Tolperisone - instructions for use, analogs, reviews and release forms (tablets 50 mg and 150 mg, OBL, injections in ampoules for injections with lidocaine Richter) drug for the treatment of epilepsy, seizures in adults, children and pregnancy

In this article, you can read the instructions for using the drug Tolmoreyson. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Tolperisone in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Tolperison in the presence of existing structural analogues.Use for the treatment of epilepsy, seizures, spasms, parkinsonism in adults, children, as well as during pregnancy and lactation.

Tolmoreyson - Muscle relaxant of central action. Reduction of the pathologically increased tone of skeletal muscles is explained by the ability of tolperisone to suppress spinal polysynaptic reflexes and inhibitory effect on the caudal part of the reticular formation. Has central n-anticholinergic properties. Does not have a significant effect on the peripheral parts of the nervous system. Has a weak spasmolytic and vasodilating effect.

Composition

Tolperisone hydrochloride + auxiliary substances.

Pharmacokinetics

It is subject to intensive metabolism in the liver and kidneys. It is excreted by the kidneys, almost exclusively (more than 99%) in the form of metabolites whose pharmacological activity is unknown.

Indications

• spinal and cerebral palsy (hypertonus, muscle spasm, spinal automatism, limb contracture);
• diseases accompanied by dystonia, stiffness, muscle spasm; obliterating arterial diseases: obliterating atherosclerosis of the vessels of the extremities, diabetic angiopathy, obliterating thromboangiitis (Buerger's disease), Raynaud's syndrome;
• consequences of disorders of vascular innervation (acrocyanosis, intermittent angioedema dysbasia);
• extrapyramidal disorders (postencephalitic and atherosclerotic parkinsonism);
• post-thrombotic disorders of lymph circulation and venous circulation, trophic ulceration of the lower leg, infantile spastic paralysis (Little's disease), epilepsy, encephalopathy of vascular genesis; Hypertension in combination with a violation of muscle tone of another type.

Forms of release

Tablets coated with 50 mg and 150 mg.

Solution for injection with Lidocaine (Midokalm Richter) (injections in ampoules).

Instructions for use and dosing regimen

Pills

When administered orally, the initial dose is 50 mg 2-3 times a day; The dose is gradually increased to 150 mg 2-3 times a day.

Ampoules

Intramuscular - 100 mg twice a day; intravenously - 100 mg per day once.

Side effect

• headache;
• myasthenia gravis;
• arterial hypotension;
• nausea, vomiting;
• gastralgia;
• allergic reactions (anaphylactic shock, bronchospasm, urticaria, erythematous rashes, skin itching).

Contraindications

• myasthenia gravis;
• pregnancy;
• lactation period;
• children and adolescents under 18;
• hypersensitivity to tolperisone.

Application in pregnancy and lactation

Tolperisone is contraindicated in pregnancy, during lactation.

Use in children

Contraindicated in children and adolescents under the age of 18 years.

special instructions

Use with caution in patients with renal and hepatic insufficiency. Correction of the dose is not required.

Impact on the ability to drive vehicles and manage mechanisms

Use with caution in patients whose activities require increased attention and speed of psychomotor reactions.

Drug Interactions

The action of tolperisone is enhanced when used simultaneously with drugs for general anesthesia, peripheral muscle relaxants, psychoactive drugs, and clonidine.

Does not increase the effect of ethanol (alcohol) on the central nervous system.

Increases the effect of non-steroidal anti-inflammatory drugs (NSAIDs), so with a simultaneous appointment, you may need to reduce their dose.

Analogues of the drug Tolperizone

Structural analogs for the active substance:

• Midokalm;
• Midokalm Richter;
• Tolizor;
• Tolperisone OBL;
• Tolperisone hydrochloride.

Analogues on the pharmacological group (n-anticholinergics, muscle relaxants):

• Aperomide;
• Arduan;
• Dithilin;
• Croaron;
• Listenon;
• Mivacron;
• Midokalm;
• Nimbex;
• Notrixum;
• Pipecuronium bromide;
• Rokuroniy Kaby;
• Suxamethonium chloride;
• Terkuronia injection for 0.5%;
• Trakrium;
• Tubokurarin;
• Cisatracurium bezylate;
• Esmeron.

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