Orlistat - instructions for use, analogs, reviews and release forms (capsules or tablets 120 mg) of the drug for the treatment of obesity, reduce excess weight and weight loss in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Orlistat. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Orlistat in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Orlistat in the presence of existing structural analogues. Use to treat obesity, reduce excess weight and lose weight in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Orlistat inhibitor of lipases.When administered orlistat inhibits gastric and pancreatic lipases. As a result, the breakdown of food fats is violated and their absorption from the digestive tract decreases. With systematic use, this effect leads to a decrease in body weight in patients with obesity. Orlistat is practically not absorbed from the digestive tract and, in connection with this, practically does not have a resorptive effect.

Composition

Orlistat + auxiliary substances.

Pharmacokinetics

In volunteers with normal body weight and obesity, the systemic effect of the drug is minimal. After a single oral intake of the drug at a dose of 360 mg unchanged orlistat in the plasma could not be determined, which means that its concentrations are below 5 ng / ml. Signs of cumulation were absent, which confirms that the absorption of the drug is minimal. In minimal quantities orlistat can penetrate into the erythrocytes. Judging from the data obtained in the experiment on animals, the metabolism of orlistat occurs mainly in the intestinal wall. Studies in individuals with normal and overweight showed that the main way of elimination is to remove the non-sucking drug with feces.With feces about 97% of the dose of the drug was withdrawn, 83% in the form of unchanged orlistat. The total renal excretion of all substances structurally associated with orlistat is less than 2% of the dose taken. Time to complete elimination of the drug from the body (with feces and urine) is 3-5 days.

Indications

• Obesity (combined with a moderate calorie diet).

Forms of release

Capsules 120 mg (sometimes mistakenly called pills).

Instructions for use and reception scheme

Take inside 120 mg at each main meal or within an hour after eating, usually no more than 3 times a day. If the food contains few fats, you can skip the intake of orlistat.

Side effect

• oily discharge from the rectum;
• flatulence;
• the emission of gases with a certain amount of detachable;
• bloating;
• "fat" stool (steatorrhea);
• frequent stool;
• imperative urges for defecation;
• fecal incontinence.

Contraindications

• syndrome of chronic malabsorption;
• cholestasis;
• hypersensitivity to Orlistat.

Application in pregnancy and lactation

With extreme caution use Orlistat during pregnancy and lactation.

In studies of reproductive toxicity in animals, the teratogenic and embryotoxic effect of the drug was not observed. In the absence of a teratogenic effect in animals, one should not expect a similar effect in humans.

Use in children

Not noted.

special instructions

It should be borne in mind that the frequency and severity of side effects increase with an increase in the content of fat in the diet. With a decrease in the fat content of food, the likelihood of side effects decreases. It is recommended that the amount of fat consumed per day is fairly evenly distributed to all meals.

In the process of treatment, as the body weight decreases, it is possible to improve the course of often obesity-related pathological processes, incl. arterial hypertension, diabetes mellitus, violations of lipid metabolism.

Drug Interactions

It is shown that Orlistat leads to a decrease in absorption from the gastrointestinal tract of beta-carotene, alpha-tocopherol.

No interaction with amitriptyline, atorvastatin, biguanides, digoxin, fibrates, fluoxetine, losartan, phenytoin, oral contraceptives, phentermine, pravastatin, warfarin,nifedipine GITS (gastrointestinal therapeutic system) and Nifedipine with slow release, Sibutramine or alcohol (based on studies of interactions between drugs). However, it is necessary to monitor the rates of MNO with concomitant therapy with Warfarin or other oral anticoagulants.

With the simultaneous administration of orlistat and antiepileptic drugs, cases of seizures developed. Causal relationship between the development of seizures and orlistat therapy is not established. However, patients should be monitored for possible changes in the frequency and / or severity of the convulsive syndrome.

Analogues of the drug Orlistat

Structural analogs for the active substance:

• Allie;
• Xenalten;
• Xenalten Light;
• Xenalten Slim;
• Xenical;
• Listat;
• Listata Mini;
• Orlimax;
• Orlimax Light;
• Orlistat the Canon;
• Orsotene;
• Orsoten Slim.

Analogues on the curative effect (means for the treatment of obesity):

• Acnekutan;
• Bacterial balance;
• Carbohydrate blocker;
• Garcilin;
• Garcinia Forte;
• Goldline;
• Diet Comfort;
• Dietol compositum;
• Dietress;
• Dietrin is natural;
• Dr. Theiss Nova figure;
• Ideal;
• Coenzyme Q10 with Ginkgo;
• Lamisplat;
• Lindax;
• Magnesium Complex;
• Meridia;
• Metformin;
• Mukofalk;
• Normoflorin;
• Oxodoline;
• Orsoslim;
• Reduxine;
• Polysorb;
• Sibutramine;
• Slenderness;
• Slenderness Plus;
• Triméks;
• Phenotropil;
• Figurine;
• Phytolax;
• Phytomycyl;
• Hoodia Life;
• Hoodia slim;
• Citrimax Plus Diets formula;
• Citrosept;
• Shugafri.

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