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Arthrosylen - instructions for use, analogs, reviews and release forms (capsules or tablets 320 mg, aerosol or spray, gel or ointment, suppositories, injections for injection) for the treatment of arthrosis in adults, children and pregnancy. Composition

Arthrosylen - instructions for use, analogs, reviews and release forms (capsules or tablets 320 mg, aerosol or spray, gel or ointment, suppositories, injections for injection) for the treatment of arthrosis in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Arthrosilen. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Arthrosilen in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Arthrosilene in the presence of existing structural analogues.Use for the treatment of inflammation and pain in arthritis, arthrosis, articular syndrome in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

 

Arthrosilen - a non-steroidal anti-inflammatory drug (NSAID), a derivative of propionic acid. Has analgesic, anti-inflammatory and antipyretic effect. The mechanism of action is associated with oppression of the activity of COX, the main enzyme of arachidonic acid metabolism, which is the precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever.

 

The pronounced analgesic effect of Ketoprofen (active ingredient of the preparation Arthrosilen) is due to two mechanisms: peripheral (indirectly, through suppression of prostaglandin synthesis) and central (due to the inhibition of the synthesis of prostaglandins in the central and peripheral nervous system, and the effect on the biological activity of other neurotropic substances playing a key role in the release of mediators of pain in the spinal cord). In addition, ketoprofen has anti-bradykinin activity, stabilizes lysosomal membranes,causes significant inhibition of neutrophil activity in patients with rheumatoid arthritis. Suppresses the aggregation of platelets.

 

Composition

 

Ketoprofen lysine (ketoprofen lysine salt) + auxiliary substances.

 

Pharmacokinetics

 

When ingestion and rectal administration, ketoprofen is well absorbed from the digestive tract. Binding to plasma proteins is 99%. Due to pronounced lipophilicity, it rapidly penetrates the blood-brain barrier (BBB). Ketoprofen penetrates well into the synovial fluid, where its concentration 4 hours after intake exceeds that in plasma. Metabolized by binding to glucuronic acid and to a lesser extent by hydroxylation. It is excreted mainly by the kidneys and to a much lesser extent through the intestine.

 

Indications

  • articular syndrome (rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout);
  • symptomatic treatment of inflammatory-degenerative diseases of the musculoskeletal system (periarthritis, arthrosinovitis, tendinitis, tendosinovitis, bursitis, lumbago);
  • pain in the spine;
  • neuralgia;
  • myalgia;
  • uncomplicated injuries, in particular sports, dislocations, sprains or rupture of ligaments and tendons, bruises, post-traumatic pains;
  • in the combination therapy of inflammatory diseases of veins, lymphatic vessels, lymph nodes (phlebitis, periphlebitis, lymphangitis, superficial lymphadenitis).

 

Forms of release

 

Capsules 320 mg (sometimes mistakenly called pills).

 

Aerosol for external use 15% (sometimes mistakenly called a spray).

 

Gel for external use 5% (sometimes mistakenly called ointment or cream).

 

Candles rectal.

 

Solution for intravenous and intramuscular injection (injections in ampoules for injection).

 

Instructions for use and dosage

 

Inside, parenterally, rectally, externally.

 

Capsules

 

Inside, the drug is prescribed 1 capsule per day during or after a meal. Duration of treatment can be 3-4 months.

 

Ampoules

 

Intramuscularly or intravenously, 1 ampoule per day. The maximum daily dose is 1 ampoule 2 times a day. In / in the introduction of the drug is allowed only in the hospital. The drug is used for short treatment - up to 3 days. If it is necessary to continue using the drug, it is recommended to switch to taking oral dosage forms or suppositories. In elderly patients, use no more than 1 ampoule a day.

 

Ampoules should be opened on a special line of the fracture. After opening the ampoule, use the solution immediately.

 

Aqueous solutions of ketoprofen lysine salt can be used in physiotherapeutic treatment (iontophoresis, mesotherapy); with iontophoresis, the solution is applied to the negative pole.

