doubling of the alpha-blocking effect. And I wanted to remove these doubts with the help of a specialist to make sure of this from the words of the knowing for sure, and not just how I understand it myself and imagine, therefore I asked you about it. I will say more, I am even worried about myself and frightens the reality of this doubling of the alpha-blocking effect, because it may even be not at all beneficial. Yes, it so happened that the appointment of Nicergolin as a doctor occurred, with the appearance of problems with cerebral circulation, but the doctor at the appointment of it somehow did not even ask what has already been accepted by the patient before. I like it now, it surprises me and even outrages me, but still I want to trust the doctor and trust ... And Carvedilol has already been taken before, because there are problems with the heart and pressure, a whole bouquet ... So, after such an appointment, when I myself have already started to understand everything in everything and check what is there, as they say, I had these doubts.Immediately do this, with the appointment, did not have these necessary knowledge, and now have to find out all this or at least generally communicate with the same doctor there is no way, alas ... So, to take this combination of drugs, I myself have not yet allowed , did not dare, but still, if you need Nicergoline, I'm thinking about taking it with Bisoprolol, which was also accepted before, to Carvedilol, while Carvedilol is still being removed for this time. Although, perhaps taking Carvedilol, which already has the desired alpha-blocking effect, there can be no such need in Nicergolin at all. I already do not even know myself how to do it. What can you say or tell me about all this? Do this, too, I ask you and thank you in advance for everything! Waiting for your reply. With respect and gratitude to you!
Administrators
admin
Lara, Multicomponent schemes you better discuss with the attending physician, because you told well if half of your medical history. I did not see any diagnoses at all. For medicines, advice is given, and clinically you need a lot of input data,to answer correctly. For example, why did they take bisoprolol, then for some reason it was replaced with Carvedilol, now they added Nicergolin. Probably, you also take other medications. We will correspond with the sheets for a month. My rule in the Directory is this - for illnesses, it's for the treating doctors, for medicines - I beg you, I always answer.
Guests
Tatyana
Good afternoon. My daughter is 11 years old. For the treatment of migraine attacks, the doctor prescribed nicergoline. The instructions state that the drug should not be used until age 18. Is it worth giving the medicine to the child?
Administrators
admin
Tatyana, Nicergoline is indeed contraindicated in children and adolescents under 18 years of age, but this is a relative contraindication because this medication does not have a sufficient clinical base for use in this age group of patients. That is, as an experimental, in the absence of analogues, allowed children, it can be used, but migraine is not included in the list of indications for the treatment of which this medication is used.Either the doctor made a mistake with the diagnosis, or the specialist's qualification suffers.
Visitors
lanochka
Good afternoon. I have multiple sclerosis. And every six months in the day hospital I do droppers. Now to me have appointed or nominated nicergolinum 4 mg iv in a dropper and riboksin 10 ml iv, too in the same dropper + 200 ml of saline solution. Today, in carrying out this procedure, I had a severe pain in the vein. Accordingly, I have such a question. Is it possible to combine these 2 drugs in a dropper?

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Administrators
admin
lanochkaPharmacologically, solutions of Nicergoline and Riboxin in a single dropper are combined and additional side effects when used together in the instructions are not indicated. Pain in the vein is caused either by a defect in setting up the dropper itself, or by an individual reaction to the solution as such. It is worth telling about this medical staff, which you put it.
Guests
Galina
Hello! The neurologist prescribed injections in / m of nicergoline ferein and xefokam.Are they compatible? Can I do two injections at the same time?
Administrators
admin
Galina, According to the instruction of negative side effects with the combination of Nicergoline and Xefokam in one therapy scheme should not be. You can stab in one day, but in different buttocks and with different syringes without mixing two solutions in one, because how such a mixture behaves in your body is unknown, it is better not to take chances.
Guests
Olesya
Hello. My dad (age 62 years) takes bisoprolol and lercamen. The doctor prescribed injections of cortexin and nicergoline. Is it possible to combine nicergoline with bisoprolol and lercamen? Will not this be a brute force?
Administrators
admin
OlesyaAll three mentioned in the question of the drug are combined. According to the instruction of negative side effects at their joint reception should not be. Follow the instructions of your father's attending physician.

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