 

When / in the application to increase the duration of the drug is recommended a slow intravenous infusion. Solution for infusion is prepared on the basis of 50 or 500 ml of the following aqueous solutions: 0.9% solution of sodium chloride, 10% aqueous solution of levulose, 5% aqueous solution of dextrose, Ringer's acetate solution, Ringer's solution of lactate (Hartman), colloidal dextran solution in 0 , 9% solution of sodium chloride or 5% solution of dextrose. When Arthrosilen is diluted in small volume solutions (50 ml), the drug is administered iv bolus. In solutions of large volume (500 ml), the infusion duration is at least 30 minutes.

 

Candles

 

Rectally, 1 suppository 2-3 times a day. The maximum daily dose is 480 mg. In elderly patients, no more than 2 suppositories per day should be used.

 

Gel

 

Outwardly. A single dose of the gel is 3-5 g (the volume of a large cherry), aerosol - 1-2 g (the volume of walnut).Depending on the size of the damaged area, the drug should be applied 2-3 times a day or according to the prescriptions of the doctor, gently rubbing until completely absorbed. With iontophoresis, the drug is applied to the negative pole. The duration of treatment without consulting a doctor should not exceed 10 days.

 

Side effect

  • stomach ache;
  • diarrhea;
  • stomatitis, esophagitis;
  • gastritis, duodenitis;
  • erosive and ulcerative lesions of the gastrointestinal tract;
  • hematomesis;
  • melena;
  • increased bilirubin levels;
  • increased activity of hepatic enzymes;
  • hepatitis;
  • liver failure;
  • increased liver size;
  • dizziness;
  • hyperkinesia;
  • tremor;
  • vertigo;
  • mood swings;
  • anxiety;
  • hallucinations;
  • irritability;
  • general malaise;
  • conjunctivitis;
  • impaired vision;
  • hives;
  • angioedema;
  • erythematous exanthema;
  • itching;
  • maculopapular exanthema;
  • increased sweating;
  • multiforme exudative erythema (including Stevens-Johnson syndrome);
  • painful urination;
  • cystitis;
  • edema;
  • hematuria (blood in the urine);
  • violation of the menstrual cycle;
  • leucocytopenia, leukocytosis, lymphangitis, PV reduction, thrombocytopenia, thrombocytopenic purpura;
  • increase in the size of the spleen;
  • vasculitis;
  • bronchospasm;
  • dyspnea;
  • sensation of spasm of the larynx;
  • laryngospasm
  • laryngeal edema;
  • rhinitis;
  • hypertension, hypotension;
  • tachycardia;
  • pain in the chest;
  • peripheral edema;
  • pallor;
  • anaphylactoid reactions;
  • swelling of the oral mucosa;
  • swelling of the pharynx;
  • periorbital edema;
  • burning, itching, heaviness in the anorectal region;
  • exacerbation of hemorrhoids;
  • photosensitization.

 

Contraindications

 

All forms

  • hypersensitivity, incl. to other NSAIDs;
  • aspirin asthma;
  • lactation period;
  • peptic ulcer of the stomach and duodenum in the phase of exacerbation, peptic ulcer;
  • ulcerative colitis in the phase of exacerbation, Crohn's disease;
  • diverticulitis;
  • hemophilia and other disorders of blood clotting;
  • chronic renal failure.

 

Capsules, solution for intravenous and intramuscular injection, rectal suppositories

  • children's age till 15 years.

 

Capsules, suppositories, gel, aerosol

  • pregnancy (3rd trimester).

 

Solution for intravenous and / m administration

  • pregnancy.

 

For external use

  • wetting dermatoses;
  • eczema;
  • violation of the integrity of the skin;
  • children's age till 6 years.

 

Carefully:

  • bronchial asthma;
  • chronic heart failure;
  • elderly age;
  • pregnancy (1, 2 trimester);
  • anemia;
  • alcoholism;
  • tobacco smoking;
  • alcoholic cirrhosis of the liver;
  • hyperbilirubinemia;
  • liver failure;
  • diabetes;
  • dehydration;
  • sepsis;
  • edema;
  • arterial hypertension;
  • blood diseases (including leukopenia);
  • deficiency of glucose-6-phosphate dehydrogenase;
  • stomatitis;
  • hepatic porphyria;
  • erosive and ulcerative lesions of the gastrointestinal tract;
  • severe violations of the liver and kidneys;
  • children under 12 years.

 

Application in pregnancy and lactation

 

Capsules, solution for intravenous and intramuscular injection, rectal suppositories

 

Like other NSAIDs, Arthrosylenum should not be used in the 3rd trimester of pregnancy. Use of the drug in 1 and 2 trimesters should be carefully monitored by the attending physician. Breastfeeding with the use of the drug should be discontinued.

 

Gel, aerosol

 

Can not be used in the 3rd trimester of pregnancy.

 

Experience in the use of arthrosilene during lactation is not available. Use in 1 and 2 trimesters is possible only after consulting a doctor.

 

Use in children

 

Contraindicated at the age of 15 years (for capsules or retard tablets).

 

Outer with caution used in children under 6 years of age.

 

special instructions

 

Capsules, ampoules, rectal suppositories

 

During treatment, it is necessary to monitor the pattern of peripheral blood and the functional state of the liver and kidneys.

 

If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the test.

 

Reception of ketoprofen can mask signs of an infectious disease.

 

If the kidney and liver function is impaired, a dose reduction and careful monitoring is necessary.

 

The use of ketoprofen by patients suffering from bronchial asthma can lead to an attack of bronchial asthma.

 

Women planning a pregnancy should refrain from using the drug, because can reduce the likelihood of implantation of the egg.

 

Gel, aerosol

 

The drug should be applied only to intact skin. Avoid contact with eyes and mucous membranes. To avoid manifestations of hypersensitivity and photosensitivity, it is recommended to avoid exposure to the skin of the sun's rays during the course of treatment.

 

Influence on ability of driving of motor transport and management of mechanisms

 

During the period of drug use, it is necessary to refrain from potentially dangerous activities requiring an increased concentration of attention and speed of psychomotor reactions.

 

Drug Interactions

 

Inducers of microsomal oxidation in the liver (phenytoin, ethanol (alcohol), barbiturates, flumecinol, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites.

 

Reduces the effectiveness of uricosuric drugs, enhances the effect of anticoagulants, antiplatelet agents, fibrinolytics, ethanol, side effects of mineralocorticoids, glucocorticosteroids (GCS), estrogens; hypotensive and diuretics.

 

Joint reception with other NSAIDs, GCS, ethanol (alcohol), corticotropin can lead to the formation of ulcers and the development of gastrointestinal bleeding, an increased risk of kidney dysfunction.

 

Simultaneous administration with oral anticoagulants, heparin, thrombolytic agents, antiaggregants, cefoperazone, cefamandol and cefotetan increases the risk of bleeding.

 

Increases hypoglycemic action of insulin and oral hypoglycemic drugs (dose recalculation is necessary).

 

Co-administration with sodium valproate causes disruption of platelet aggregation.

 

Increases the concentration in the plasma of Verapamil and nifedipine, lithium, methotrexate.

 

Antacids and colestyramine reduce absorption.

 

Analogues of the drug Arthrosilen

 

Structural analogs for the active substance:

  • Arketal Rompharm;
  • Artrum;
  • Bystrumgel;
  • Bystrumcaps;
  • Valusal;
  • Ketonal;
  • Ketonal Uno;
  • Ketonal Duo;
  • Ketoprofen;
  • Ketosphere;
  • OCI;
  • Oruvel;
  • Profenide;
  • Fastum;
  • Fastum gel;
  • Febrofide;
  • Flamax;
  • Flamax forte;
  • Fleksen.

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